Tags

Type your tag names separated by a space and hit enter

Cerebral cortical encephalitis followed by recurrent CNS demyelination in a patient with concomitant anti-MOG and anti-NMDA receptor antibodies.
Mult Scler Relat Disord. 2017 Nov; 18:90-92.MS

Abstract

We report the case of a patient who initially presented with fever, headache and seizure. MRI revealed a fluid attenuation inversion recovery (FLAIR) high-intensity lesion involving the right temporal, parietal and occipital cortex. Afterwards, the patient developed three recurrent episodes, manifested as brainstem encephalitis, optic neuritis and ADEM-like illness successively, indicating demyelination. Both of his serum anti-MOG and CSF anti-NMDAR antibodies were proved positive by transfected cell based assays. We consider our case to have cortical encephalitis due to certain autoimmune mechanism initially, and then developed MOG-antibody mediated recurrent demyelination in the following episodes.

Authors+Show Affiliations

Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China.Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China.Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China.Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China.Department of Ophthalmology, Eye and ENT Hospital, Shanghai Medical College, Fudan University, China.Department of Ophthalmology, Eye and ENT Hospital, Shanghai Medical College, Fudan University, China.Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China; Department of Neurology, Jing'an District Centre Hospital of Shanghai, China.Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China.Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China.Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China. Electronic address: liyuxin@fudan.edu.cn.Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China. Electronic address: chao_quan@fudan.edu.cn.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

29141829

Citation

Zhou, Lei, et al. "Cerebral Cortical Encephalitis Followed By Recurrent CNS Demyelination in a Patient With Concomitant anti-MOG and anti-NMDA Receptor Antibodies." Multiple Sclerosis and Related Disorders, vol. 18, 2017, pp. 90-92.
Zhou L, ZhangBao J, Li H, et al. Cerebral cortical encephalitis followed by recurrent CNS demyelination in a patient with concomitant anti-MOG and anti-NMDA receptor antibodies. Mult Scler Relat Disord. 2017;18:90-92.
Zhou, L., ZhangBao, J., Li, H., Li, X., Huang, Y., Wang, M., Zhao, C., Lu, J., Lu, C., Li, Y., & Quan, C. (2017). Cerebral cortical encephalitis followed by recurrent CNS demyelination in a patient with concomitant anti-MOG and anti-NMDA receptor antibodies. Multiple Sclerosis and Related Disorders, 18, 90-92. https://doi.org/10.1016/j.msard.2017.09.023
Zhou L, et al. Cerebral Cortical Encephalitis Followed By Recurrent CNS Demyelination in a Patient With Concomitant anti-MOG and anti-NMDA Receptor Antibodies. Mult Scler Relat Disord. 2017;18:90-92. PubMed PMID: 29141829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cerebral cortical encephalitis followed by recurrent CNS demyelination in a patient with concomitant anti-MOG and anti-NMDA receptor antibodies. AU - Zhou,Lei, AU - ZhangBao,Jingzi, AU - Li,Haiqing, AU - Li,Xiaoyang, AU - Huang,Yongheng, AU - Wang,Min, AU - Zhao,Chongbo, AU - Lu,Jiahong, AU - Lu,Chuanzhen, AU - Li,Yuxin, AU - Quan,Chao, Y1 - 2017/09/22/ PY - 2017/06/30/received PY - 2017/09/15/revised PY - 2017/09/20/accepted PY - 2017/11/17/entrez PY - 2017/11/17/pubmed PY - 2018/7/6/medline KW - Autoimmune encephalitis (AIE) KW - Myelin oligodendrocyte glycoprotein (MOG) KW - N-methyl-D-aspartate receptor (NMDAR) SP - 90 EP - 92 JF - Multiple sclerosis and related disorders JO - Mult Scler Relat Disord VL - 18 N2 - We report the case of a patient who initially presented with fever, headache and seizure. MRI revealed a fluid attenuation inversion recovery (FLAIR) high-intensity lesion involving the right temporal, parietal and occipital cortex. Afterwards, the patient developed three recurrent episodes, manifested as brainstem encephalitis, optic neuritis and ADEM-like illness successively, indicating demyelination. Both of his serum anti-MOG and CSF anti-NMDAR antibodies were proved positive by transfected cell based assays. We consider our case to have cortical encephalitis due to certain autoimmune mechanism initially, and then developed MOG-antibody mediated recurrent demyelination in the following episodes. SN - 2211-0356 UR - https://www.unboundmedicine.com/medline/citation/29141829/Cerebral_cortical_encephalitis_followed_by_recurrent_CNS_demyelination_in_a_patient_with_concomitant_anti_MOG_and_anti_NMDA_receptor_antibodies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2211-0348(17)30227-4 DB - PRIME DP - Unbound Medicine ER -