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Cow's milk whey protein elicits symptoms of infantile colic in colicky formula-fed infants: a double-blind crossover study.
Pediatrics 1989; 83(2):262-6Ped

Abstract

There are several causes of infantile colic. The aim of this study was to evaluate, under controlled conditions, whether bovine whey proteins can elicit symptoms of infantile colic in colicky formula-fed infants. The mean age for entering the study was 6.4 weeks and the mean age for colic debut was 3.7 weeks. In 24 of 27 infants with severe colic, the symptoms disappeared when they were given a cow's milk-free diet (Nutramigen). These 24 infants were entered into a double-blind crossover study. The infants (receiving cow's milk-free diet) were given the contents of identical capsules with each meal during day 6. The same procedure was repeated on day 10. The capsules contained either whey protein powder (with Nutramigen added) or human albumin powder (with Nutramigen added). Eighteen infants receiving the whey protein-containing capsules reacted with colic, two infants receiving placebo reacted with colic (P less than .001), and four infants did not react at all. Crying hours per day for the 24 infants were 5.6 hours for formula-fed infants and 0.7 hour for cow's milk-free diet-fed infants (P less than .001). Crying hours per day were 3.2 hours for the infants receiving whey protein capsules and 1.0 hour for those receiving placebo (P less than .001). In conclusion, bovine whey protein can elicit symptoms of infantile colic in colicky formula-fed infants.

Authors+Show Affiliations

Department of Pediatrics, University of Lund, Malmö General Hospital, Sweden.No affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

2913556

Citation

Lothe, L, and T Lindberg. "Cow's Milk Whey Protein Elicits Symptoms of Infantile Colic in Colicky Formula-fed Infants: a Double-blind Crossover Study." Pediatrics, vol. 83, no. 2, 1989, pp. 262-6.
Lothe L, Lindberg T. Cow's milk whey protein elicits symptoms of infantile colic in colicky formula-fed infants: a double-blind crossover study. Pediatrics. 1989;83(2):262-6.
Lothe, L., & Lindberg, T. (1989). Cow's milk whey protein elicits symptoms of infantile colic in colicky formula-fed infants: a double-blind crossover study. Pediatrics, 83(2), pp. 262-6.
Lothe L, Lindberg T. Cow's Milk Whey Protein Elicits Symptoms of Infantile Colic in Colicky Formula-fed Infants: a Double-blind Crossover Study. Pediatrics. 1989;83(2):262-6. PubMed PMID: 2913556.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cow's milk whey protein elicits symptoms of infantile colic in colicky formula-fed infants: a double-blind crossover study. AU - Lothe,L, AU - Lindberg,T, PY - 1989/2/1/pubmed PY - 1989/2/1/medline PY - 1989/2/1/entrez SP - 262 EP - 6 JF - Pediatrics JO - Pediatrics VL - 83 IS - 2 N2 - There are several causes of infantile colic. The aim of this study was to evaluate, under controlled conditions, whether bovine whey proteins can elicit symptoms of infantile colic in colicky formula-fed infants. The mean age for entering the study was 6.4 weeks and the mean age for colic debut was 3.7 weeks. In 24 of 27 infants with severe colic, the symptoms disappeared when they were given a cow's milk-free diet (Nutramigen). These 24 infants were entered into a double-blind crossover study. The infants (receiving cow's milk-free diet) were given the contents of identical capsules with each meal during day 6. The same procedure was repeated on day 10. The capsules contained either whey protein powder (with Nutramigen added) or human albumin powder (with Nutramigen added). Eighteen infants receiving the whey protein-containing capsules reacted with colic, two infants receiving placebo reacted with colic (P less than .001), and four infants did not react at all. Crying hours per day for the 24 infants were 5.6 hours for formula-fed infants and 0.7 hour for cow's milk-free diet-fed infants (P less than .001). Crying hours per day were 3.2 hours for the infants receiving whey protein capsules and 1.0 hour for those receiving placebo (P less than .001). In conclusion, bovine whey protein can elicit symptoms of infantile colic in colicky formula-fed infants. SN - 0031-4005 UR - https://www.unboundmedicine.com/medline/citation/2913556/Cow's_milk_whey_protein_elicits_symptoms_of_infantile_colic_in_colicky_formula_fed_infants:_a_double_blind_crossover_study_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=2913556 DB - PRIME DP - Unbound Medicine ER -