Tags

Type your tag names separated by a space and hit enter

Resection of melanocytic nevi as a potential treatment of anti-NMDAR encephalitis patients without tumor: report of three cases.
Neurol Sci. 2018 Jan; 39(1):165-167.NS

Abstract

The most common underlying tumor associated with anti-N-methyl D-aspartate-receptor (NMDAR) encephalitis is ovarian teratoma. Resection of the underlying tumor may decrease exposure of autoantigen and make for faster response of immunotherapy and less relapse frequency. Similar to teratoma, expression of NMDAR in human epidermal melanocytes was suspected recently. The dense melanocytes in melanocytic nevus may serve as potential autoantigens and are prone to increase relapse frequency in the tumor-negative patients. Three patients with confirmed diagnosis of anti-NMDAR encephalitis were described here. They shared common features that the screening tests for an ovarian teratoma or other tumors were all negative, while they were found to have prominent melanocytic nevi on the skin and resection of the nevi likely played a positive effect on their persistent recovery. This is a report on treatment of anti-NMDAR encephalitis patients without underlying tumor through resection of melanocytic nevi. More clinical and experimental investigations are needed to prove its validity.

Authors+Show Affiliations

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China. qutao2011@126.com.Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China. guanhz@263.net.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

29128985

Citation

Yin, Hexiang, et al. "Resection of Melanocytic Nevi as a Potential Treatment of anti-NMDAR Encephalitis Patients Without Tumor: Report of Three Cases." Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 39, no. 1, 2018, pp. 165-167.
Yin H, Zhu C, Ren H, et al. Resection of melanocytic nevi as a potential treatment of anti-NMDAR encephalitis patients without tumor: report of three cases. Neurol Sci. 2018;39(1):165-167.
Yin, H., Zhu, C., Ren, H., Yang, X., Peng, B., Cui, L., Qu, T., & Guan, H. (2018). Resection of melanocytic nevi as a potential treatment of anti-NMDAR encephalitis patients without tumor: report of three cases. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 39(1), 165-167. https://doi.org/10.1007/s10072-017-3173-5
Yin H, et al. Resection of Melanocytic Nevi as a Potential Treatment of anti-NMDAR Encephalitis Patients Without Tumor: Report of Three Cases. Neurol Sci. 2018;39(1):165-167. PubMed PMID: 29128985.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Resection of melanocytic nevi as a potential treatment of anti-NMDAR encephalitis patients without tumor: report of three cases. AU - Yin,Hexiang, AU - Zhu,Chenyu, AU - Ren,Haitao, AU - Yang,Xunzhe, AU - Peng,Bin, AU - Cui,Liying, AU - Qu,Tao, AU - Guan,Hongzhi, Y1 - 2017/11/11/ PY - 2017/07/28/received PY - 2017/10/25/accepted PY - 2017/11/13/pubmed PY - 2018/8/16/medline PY - 2017/11/13/entrez KW - Anti-NMDAR encephalitis KW - Autoantigen KW - Melanocyte KW - Treatment KW - Tumor-negative SP - 165 EP - 167 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol. Sci. VL - 39 IS - 1 N2 - The most common underlying tumor associated with anti-N-methyl D-aspartate-receptor (NMDAR) encephalitis is ovarian teratoma. Resection of the underlying tumor may decrease exposure of autoantigen and make for faster response of immunotherapy and less relapse frequency. Similar to teratoma, expression of NMDAR in human epidermal melanocytes was suspected recently. The dense melanocytes in melanocytic nevus may serve as potential autoantigens and are prone to increase relapse frequency in the tumor-negative patients. Three patients with confirmed diagnosis of anti-NMDAR encephalitis were described here. They shared common features that the screening tests for an ovarian teratoma or other tumors were all negative, while they were found to have prominent melanocytic nevi on the skin and resection of the nevi likely played a positive effect on their persistent recovery. This is a report on treatment of anti-NMDAR encephalitis patients without underlying tumor through resection of melanocytic nevi. More clinical and experimental investigations are needed to prove its validity. SN - 1590-3478 UR - https://www.unboundmedicine.com/medline/citation/29128985/Resection_of_melanocytic_nevi_as_a_potential_treatment_of_anti_NMDAR_encephalitis_patients_without_tumor:_report_of_three_cases_ L2 - https://dx.doi.org/10.1007/s10072-017-3173-5 DB - PRIME DP - Unbound Medicine ER -