Cerebral cortical encephalitis followed by recurrent CNS demyelination in a patient with concomitant anti-MOG and anti-NMDA receptor antibodies.Mult Scler Relat Disord. 2017 Nov; 18:90-92.MS
Abstract
We report the case of a patient who initially presented with fever, headache and seizure. MRI revealed a fluid attenuation inversion recovery (FLAIR) high-intensity lesion involving the right temporal, parietal and occipital cortex. Afterwards, the patient developed three recurrent episodes, manifested as brainstem encephalitis, optic neuritis and ADEM-like illness successively, indicating demyelination. Both of his serum anti-MOG and CSF anti-NMDAR antibodies were proved positive by transfected cell based assays. We consider our case to have cortical encephalitis due to certain autoimmune mechanism initially, and then developed MOG-antibody mediated recurrent demyelination in the following episodes.
Links
MeSH
Pub Type(s)
Case Reports
Journal Article
Language
eng
PubMed ID
29141829
Citation
Zhou, Lei, et al. "Cerebral Cortical Encephalitis Followed By Recurrent CNS Demyelination in a Patient With Concomitant anti-MOG and anti-NMDA Receptor Antibodies." Multiple Sclerosis and Related Disorders, vol. 18, 2017, pp. 90-92.
Zhou L, ZhangBao J, Li H, et al. Cerebral cortical encephalitis followed by recurrent CNS demyelination in a patient with concomitant anti-MOG and anti-NMDA receptor antibodies. Mult Scler Relat Disord. 2017;18:90-92.
Zhou, L., ZhangBao, J., Li, H., Li, X., Huang, Y., Wang, M., Zhao, C., Lu, J., Lu, C., Li, Y., & Quan, C. (2017). Cerebral cortical encephalitis followed by recurrent CNS demyelination in a patient with concomitant anti-MOG and anti-NMDA receptor antibodies. Multiple Sclerosis and Related Disorders, 18, 90-92. https://doi.org/10.1016/j.msard.2017.09.023
Zhou L, et al. Cerebral Cortical Encephalitis Followed By Recurrent CNS Demyelination in a Patient With Concomitant anti-MOG and anti-NMDA Receptor Antibodies. Mult Scler Relat Disord. 2017;18:90-92. PubMed PMID: 29141829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Cerebral cortical encephalitis followed by recurrent CNS demyelination in a patient with concomitant anti-MOG and anti-NMDA receptor antibodies.
AU - Zhou,Lei,
AU - ZhangBao,Jingzi,
AU - Li,Haiqing,
AU - Li,Xiaoyang,
AU - Huang,Yongheng,
AU - Wang,Min,
AU - Zhao,Chongbo,
AU - Lu,Jiahong,
AU - Lu,Chuanzhen,
AU - Li,Yuxin,
AU - Quan,Chao,
Y1 - 2017/09/22/
PY - 2017/06/30/received
PY - 2017/09/15/revised
PY - 2017/09/20/accepted
PY - 2017/11/17/entrez
PY - 2017/11/17/pubmed
PY - 2018/7/6/medline
KW - Autoimmune encephalitis (AIE)
KW - Myelin oligodendrocyte glycoprotein (MOG)
KW - N-methyl-D-aspartate receptor (NMDAR)
SP - 90
EP - 92
JF - Multiple sclerosis and related disorders
JO - Mult Scler Relat Disord
VL - 18
N2 - We report the case of a patient who initially presented with fever, headache and seizure. MRI revealed a fluid attenuation inversion recovery (FLAIR) high-intensity lesion involving the right temporal, parietal and occipital cortex. Afterwards, the patient developed three recurrent episodes, manifested as brainstem encephalitis, optic neuritis and ADEM-like illness successively, indicating demyelination. Both of his serum anti-MOG and CSF anti-NMDAR antibodies were proved positive by transfected cell based assays. We consider our case to have cortical encephalitis due to certain autoimmune mechanism initially, and then developed MOG-antibody mediated recurrent demyelination in the following episodes.
SN - 2211-0356
UR - https://www.unboundmedicine.com/medline/citation/29141829/Cerebral_cortical_encephalitis_followed_by_recurrent_CNS_demyelination_in_a_patient_with_concomitant_anti_MOG_and_anti_NMDA_receptor_antibodies_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S2211-0348(17)30227-4
DB - PRIME
DP - Unbound Medicine
ER -