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Update on the Treatment of Uveitis in Patients with Juvenile Idiopathic Arthritis: A Review.
Adv Ther. 2017 12; 34(12):2558-2565.AT

Abstract

Chronic uveitis is a common extra-articular manifestation of juvenile idiopathic arthritis. The classic clinical picture is one of chronic anterior uveitis, which usually remains asymptomatic until ocular complications arise. The risk of uveitis is increased in girls with an early onset of oligoarthritis and positive antinuclear antibodies. Even though the inflammation in patients with juvenile idiopathic arthritis is initially limited in the anterior part of the eye, chronic active inflammation may eventually cause significant damage to the posterior pole. Complications may include band keratopathy, cataract, secondary glaucoma, posterior synechiae, cystoid macular edema, and hypotony. The cooperation of ophthalmologists with rheumatologists may help define the best treatment plan. The ophthalmic therapeutic regimen includes topical corticosteroids and mydriatics, while in severe cases immunosuppressive and biological agents are introduced. Surgical management of complications might be needed.

Authors+Show Affiliations

Department of Ophthalmology, University of Ioannina, Ioannina, Greece.Department of Ophthalmology, University of Ioannina, Ioannina, Greece. katsanos@cc.uoi.gr.Ophthalmica Institute, Thessaloniki, Greece.Department of Ophthalmology, University of Ioannina, Ioannina, Greece.1st and 3rd University Departments of Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29143927

Citation

Asproudis, Ioannis, et al. "Update On the Treatment of Uveitis in Patients With Juvenile Idiopathic Arthritis: a Review." Advances in Therapy, vol. 34, no. 12, 2017, pp. 2558-2565.
Asproudis I, Katsanos A, Kozeis N, et al. Update on the Treatment of Uveitis in Patients with Juvenile Idiopathic Arthritis: A Review. Adv Ther. 2017;34(12):2558-2565.
Asproudis, I., Katsanos, A., Kozeis, N., Tantou, A., & Konstas, A. G. (2017). Update on the Treatment of Uveitis in Patients with Juvenile Idiopathic Arthritis: A Review. Advances in Therapy, 34(12), 2558-2565. https://doi.org/10.1007/s12325-017-0635-3
Asproudis I, et al. Update On the Treatment of Uveitis in Patients With Juvenile Idiopathic Arthritis: a Review. Adv Ther. 2017;34(12):2558-2565. PubMed PMID: 29143927.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Update on the Treatment of Uveitis in Patients with Juvenile Idiopathic Arthritis: A Review. AU - Asproudis,Ioannis, AU - Katsanos,Andreas, AU - Kozeis,Nikolaos, AU - Tantou,Alexandra, AU - Konstas,Anastasios G, Y1 - 2017/11/16/ PY - 2017/08/18/received PY - 2017/11/17/pubmed PY - 2018/5/22/medline PY - 2017/11/17/entrez KW - Anti-TNF KW - Biological agents KW - DMARDS KW - JIA KW - Juvenile idiopathic arthritis KW - Methotrexate KW - Topical steroids KW - Uveitis SP - 2558 EP - 2565 JF - Advances in therapy JO - Adv Ther VL - 34 IS - 12 N2 - Chronic uveitis is a common extra-articular manifestation of juvenile idiopathic arthritis. The classic clinical picture is one of chronic anterior uveitis, which usually remains asymptomatic until ocular complications arise. The risk of uveitis is increased in girls with an early onset of oligoarthritis and positive antinuclear antibodies. Even though the inflammation in patients with juvenile idiopathic arthritis is initially limited in the anterior part of the eye, chronic active inflammation may eventually cause significant damage to the posterior pole. Complications may include band keratopathy, cataract, secondary glaucoma, posterior synechiae, cystoid macular edema, and hypotony. The cooperation of ophthalmologists with rheumatologists may help define the best treatment plan. The ophthalmic therapeutic regimen includes topical corticosteroids and mydriatics, while in severe cases immunosuppressive and biological agents are introduced. Surgical management of complications might be needed. SN - 1865-8652 UR - https://www.unboundmedicine.com/medline/citation/29143927/Update_on_the_Treatment_of_Uveitis_in_Patients_with_Juvenile_Idiopathic_Arthritis:_A_Review_ DB - PRIME DP - Unbound Medicine ER -