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Half-sandwich ruthenium(ii) complexes containing N^N-chelated imino-pyridyl ligands that are selectively toxic to cancer cells.
Chem Commun (Camb). 2017 Nov 28; 53(95):12810-12813.CC

Abstract

Chemotherapy is limited by its poor selectivity towards cancer cells over normal cells. Herein, we designed half-sandwich ruthenium imino-pyridyl complexes [(η6-bz)Ru(N^N)Cl]PF6 to achieve selective cytotoxicity to cancer cells. This kind of ruthenium complex has unique characteristics and is worthy of further exploration in the design of new anticancer drugs.

Authors+Show Affiliations

Institute of Anticancer Agents Development and Theranostic Application, The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, Department of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China. liuzheqd@163.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29143019

Citation

Tian, Meng, et al. "Half-sandwich Ruthenium(ii) Complexes Containing N^N-chelated Imino-pyridyl Ligands That Are Selectively Toxic to Cancer Cells." Chemical Communications (Cambridge, England), vol. 53, no. 95, 2017, pp. 12810-12813.
Tian M, Li J, Zhang S, et al. Half-sandwich ruthenium(ii) complexes containing N^N-chelated imino-pyridyl ligands that are selectively toxic to cancer cells. Chem Commun (Camb). 2017;53(95):12810-12813.
Tian, M., Li, J., Zhang, S., Guo, L., He, X., Kong, D., Zhang, H., & Liu, Z. (2017). Half-sandwich ruthenium(ii) complexes containing N^N-chelated imino-pyridyl ligands that are selectively toxic to cancer cells. Chemical Communications (Cambridge, England), 53(95), 12810-12813. https://doi.org/10.1039/c7cc08270c
Tian M, et al. Half-sandwich Ruthenium(ii) Complexes Containing N^N-chelated Imino-pyridyl Ligands That Are Selectively Toxic to Cancer Cells. Chem Commun (Camb). 2017 Nov 28;53(95):12810-12813. PubMed PMID: 29143019.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Half-sandwich ruthenium(ii) complexes containing N^N-chelated imino-pyridyl ligands that are selectively toxic to cancer cells. AU - Tian,Meng, AU - Li,Juanjuan, AU - Zhang,Shumiao, AU - Guo,Lihua, AU - He,Xiangdong, AU - Kong,Deliang, AU - Zhang,Hairong, AU - Liu,Zhe, PY - 2017/11/17/pubmed PY - 2018/4/6/medline PY - 2017/11/17/entrez SP - 12810 EP - 12813 JF - Chemical communications (Cambridge, England) JO - Chem. Commun. (Camb.) VL - 53 IS - 95 N2 - Chemotherapy is limited by its poor selectivity towards cancer cells over normal cells. Herein, we designed half-sandwich ruthenium imino-pyridyl complexes [(η6-bz)Ru(N^N)Cl]PF6 to achieve selective cytotoxicity to cancer cells. This kind of ruthenium complex has unique characteristics and is worthy of further exploration in the design of new anticancer drugs. SN - 1364-548X UR - https://www.unboundmedicine.com/medline/citation/29143019/Half_sandwich_ruthenium_ii__complexes_containing_N^N_chelated_imino_pyridyl_ligands_that_are_selectively_toxic_to_cancer_cells_ L2 - https://doi.org/10.1039/c7cc08270c DB - PRIME DP - Unbound Medicine ER -