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Availability and approval of cannabis-based medicines for chronic pain management and palliative/supportive care in Europe: A survey of the status in the chapters of the European Pain Federation.

Abstract

BACKGROUND

There is considerable public and political interest in the use of cannabis products for medical purposes.

METHODS

The task force of the European Pain Federation (EFIC) conducted a survey with its national chapters representatives on the status of approval of all types of cannabis-based medicines, the covering of costs and the availability of a position paper of a national medical association on the use of medical cannabis for chronic pain and for symptom control in palliative/supportive care.

RESULTS

Thirty-one out of 37 contacted councillors responded. Plant-derived tetrahydrocannabinol/cannabidiol (THC/CBD) oromucosal spray is approved for spasticity in multiple sclerosis refractory to conventional treatment in 21 EFIC chapters. Plant-derived THC (dronabinol) is approved for some palliative care conditions in four EFIC chapters. Synthetic THC analogue (nabilone) is approved for chemotherapy-associated nausea and vomiting refractory to conventional treatment in four EFIC chapters'. Eight EFIC chapters' countries have an exceptional and six chapters an expanded access programme for medical cannabis. German and Israeli pain societies recommend the use of cannabis-based medicines as third-line drug therapies for chronic pain within a multicomponent approach. Conversely, the German medical association and a team of finish experts and officials do not recommend the prescription of medical cannabis due to the lack of high-quality evidence of efficacy and the potential harms.

CONCLUSIONS

There are marked differences between the countries represented in EFIC in the approval and availability of cannabis-based products for medical use. EFIC countries are encouraged to collaborate with the European Medicines Agency to publish a common document on cannabis-based medicines.

SIGNIFICANCE

There are striking differences between European countries in the availability of plant-derived and synthetic cannabinoids and of medical cannabis for pain management and for symptom control in palliative care and in the covering of costs by health insurance companies or state social security systems.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Anesthesiology, Intensive Care and Pain Treatment, University Medical Center Maribor, Slovenia. Faculty of Medicine of University Maribor, Institute for Palliative Medicine and Care, Slovenia.

    ,

    Pain Medicine, Pain Matters Ltd, Liverpool, UK.

    Department Internal Medicine 1, Klinikum Saarbrücken gGmbH, Germany. Department Psychosomatic Medicine and Psychotherapy, Technische Universität München, Germany.

    Source

    MeSH

    Antiemetics
    Antineoplastic Agents
    Cannabidiol
    Cannabinoid Receptor Agonists
    Chronic Pain
    Dronabinol
    Drug Approval
    Drug Combinations
    Europe
    Germany
    Humans
    Israel
    Medical Marijuana
    Multiple Sclerosis
    Muscle Spasticity
    Nausea
    Pain Management
    Palliative Care
    Societies, Medical
    Surveys and Questionnaires
    Vomiting

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    29134767

    Citation

    Krcevski-Skvarc, N, et al. "Availability and Approval of Cannabis-based Medicines for Chronic Pain Management and Palliative/supportive Care in Europe: a Survey of the Status in the Chapters of the European Pain Federation." European Journal of Pain (London, England), vol. 22, no. 3, 2018, pp. 440-454.
    Krcevski-Skvarc N, Wells C, Häuser W. Availability and approval of cannabis-based medicines for chronic pain management and palliative/supportive care in Europe: A survey of the status in the chapters of the European Pain Federation. Eur J Pain. 2018;22(3):440-454.
    Krcevski-Skvarc, N., Wells, C., & Häuser, W. (2018). Availability and approval of cannabis-based medicines for chronic pain management and palliative/supportive care in Europe: A survey of the status in the chapters of the European Pain Federation. European Journal of Pain (London, England), 22(3), pp. 440-454. doi:10.1002/ejp.1147.
    Krcevski-Skvarc N, Wells C, Häuser W. Availability and Approval of Cannabis-based Medicines for Chronic Pain Management and Palliative/supportive Care in Europe: a Survey of the Status in the Chapters of the European Pain Federation. Eur J Pain. 2018;22(3):440-454. PubMed PMID: 29134767.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Availability and approval of cannabis-based medicines for chronic pain management and palliative/supportive care in Europe: A survey of the status in the chapters of the European Pain Federation. AU - Krcevski-Skvarc,N, AU - Wells,C, AU - Häuser,W, Y1 - 2017/11/13/ PY - 2017/10/10/accepted PY - 2017/11/15/pubmed PY - 2019/1/8/medline PY - 2017/11/15/entrez SP - 440 EP - 454 JF - European journal of pain (London, England) JO - Eur J Pain VL - 22 IS - 3 N2 - BACKGROUND: There is considerable public and political interest in the use of cannabis products for medical purposes. METHODS: The task force of the European Pain Federation (EFIC) conducted a survey with its national chapters representatives on the status of approval of all types of cannabis-based medicines, the covering of costs and the availability of a position paper of a national medical association on the use of medical cannabis for chronic pain and for symptom control in palliative/supportive care. RESULTS: Thirty-one out of 37 contacted councillors responded. Plant-derived tetrahydrocannabinol/cannabidiol (THC/CBD) oromucosal spray is approved for spasticity in multiple sclerosis refractory to conventional treatment in 21 EFIC chapters. Plant-derived THC (dronabinol) is approved for some palliative care conditions in four EFIC chapters. Synthetic THC analogue (nabilone) is approved for chemotherapy-associated nausea and vomiting refractory to conventional treatment in four EFIC chapters'. Eight EFIC chapters' countries have an exceptional and six chapters an expanded access programme for medical cannabis. German and Israeli pain societies recommend the use of cannabis-based medicines as third-line drug therapies for chronic pain within a multicomponent approach. Conversely, the German medical association and a team of finish experts and officials do not recommend the prescription of medical cannabis due to the lack of high-quality evidence of efficacy and the potential harms. CONCLUSIONS: There are marked differences between the countries represented in EFIC in the approval and availability of cannabis-based products for medical use. EFIC countries are encouraged to collaborate with the European Medicines Agency to publish a common document on cannabis-based medicines. SIGNIFICANCE: There are striking differences between European countries in the availability of plant-derived and synthetic cannabinoids and of medical cannabis for pain management and for symptom control in palliative care and in the covering of costs by health insurance companies or state social security systems. SN - 1532-2149 UR - https://www.unboundmedicine.com/medline/citation/29134767/Availability_and_approval_of_cannabis_based_medicines_for_chronic_pain_management_and_palliative/supportive_care_in_Europe:_A_survey_of_the_status_in_the_chapters_of_the_European_Pain_Federation_ L2 - https://doi.org/10.1002/ejp.1147 DB - PRIME DP - Unbound Medicine ER -