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Low influenza vaccine effectiveness and the effect of previous vaccination in preventing admission with A(H1N1)pdm09 or B/Victoria-Lineage in patients 60 years old or older during the 2015/2016 influenza season.
Vaccine. 2017 12 19; 35(52):7331-7338.V

Abstract

BACKGROUND

The 2015/2016 influenza season was characterized in Europe by the circulation of A(H1N1)pdm09 clade 6B.1 and B/Victoria-lineage influenza viruses. The components of the vaccines used in the current and past two seasons in the Valencia region were similar but not well matched to the 2015/2016 dominant influenza-circulating strains. We estimate influenza vaccine effectiveness (IVE) and interference of previous vaccination in preventing admission with A(H1N1)pdm09 or B/Victoria-lineage in this particular season.

METHODS

The Valencia Hospital Network for the Study of Influenza runs an active surveillance hospital-based study to collect clinical and virological data from consecutive admissions possibly related to influenza. Combined nasopharyngeal and pharyngeal swabs are analyzed by reverse transcription polymerase chain reaction, and the hemagglutinin is sequenced in a sample of positive influenza specimens. Vaccination is ascertained consulting a population vaccine information system. We estimate IVE using a test-negative approach.

RESULTS

During the 2015-2016 season, we recruited 1049 eligible admissions of patients 60 years or older, and 187 tested positive for influenza. The adjusted IVE in preventing admission with A(H1N1)pdm09 was 20.2%; 95% confidence interval (CI) -21.3-47.5% and -33.2%; 95% CI, -140.1-26.1% in preventing admission with B/Victoria-lineage. The majority of A(H1N1)pdm09 sequenced viruses belonged to the emerging 6B.1 subclade, defined by S162N and I216T mutations in the hemagglutinin protein. When we restricted our analysis to those not vaccinated in the previous year, unadjusted IVE was 84.9% (95% CI 9.9-100.0) overall, 77.9% (-32.7-100.0%) in preventing A(H1N1)pdm09 and 48.8% (-219.5-100.0%) in preventing B/Yamagata-lineage admission.

CONCLUSIONS

Our findings indicate that IVE was low in preventing A(H1N1)pdm09 and strongly correlated with vaccination in the previous season. No effect in preventing admission with B/Victoria-lineage was observed. For the 2015/2016 season, IVE was low due to a mismatch and lack of concordance between the circulating and vaccine viruses.

Authors+Show Affiliations

Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Valencia, Spain; Centro de Salud Pública de Castellón, Castellón, Spain. Electronic address: puig_joa@gva.es.Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Valencia, Spain.Hospital Doctor Peset, Valencia, Spain.Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Valencia, Spain; Consorcio de Investigación Biomédica de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.Hospital General Universitario de Castellón, Universidad CEU-UCH Castellón, Spain.Hospital Universitario y Politécnico La Fe, Valencia, Spain.Hospital General de Alicante, Alicante, Spain.Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Valencia, Spain.Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Valencia, Spain.Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Valencia, Spain.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29128380

Citation

Puig-Barberà, Joan, et al. "Low Influenza Vaccine Effectiveness and the Effect of Previous Vaccination in Preventing Admission With A(H1N1)pdm09 or B/Victoria-Lineage in Patients 60 Years Old or Older During the 2015/2016 Influenza Season." Vaccine, vol. 35, no. 52, 2017, pp. 7331-7338.
Puig-Barberà J, Guglieri-López B, Tortajada-Girbés M, et al. Low influenza vaccine effectiveness and the effect of previous vaccination in preventing admission with A(H1N1)pdm09 or B/Victoria-Lineage in patients 60 years old or older during the 2015/2016 influenza season. Vaccine. 2017;35(52):7331-7338.
Puig-Barberà, J., Guglieri-López, B., Tortajada-Girbés, M., López-Labrador, F. X., Carballido-Fernández, M., Mollar-Maseres, J., Schwarz-Chavarri, G., Baselga-Moreno, V., Mira-Iglesias, A., & Díez-Domingo, J. (2017). Low influenza vaccine effectiveness and the effect of previous vaccination in preventing admission with A(H1N1)pdm09 or B/Victoria-Lineage in patients 60 years old or older during the 2015/2016 influenza season. Vaccine, 35(52), 7331-7338. https://doi.org/10.1016/j.vaccine.2017.10.100
Puig-Barberà J, et al. Low Influenza Vaccine Effectiveness and the Effect of Previous Vaccination in Preventing Admission With A(H1N1)pdm09 or B/Victoria-Lineage in Patients 60 Years Old or Older During the 2015/2016 Influenza Season. Vaccine. 2017 12 19;35(52):7331-7338. PubMed PMID: 29128380.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low influenza vaccine effectiveness and the effect of previous vaccination in preventing admission with A(H1N1)pdm09 or B/Victoria-Lineage in patients 60 years old or older during the 2015/2016 influenza season. AU - Puig-Barberà,Joan, AU - Guglieri-López,Beatriz, AU - Tortajada-Girbés,Miguel, AU - López-Labrador,F Xavier, AU - Carballido-Fernández,Mario, AU - Mollar-Maseres,Joan, AU - Schwarz-Chavarri,Germán, AU - Baselga-Moreno,Víctor, AU - Mira-Iglesias,Ainara, AU - Díez-Domingo,Javier, AU - ,, Y1 - 2017/11/08/ PY - 2017/04/19/received PY - 2017/09/15/revised PY - 2017/10/31/accepted PY - 2017/11/13/pubmed PY - 2018/8/1/medline PY - 2017/11/13/entrez KW - Epidemiology KW - Influenza virus KW - Surveillance KW - Vaccine SP - 7331 EP - 7338 JF - Vaccine JO - Vaccine VL - 35 IS - 52 N2 - BACKGROUND: The 2015/2016 influenza season was characterized in Europe by the circulation of A(H1N1)pdm09 clade 6B.1 and B/Victoria-lineage influenza viruses. The components of the vaccines used in the current and past two seasons in the Valencia region were similar but not well matched to the 2015/2016 dominant influenza-circulating strains. We estimate influenza vaccine effectiveness (IVE) and interference of previous vaccination in preventing admission with A(H1N1)pdm09 or B/Victoria-lineage in this particular season. METHODS: The Valencia Hospital Network for the Study of Influenza runs an active surveillance hospital-based study to collect clinical and virological data from consecutive admissions possibly related to influenza. Combined nasopharyngeal and pharyngeal swabs are analyzed by reverse transcription polymerase chain reaction, and the hemagglutinin is sequenced in a sample of positive influenza specimens. Vaccination is ascertained consulting a population vaccine information system. We estimate IVE using a test-negative approach. RESULTS: During the 2015-2016 season, we recruited 1049 eligible admissions of patients 60 years or older, and 187 tested positive for influenza. The adjusted IVE in preventing admission with A(H1N1)pdm09 was 20.2%; 95% confidence interval (CI) -21.3-47.5% and -33.2%; 95% CI, -140.1-26.1% in preventing admission with B/Victoria-lineage. The majority of A(H1N1)pdm09 sequenced viruses belonged to the emerging 6B.1 subclade, defined by S162N and I216T mutations in the hemagglutinin protein. When we restricted our analysis to those not vaccinated in the previous year, unadjusted IVE was 84.9% (95% CI 9.9-100.0) overall, 77.9% (-32.7-100.0%) in preventing A(H1N1)pdm09 and 48.8% (-219.5-100.0%) in preventing B/Yamagata-lineage admission. CONCLUSIONS: Our findings indicate that IVE was low in preventing A(H1N1)pdm09 and strongly correlated with vaccination in the previous season. No effect in preventing admission with B/Victoria-lineage was observed. For the 2015/2016 season, IVE was low due to a mismatch and lack of concordance between the circulating and vaccine viruses. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/29128380/Low_influenza_vaccine_effectiveness_and_the_effect_of_previous_vaccination_in_preventing_admission_with_A_H1N1_pdm09_or_B/Victoria_Lineage_in_patients_60_years_old_or_older_during_the_2015/2016_influenza_season_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(17)31529-3 DB - PRIME DP - Unbound Medicine ER -