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[Antimicrobial resistance and molecular subtypes of Salmonella typhi and Salmonella paratyphoid isolates from Jiangsu province, 2012-2015].
Zhonghua Liu Xing Bing Xue Za Zhi. 2017 Nov 10; 38(11):1546-1550.ZL

Abstract

Objective:

To retrospectively analyze the antimicrobial resistance phenotype and molecular typing characteristics of Salmonella (S.) typhi and S. paratyphi in Jiangsu province from 2012 to 2015.

Methods:

The samples were collected from typhoid and paratyphoid patients in Jiangsu province. The biochemical identification and serotyping were carried out after isolation and culture. Kirby-Bauer (K-B) testing was used to detect the drug susceptibility of the strains. The molecular typing characteristics of S. typhi and S. paratyphi were analyzed by pulsed field gel electrophoresis (PFGE).

Results:

The resistant rates of 134 S. typhi and S. paratyphi A strains to nalidixic acid were highest (61.2% and 86.7%), while the resistant rates to remaining antibiotics were less than 15.0%. Most of S. typhi and S. paratyphi A strains were resistant to only one antibiotic. Multidrug-resistant (MDR) strains of S. typhi and S. paratyphi A accounted for 2.6% and 13.3% respectively. The composition of the all-sensitive strains of S. typhi increased by 44.3% in 2015, at the same time, there were also MDR S. paratyphi A strains, which were resistant to 5 and 6 antibiotics. S. paratyphi A could be divided into eight molecular patterns by PFGE, showing that the similarity between the MDR strains and other strains was relatively low. The S. paratyphi A strains with same pattern were resistant to same antibiotics. S. typhi could be divided into 68 molecular patterns by PFGE, with large variability between different patterns. There was no corresponding relationship between the patterns and the drug resistance characteristics.

Conclusions:

The overall antibiotic resistance of S. typhi and S. paratyphi A strains showed a decreasing trend, but the number of antibiotics to which they were resistant increased. PFGE patterns of S. typhi showed diversity without correspondence to antibiotic characteristics. PFGE patterns of S. paratyphi A were less with correspondence to antibiotic characteristics. We should pay more attention to key patterns in key areas.

Authors+Show Affiliations

Department of Acute Infectious Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.Department of Acute Infectious Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.Department of Acute Infectious Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.Nanjing Medical University, Nanjing 210029, China.Department of Acute Infectious Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.Department of Acute Infectious Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.Department of Acute Infectious Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.

Pub Type(s)

Journal Article

Language

chi

PubMed ID

29141347

Citation

Kong, X X., et al. "[Antimicrobial Resistance and Molecular Subtypes of Salmonella Typhi and Salmonella Paratyphoid Isolates From Jiangsu Province, 2012-2015]." Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, vol. 38, no. 11, 2017, pp. 1546-1550.
Kong XX, Dong C, Ji H, et al. [Antimicrobial resistance and molecular subtypes of Salmonella typhi and Salmonella paratyphoid isolates from Jiangsu province, 2012-2015]. Zhonghua Liu Xing Bing Xue Za Zhi. 2017;38(11):1546-1550.
Kong, X. X., Dong, C., Ji, H., Wang, Y., Bao, C. C., Huo, X., & Qian, H. M. (2017). [Antimicrobial resistance and molecular subtypes of Salmonella typhi and Salmonella paratyphoid isolates from Jiangsu province, 2012-2015]. Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, 38(11), 1546-1550. https://doi.org/10.3760/cma.j.issn.0254-6450.2017.11.022
Kong XX, et al. [Antimicrobial Resistance and Molecular Subtypes of Salmonella Typhi and Salmonella Paratyphoid Isolates From Jiangsu Province, 2012-2015]. Zhonghua Liu Xing Bing Xue Za Zhi. 2017 Nov 10;38(11):1546-1550. PubMed PMID: 29141347.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Antimicrobial resistance and molecular subtypes of Salmonella typhi and Salmonella paratyphoid isolates from Jiangsu province, 2012-2015]. AU - Kong,X X, AU - Dong,C, AU - Ji,H, AU - Wang,Y, AU - Bao,C C, AU - Huo,X, AU - Qian,H M, PY - 2017/11/17/entrez PY - 2017/11/17/pubmed PY - 2018/3/31/medline KW - Antimicrobial resistance KW - Molecular typing KW - Pulsed field gel electrophoresis KW - Salmonella typhi/paratyphi SP - 1546 EP - 1550 JF - Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi JO - Zhonghua Liu Xing Bing Xue Za Zhi VL - 38 IS - 11 N2 - Objective: To retrospectively analyze the antimicrobial resistance phenotype and molecular typing characteristics of Salmonella (S.) typhi and S. paratyphi in Jiangsu province from 2012 to 2015. Methods: The samples were collected from typhoid and paratyphoid patients in Jiangsu province. The biochemical identification and serotyping were carried out after isolation and culture. Kirby-Bauer (K-B) testing was used to detect the drug susceptibility of the strains. The molecular typing characteristics of S. typhi and S. paratyphi were analyzed by pulsed field gel electrophoresis (PFGE). Results: The resistant rates of 134 S. typhi and S. paratyphi A strains to nalidixic acid were highest (61.2% and 86.7%), while the resistant rates to remaining antibiotics were less than 15.0%. Most of S. typhi and S. paratyphi A strains were resistant to only one antibiotic. Multidrug-resistant (MDR) strains of S. typhi and S. paratyphi A accounted for 2.6% and 13.3% respectively. The composition of the all-sensitive strains of S. typhi increased by 44.3% in 2015, at the same time, there were also MDR S. paratyphi A strains, which were resistant to 5 and 6 antibiotics. S. paratyphi A could be divided into eight molecular patterns by PFGE, showing that the similarity between the MDR strains and other strains was relatively low. The S. paratyphi A strains with same pattern were resistant to same antibiotics. S. typhi could be divided into 68 molecular patterns by PFGE, with large variability between different patterns. There was no corresponding relationship between the patterns and the drug resistance characteristics. Conclusions: The overall antibiotic resistance of S. typhi and S. paratyphi A strains showed a decreasing trend, but the number of antibiotics to which they were resistant increased. PFGE patterns of S. typhi showed diversity without correspondence to antibiotic characteristics. PFGE patterns of S. paratyphi A were less with correspondence to antibiotic characteristics. We should pay more attention to key patterns in key areas. SN - 0254-6450 UR - https://www.unboundmedicine.com/medline/citation/29141347/[Antimicrobial_resistance_and_molecular_subtypes_of_Salmonella_typhi_and_Salmonella_paratyphoid_isolates_from_Jiangsu_province_2012_2015]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0254-6450&year=2017&vol=38&issue=11&fpage=1546 DB - PRIME DP - Unbound Medicine ER -