Tags

Type your tag names separated by a space and hit enter

High plasma 25-hydroxyvitamin D and high risk of nonmelanoma skin cancer: a Mendelian randomization study of 97 849 individuals.
Br J Dermatol. 2018 06; 178(6):1388-1395.BJ

Abstract

BACKGROUND

High plasma 25-hydroxyvitamin D [25(OH)D] concentration has been associated observationally with a high risk of nonmelanoma skin cancer (NMSC), whereas many studies suggest that vitamin D could have a protective effect against cancer. The true association between vitamin D and risk of skin cancer remains unclear.

OBJECTIVES

To test the hypothesis that genetically high plasma 25(OH)D protects against NMSC.

METHODS

We included 103 084 individuals from the Danish general population, of whom 35 298 had plasma 25(OH)D measured and 97 849 were genotyped for four genetic variants near DHCR7 and CYP2R1 associated with 25(OH)D concentrations. We tested the association between plasma 25(OH)D levels and NMSC observationally and between genetically determined 25(OH)D levels and NMSC, using an instrumental variable approach.

RESULTS

Multivariate-adjusted hazard ratios of NMSC were 3·27 [95% confidence interval (CI) 2·22-4·84] for plasma 25(OH)D ≥ 50 nmol L-1 vs. < 25 nmol L-1 . Genetic variants around DHCR7 and CYP2R1 were associated with up to 8·2 nmol L-1 higher 25(OH)D concentrations (F = 314). The odds ratio (OR) for a genetically determined 20 nmol L-1 higher plasma 25(OH)D was 1·11 (95% CI 0·91-1·35) for NMSC, with a corresponding observational multivariable adjusted OR of 1·13 (95% CI 1·10-1·17).

CONCLUSIONS

Genetically determined high 25(OH)D levels did not appear to protect against NMSC, whereas high plasma 25(OH)D concentrations were associated with an observational high risk of NMSC. Thus, the observational association likely reflects confounding by sun exposure rather than causality.

Authors+Show Affiliations

Department of Clinical Biochemistry and the Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Denmark. Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.Department of Clinical Biochemistry and the Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Denmark. Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.Department of Clinical Biochemistry and the Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Denmark. Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

29143981

Citation

Winsløw, U C., et al. "High Plasma 25-hydroxyvitamin D and High Risk of Nonmelanoma Skin Cancer: a Mendelian Randomization Study of 97 849 Individuals." The British Journal of Dermatology, vol. 178, no. 6, 2018, pp. 1388-1395.
Winsløw UC, Nordestgaard BG, Afzal S. High plasma 25-hydroxyvitamin D and high risk of nonmelanoma skin cancer: a Mendelian randomization study of 97 849 individuals. Br J Dermatol. 2018;178(6):1388-1395.
Winsløw, U. C., Nordestgaard, B. G., & Afzal, S. (2018). High plasma 25-hydroxyvitamin D and high risk of nonmelanoma skin cancer: a Mendelian randomization study of 97 849 individuals. The British Journal of Dermatology, 178(6), 1388-1395. https://doi.org/10.1111/bjd.16127
Winsløw UC, Nordestgaard BG, Afzal S. High Plasma 25-hydroxyvitamin D and High Risk of Nonmelanoma Skin Cancer: a Mendelian Randomization Study of 97 849 Individuals. Br J Dermatol. 2018;178(6):1388-1395. PubMed PMID: 29143981.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High plasma 25-hydroxyvitamin D and high risk of nonmelanoma skin cancer: a Mendelian randomization study of 97 849 individuals. AU - Winsløw,U C, AU - Nordestgaard,B G, AU - Afzal,S, Y1 - 2018/04/14/ PY - 2017/11/12/accepted PY - 2017/11/17/pubmed PY - 2019/11/5/medline PY - 2017/11/17/entrez SP - 1388 EP - 1395 JF - The British journal of dermatology JO - Br. J. Dermatol. VL - 178 IS - 6 N2 - BACKGROUND: High plasma 25-hydroxyvitamin D [25(OH)D] concentration has been associated observationally with a high risk of nonmelanoma skin cancer (NMSC), whereas many studies suggest that vitamin D could have a protective effect against cancer. The true association between vitamin D and risk of skin cancer remains unclear. OBJECTIVES: To test the hypothesis that genetically high plasma 25(OH)D protects against NMSC. METHODS: We included 103 084 individuals from the Danish general population, of whom 35 298 had plasma 25(OH)D measured and 97 849 were genotyped for four genetic variants near DHCR7 and CYP2R1 associated with 25(OH)D concentrations. We tested the association between plasma 25(OH)D levels and NMSC observationally and between genetically determined 25(OH)D levels and NMSC, using an instrumental variable approach. RESULTS: Multivariate-adjusted hazard ratios of NMSC were 3·27 [95% confidence interval (CI) 2·22-4·84] for plasma 25(OH)D ≥ 50 nmol L-1 vs. < 25 nmol L-1 . Genetic variants around DHCR7 and CYP2R1 were associated with up to 8·2 nmol L-1 higher 25(OH)D concentrations (F = 314). The odds ratio (OR) for a genetically determined 20 nmol L-1 higher plasma 25(OH)D was 1·11 (95% CI 0·91-1·35) for NMSC, with a corresponding observational multivariable adjusted OR of 1·13 (95% CI 1·10-1·17). CONCLUSIONS: Genetically determined high 25(OH)D levels did not appear to protect against NMSC, whereas high plasma 25(OH)D concentrations were associated with an observational high risk of NMSC. Thus, the observational association likely reflects confounding by sun exposure rather than causality. SN - 1365-2133 UR - https://www.unboundmedicine.com/medline/citation/29143981/High_plasma_25_hydroxyvitamin_D_and_high_risk_of_nonmelanoma_skin_cancer:_a_Mendelian_randomization_study_of_97_849_individuals_ L2 - https://doi.org/10.1111/bjd.16127 DB - PRIME DP - Unbound Medicine ER -