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Half-sandwich ruthenium(ii) complexes containing N^N-chelated imino-pyridyl ligands that are selectively toxic to cancer cells.
Chem Commun (Camb). 2017 Nov 28; 53(95):12810-12813.CC

Abstract

Chemotherapy is limited by its poor selectivity towards cancer cells over normal cells. Herein, we designed half-sandwich ruthenium imino-pyridyl complexes [(η6-bz)Ru(N^N)Cl]PF6 to achieve selective cytotoxicity to cancer cells. This kind of ruthenium complex has unique characteristics and is worthy of further exploration in the design of new anticancer drugs.

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Authors+Show Affiliations

Tian M
Institute of Anticancer Agents Development and Theranostic Application, The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, Department of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China. liuzheqd@163.com.
Li J
No affiliation info available
Zhang S
No affiliation info available
Guo L
No affiliation info available
He X
No affiliation info available
Kong D
No affiliation info available
Zhang H
No affiliation info available
Liu Z
No affiliation info available

MeSH

Antineoplastic AgentsCell Line, TumorCell ProliferationChelating AgentsCoordination ComplexesCrystallography, X-RayDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansIminesLigandsModels, MolecularMolecular StructurePyridinesRutheniumStructure-Activity Relationship

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29143019

Citation

Tian, Meng, et al. "Half-sandwich Ruthenium(ii) Complexes Containing N^N-chelated Imino-pyridyl Ligands That Are Selectively Toxic to Cancer Cells." Chemical Communications (Cambridge, England), vol. 53, no. 95, 2017, pp. 12810-12813.
Tian M, Li J, Zhang S, et al. Half-sandwich ruthenium(ii) complexes containing N^N-chelated imino-pyridyl ligands that are selectively toxic to cancer cells. Chem Commun (Camb). 2017;53(95):12810-12813.
Tian, M., Li, J., Zhang, S., Guo, L., He, X., Kong, D., Zhang, H., & Liu, Z. (2017). Half-sandwich ruthenium(ii) complexes containing N^N-chelated imino-pyridyl ligands that are selectively toxic to cancer cells. Chemical Communications (Cambridge, England), 53(95), 12810-12813. https://doi.org/10.1039/c7cc08270c
Tian M, et al. Half-sandwich Ruthenium(ii) Complexes Containing N^N-chelated Imino-pyridyl Ligands That Are Selectively Toxic to Cancer Cells. Chem Commun (Camb). 2017 Nov 28;53(95):12810-12813. PubMed PMID: 29143019.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Half-sandwich ruthenium(ii) complexes containing N^N-chelated imino-pyridyl ligands that are selectively toxic to cancer cells. AU - Tian,Meng, AU - Li,Juanjuan, AU - Zhang,Shumiao, AU - Guo,Lihua, AU - He,Xiangdong, AU - Kong,Deliang, AU - Zhang,Hairong, AU - Liu,Zhe, PY - 2017/11/17/pubmed PY - 2018/4/6/medline PY - 2017/11/17/entrez SP - 12810 EP - 12813 JF - Chemical communications (Cambridge, England) JO - Chem. Commun. (Camb.) VL - 53 IS - 95 N2 - Chemotherapy is limited by its poor selectivity towards cancer cells over normal cells. Herein, we designed half-sandwich ruthenium imino-pyridyl complexes [(η6-bz)Ru(N^N)Cl]PF6 to achieve selective cytotoxicity to cancer cells. This kind of ruthenium complex has unique characteristics and is worthy of further exploration in the design of new anticancer drugs. SN - 1364-548X UR - https://www.unboundmedicine.com/medline/citation/29143019/Half_sandwich_ruthenium_ii__complexes_containing_N^N_chelated_imino_pyridyl_ligands_that_are_selectively_toxic_to_cancer_cells_ L2 - https://doi.org/10.1039/c7cc08270c DB - PRIME DP - Unbound Medicine ER -