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Cerebral cortical encephalitis followed by recurrent CNS demyelination in a patient with concomitant anti-MOG and anti-NMDA receptor antibodies.
Mult Scler Relat Disord. 2017 Nov; 18:90-92.MS

Abstract

We report the case of a patient who initially presented with fever, headache and seizure. MRI revealed a fluid attenuation inversion recovery (FLAIR) high-intensity lesion involving the right temporal, parietal and occipital cortex. Afterwards, the patient developed three recurrent episodes, manifested as brainstem encephalitis, optic neuritis and ADEM-like illness successively, indicating demyelination. Both of his serum anti-MOG and CSF anti-NMDAR antibodies were proved positive by transfected cell based assays. We consider our case to have cortical encephalitis due to certain autoimmune mechanism initially, and then developed MOG-antibody mediated recurrent demyelination in the following episodes.

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Authors+Show Affiliations

Zhou L
Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China.
ZhangBao J
Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China.
Li H
Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China.
Li X
Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China.
Huang Y
Department of Ophthalmology, Eye and ENT Hospital, Shanghai Medical College, Fudan University, China.
Wang M
Department of Ophthalmology, Eye and ENT Hospital, Shanghai Medical College, Fudan University, China.
Zhao C
Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China; Department of Neurology, Jing'an District Centre Hospital of Shanghai, China.
Lu J
Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China.
Lu C
Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China.
Li Y
Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China. Electronic address: liyuxin@fudan.edu.cn.
Quan C
Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China. Electronic address: chao_quan@fudan.edu.cn.

MeSH

AdultAnti-N-Methyl-D-Aspartate Receptor EncephalitisAutoantibodiesBiomarkersBrainDemyelinating Autoimmune Diseases, CNSDiagnosis, DifferentialDisease ProgressionHumansMaleMyelin-Oligodendrocyte GlycoproteinReceptors, N-Methyl-D-Aspartate

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

29141829

Citation

Zhou, Lei, et al. "Cerebral Cortical Encephalitis Followed By Recurrent CNS Demyelination in a Patient With Concomitant anti-MOG and anti-NMDA Receptor Antibodies." Multiple Sclerosis and Related Disorders, vol. 18, 2017, pp. 90-92.
Zhou L, ZhangBao J, Li H, et al. Cerebral cortical encephalitis followed by recurrent CNS demyelination in a patient with concomitant anti-MOG and anti-NMDA receptor antibodies. Mult Scler Relat Disord. 2017;18:90-92.
Zhou, L., ZhangBao, J., Li, H., Li, X., Huang, Y., Wang, M., Zhao, C., Lu, J., Lu, C., Li, Y., & Quan, C. (2017). Cerebral cortical encephalitis followed by recurrent CNS demyelination in a patient with concomitant anti-MOG and anti-NMDA receptor antibodies. Multiple Sclerosis and Related Disorders, 18, 90-92. https://doi.org/10.1016/j.msard.2017.09.023
Zhou L, et al. Cerebral Cortical Encephalitis Followed By Recurrent CNS Demyelination in a Patient With Concomitant anti-MOG and anti-NMDA Receptor Antibodies. Mult Scler Relat Disord. 2017;18:90-92. PubMed PMID: 29141829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cerebral cortical encephalitis followed by recurrent CNS demyelination in a patient with concomitant anti-MOG and anti-NMDA receptor antibodies. AU - Zhou,Lei, AU - ZhangBao,Jingzi, AU - Li,Haiqing, AU - Li,Xiaoyang, AU - Huang,Yongheng, AU - Wang,Min, AU - Zhao,Chongbo, AU - Lu,Jiahong, AU - Lu,Chuanzhen, AU - Li,Yuxin, AU - Quan,Chao, Y1 - 2017/09/22/ PY - 2017/06/30/received PY - 2017/09/15/revised PY - 2017/09/20/accepted PY - 2017/11/17/entrez PY - 2017/11/17/pubmed PY - 2018/7/6/medline KW - Autoimmune encephalitis (AIE) KW - Myelin oligodendrocyte glycoprotein (MOG) KW - N-methyl-D-aspartate receptor (NMDAR) SP - 90 EP - 92 JF - Multiple sclerosis and related disorders JO - Mult Scler Relat Disord VL - 18 N2 - We report the case of a patient who initially presented with fever, headache and seizure. MRI revealed a fluid attenuation inversion recovery (FLAIR) high-intensity lesion involving the right temporal, parietal and occipital cortex. Afterwards, the patient developed three recurrent episodes, manifested as brainstem encephalitis, optic neuritis and ADEM-like illness successively, indicating demyelination. Both of his serum anti-MOG and CSF anti-NMDAR antibodies were proved positive by transfected cell based assays. We consider our case to have cortical encephalitis due to certain autoimmune mechanism initially, and then developed MOG-antibody mediated recurrent demyelination in the following episodes. SN - 2211-0356 UR - https://www.unboundmedicine.com/medline/citation/29141829/Cerebral_cortical_encephalitis_followed_by_recurrent_CNS_demyelination_in_a_patient_with_concomitant_anti_MOG_and_anti_NMDA_receptor_antibodies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2211-0348(17)30227-4 DB - PRIME DP - Unbound Medicine ER -