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Marine-Lenhart syndrome in two adolescents, including one with thyroid cancer: a case series and review of the literature.
J Pediatr Endocrinol Metab. 2017 Nov 27; 30(12):1237-1243.JP

Abstract

BACKGROUND

The coexistence of functional thyroid nodules and Graves' disease (GD) is a rare condition known as Marine-Lenhart syndrome. Thyroid cancer has been described in several adults, but never in children, with Marine-Lenhart syndrome. This paper discusses the challenges in diagnosis and the unique management of this condition in children, in the context of extant literature.

CONTENT

In this case report, two adolescent female patients with Marine-Lenhart syndrome, aged 15 and 16 years, exhibited biochemical evidence of hyperthyroidism, and were found to have unilateral hyperfunctioning thyroid nodules via thyroid scintigraphy. Additionally, both patients showed elevated thyroid-stimulating immunoglobulins (TSI) and increased glandular activity, confirming background GD. Notably, one patient was also diagnosed with intranodular thyroid cancer upon preoperative examination. Both patients were treated via surgical resection. Summary and outlook: Diagnosis of Marine-Lenhart syndrome can be made in patients with functional thyroid nodules and increased glandular activity on thyroid scintigraphy. Standard doses of radioiodine ablation are not effective in the majority of patients and should be avoided due to the increased risk for thyroid cancer, making thyroidectomy the preferred treatment.

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

29127767

Citation

Sharma, Animesh. "Marine-Lenhart Syndrome in Two Adolescents, Including One With Thyroid Cancer: a Case Series and Review of the Literature." Journal of Pediatric Endocrinology & Metabolism : JPEM, vol. 30, no. 12, 2017, pp. 1237-1243.
Sharma A. Marine-Lenhart syndrome in two adolescents, including one with thyroid cancer: a case series and review of the literature. J Pediatr Endocrinol Metab. 2017;30(12):1237-1243.
Sharma, A. (2017). Marine-Lenhart syndrome in two adolescents, including one with thyroid cancer: a case series and review of the literature. Journal of Pediatric Endocrinology & Metabolism : JPEM, 30(12), 1237-1243. https://doi.org/10.1515/jpem-2017-0223
Sharma A. Marine-Lenhart Syndrome in Two Adolescents, Including One With Thyroid Cancer: a Case Series and Review of the Literature. J Pediatr Endocrinol Metab. 2017 Nov 27;30(12):1237-1243. PubMed PMID: 29127767.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Marine-Lenhart syndrome in two adolescents, including one with thyroid cancer: a case series and review of the literature. A1 - Sharma,Animesh, PY - 2017/06/02/received PY - 2017/10/09/accepted PY - 2017/11/12/pubmed PY - 2018/7/31/medline PY - 2017/11/12/entrez KW - Graves’ disease (GD) KW - Marine-Lenhart syndrome KW - children and adolescents KW - hot nodule KW - thyroid cancer SP - 1237 EP - 1243 JF - Journal of pediatric endocrinology & metabolism : JPEM JO - J. Pediatr. Endocrinol. Metab. VL - 30 IS - 12 N2 - BACKGROUND: The coexistence of functional thyroid nodules and Graves' disease (GD) is a rare condition known as Marine-Lenhart syndrome. Thyroid cancer has been described in several adults, but never in children, with Marine-Lenhart syndrome. This paper discusses the challenges in diagnosis and the unique management of this condition in children, in the context of extant literature. CONTENT: In this case report, two adolescent female patients with Marine-Lenhart syndrome, aged 15 and 16 years, exhibited biochemical evidence of hyperthyroidism, and were found to have unilateral hyperfunctioning thyroid nodules via thyroid scintigraphy. Additionally, both patients showed elevated thyroid-stimulating immunoglobulins (TSI) and increased glandular activity, confirming background GD. Notably, one patient was also diagnosed with intranodular thyroid cancer upon preoperative examination. Both patients were treated via surgical resection. Summary and outlook: Diagnosis of Marine-Lenhart syndrome can be made in patients with functional thyroid nodules and increased glandular activity on thyroid scintigraphy. Standard doses of radioiodine ablation are not effective in the majority of patients and should be avoided due to the increased risk for thyroid cancer, making thyroidectomy the preferred treatment. SN - 2191-0251 UR - https://www.unboundmedicine.com/medline/citation/29127767/Marine_Lenhart_syndrome_in_two_adolescents_including_one_with_thyroid_cancer:_a_case_series_and_review_of_the_literature_ L2 - https://www.degruyter.com/doi/10.1515/jpem-2017-0223 DB - PRIME DP - Unbound Medicine ER -