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Early impact of rotavirus vaccination in children less than five years of age in Mozambique.
Vaccine. 2018 11 12; 36(47):7205-7209.V

Abstract

BACKGROUND

Mozambique introduced rotavirus vaccine (Rotarix, GSK Biologicals) in the National Immunization Program in September 2015 with the objective of reducing the burden of total diarrheal disease and specifically severe rotavirus disease. This study aimed to evaluate the early impact of rotavirus vaccine in reducing all-cause diarrhea and rotavirus-specific hospitalizations.

METHODS

We analysed stool specimens collected from children under five years old, between January 2014 and June 2017 within the National Surveillance for Acute Diarrhea. We compared annual changes in rotavirus positivity, median age of children hospitalized for rotavirus and the number of all-cause for diarrheal hospitalizations. Rotavirus detection was performed using enzyme immunoassay.

RESULTS

During this period, 1296 samples were collected and analyzed. Rotavirus positivity before vaccine introduction was 40.2% (39/97) in 2014 and 38.3% (225/588) in 2015, then after vaccine introduction reduced to 12.2% and 13.5% in 2016 and 2017, respectively. The median age of children hospitalized for rotavirus was 9 and 11 months in 2014 and 2015 and 10 months in 2016 and 2017. Rotavirus hospitalizations exhibited a seasonal peak prior to vaccine introduction, between June and September in 2014 and 2015, coinciding with winter period in Mozambique. After vaccine introduction, the peak was delayed until August to December in 2016 and was substantially diminished. There was a reduction in all-cause acute diarrhea hospitalizations in children aged 0-11 months after vaccine introduction.

CONCLUSION

We observed a reduction in rotavirus positivity and in the number of all-cause diarrhea hospitalizations after vaccine introduction. The data suggest rotavirus vaccine is having a positive impact on the control of rotavirus diarrheal disease in Mozambique.

Authors+Show Affiliations

Instituto Nacional de Saúde, Ministério da Saúde, Maputo, Mozambique. Electronic address: ndeus1@yahoo.com.Instituto Nacional de Saúde, Ministério da Saúde, Maputo, Mozambique.Instituto Nacional de Saúde, Ministério da Saúde, Maputo, Mozambique.Instituto Nacional de Saúde, Ministério da Saúde, Maputo, Mozambique.Instituto Nacional de Saúde, Ministério da Saúde, Maputo, Mozambique.Hospital Central de Nampula, Ministério da Saúde, Nampula, Mozambique.Faculdade de Ciências, Universidade Eduardo Mondlane, Mozambique.Instituto Nacional de Saúde, Ministério da Saúde, Maputo, Mozambique.Instituto Nacional de Saúde, Ministério da Saúde, Maputo, Mozambique.Instituto Nacional de Saúde, Ministério da Saúde, Maputo, Mozambique.Instituto Nacional de Saúde, Ministério da Saúde, Maputo, Mozambique.Instituto Nacional de Saúde, Ministério da Saúde, Maputo, Mozambique; Institute of Hygiene and Tropical Medicine, New University of Lisbon, Lisbon, Portugal.Instituto Nacional de Saúde, Ministério da Saúde, Maputo, Mozambique.World Health Organization (WHO), Regional Office for Africa, Brazzaville, People's Republic of Congo.Intercountry Support Team (IST), World Health Organization (WHO), Harare, Zimbabwe.Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

29128381

Citation

de Deus, Nilsa, et al. "Early Impact of Rotavirus Vaccination in Children Less Than Five Years of Age in Mozambique." Vaccine, vol. 36, no. 47, 2018, pp. 7205-7209.
de Deus N, Chilaúle JJ, Cassocera M, et al. Early impact of rotavirus vaccination in children less than five years of age in Mozambique. Vaccine. 2018;36(47):7205-7209.
de Deus, N., Chilaúle, J. J., Cassocera, M., Bambo, M., Langa, J. S., Sitoe, E., Chissaque, A., Anapakala, E., Sambo, J., Guimarães, E. L., Bero, D. M., João, E. D., Cossa-Moiane, I., Mwenda, J. M., Weldegebriel, G. G., Parashar, U. D., & Tate, J. E. (2018). Early impact of rotavirus vaccination in children less than five years of age in Mozambique. Vaccine, 36(47), 7205-7209. https://doi.org/10.1016/j.vaccine.2017.10.060
de Deus N, et al. Early Impact of Rotavirus Vaccination in Children Less Than Five Years of Age in Mozambique. Vaccine. 2018 11 12;36(47):7205-7209. PubMed PMID: 29128381.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early impact of rotavirus vaccination in children less than five years of age in Mozambique. AU - de Deus,Nilsa, AU - Chilaúle,Jorfélia José, AU - Cassocera,Marta, AU - Bambo,Miguel, AU - Langa,Jerónimo Sozinho, AU - Sitoe,Ezequias, AU - Chissaque,Assucênio, AU - Anapakala,Elda, AU - Sambo,Júlia, AU - Guimarães,Esperança Lourenço, AU - Bero,Diocreciano Matias, AU - João,Eva Dora, AU - Cossa-Moiane,Idalécia, AU - Mwenda,Jason M, AU - Weldegebriel,Goitom G, AU - Parashar,Umesh D, AU - Tate,Jacqueline E, Y1 - 2017/11/08/ PY - 2017/05/28/received PY - 2017/09/04/revised PY - 2017/10/17/accepted PY - 2017/11/13/pubmed PY - 2019/2/15/medline PY - 2017/11/13/entrez KW - Acute diarrhea disease KW - Children KW - Impact vaccine KW - Rotavirus vaccine SP - 7205 EP - 7209 JF - Vaccine JO - Vaccine VL - 36 IS - 47 N2 - BACKGROUND: Mozambique introduced rotavirus vaccine (Rotarix, GSK Biologicals) in the National Immunization Program in September 2015 with the objective of reducing the burden of total diarrheal disease and specifically severe rotavirus disease. This study aimed to evaluate the early impact of rotavirus vaccine in reducing all-cause diarrhea and rotavirus-specific hospitalizations. METHODS: We analysed stool specimens collected from children under five years old, between January 2014 and June 2017 within the National Surveillance for Acute Diarrhea. We compared annual changes in rotavirus positivity, median age of children hospitalized for rotavirus and the number of all-cause for diarrheal hospitalizations. Rotavirus detection was performed using enzyme immunoassay. RESULTS: During this period, 1296 samples were collected and analyzed. Rotavirus positivity before vaccine introduction was 40.2% (39/97) in 2014 and 38.3% (225/588) in 2015, then after vaccine introduction reduced to 12.2% and 13.5% in 2016 and 2017, respectively. The median age of children hospitalized for rotavirus was 9 and 11 months in 2014 and 2015 and 10 months in 2016 and 2017. Rotavirus hospitalizations exhibited a seasonal peak prior to vaccine introduction, between June and September in 2014 and 2015, coinciding with winter period in Mozambique. After vaccine introduction, the peak was delayed until August to December in 2016 and was substantially diminished. There was a reduction in all-cause acute diarrhea hospitalizations in children aged 0-11 months after vaccine introduction. CONCLUSION: We observed a reduction in rotavirus positivity and in the number of all-cause diarrhea hospitalizations after vaccine introduction. The data suggest rotavirus vaccine is having a positive impact on the control of rotavirus diarrheal disease in Mozambique. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/29128381/Early_impact_of_rotavirus_vaccination_in_children_less_than_five_years_of_age_in_Mozambique_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(17)31468-8 DB - PRIME DP - Unbound Medicine ER -