Tags

Type your tag names separated by a space and hit enter

Sleep quality and methylation status of selected tumor suppressor genes among nurses and midwives.
Chronobiol Int. 2018 01; 35(1):122-131.CI

Abstract

Chronic sleep restriction may affect metabolism, hormone secretion patterns and inflammatory responses. Limited reports suggest also epigenetic effects, such as changes in DNA methylation profiles. The study aims to assess the potential association between poor sleep quality or sleep duration and the levels of 5-methylcytosine in the promoter regions of selected tumor suppressor genes. A cross-sectional study was conducted on 710 nurses and midwives aged 40-60 years. Data from interviews regarding sleep habits and potential confounders were used. The methylation status of tumor suppressor genes was determined via qMSP reactions using DNA samples derived from leucocytes. No significant findings were observed in the total study population or in the two subgroups of women stratified by the current system of work. A borderline significance association was observed between a shorter duration of sleep and an increased methylation level in CDKN2A among day working nurses and midwives. Further studies are warranted to explore this under-investigated topic.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Bukowska-Damska A
a Department of Environmental Epidemiology , Nofer Institute of Occupational Medicine , Lodz , Poland.
Reszka E
b Department of Molecular Genetics and Epigenetics , Nofer Institute of Occupational Medicine , Lodz , Poland.
Kaluzny P
a Department of Environmental Epidemiology , Nofer Institute of Occupational Medicine , Lodz , Poland.
Wieczorek E
b Department of Molecular Genetics and Epigenetics , Nofer Institute of Occupational Medicine , Lodz , Poland.
Przybek M
b Department of Molecular Genetics and Epigenetics , Nofer Institute of Occupational Medicine , Lodz , Poland.
Zienolddiny S
c National Institute of Occupational Health , Oslo , Norway.
Peplonska B
a Department of Environmental Epidemiology , Nofer Institute of Occupational Medicine , Lodz , Poland.

MeSH

AdultCircadian RhythmCross-Sectional StudiesFemaleGenes, Tumor SuppressorHumansMiddle AgedMidwiferyNursesPromoter Regions, GeneticSleepSleep Initiation and Maintenance DisordersTime FactorsWork Schedule Tolerance

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29144154

Citation

Bukowska-Damska, Agnieszka, et al. "Sleep Quality and Methylation Status of Selected Tumor Suppressor Genes Among Nurses and Midwives." Chronobiology International, vol. 35, no. 1, 2018, pp. 122-131.
Bukowska-Damska A, Reszka E, Kaluzny P, et al. Sleep quality and methylation status of selected tumor suppressor genes among nurses and midwives. Chronobiol Int. 2018;35(1):122-131.
Bukowska-Damska, A., Reszka, E., Kaluzny, P., Wieczorek, E., Przybek, M., Zienolddiny, S., & Peplonska, B. (2018). Sleep quality and methylation status of selected tumor suppressor genes among nurses and midwives. Chronobiology International, 35(1), 122-131. https://doi.org/10.1080/07420528.2017.1376219
Bukowska-Damska A, et al. Sleep Quality and Methylation Status of Selected Tumor Suppressor Genes Among Nurses and Midwives. Chronobiol Int. 2018;35(1):122-131. PubMed PMID: 29144154.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sleep quality and methylation status of selected tumor suppressor genes among nurses and midwives. AU - Bukowska-Damska,Agnieszka, AU - Reszka,Edyta, AU - Kaluzny,Pawel, AU - Wieczorek,Edyta, AU - Przybek,Monika, AU - Zienolddiny,Shanbeh, AU - Peplonska,Beata, Y1 - 2017/11/16/ PY - 2017/11/17/pubmed PY - 2019/3/22/medline PY - 2017/11/17/entrez KW - DNA methylation KW - nurses and midwives KW - shiftwork KW - tumor suppressor genes SP - 122 EP - 131 JF - Chronobiology international JO - Chronobiol Int VL - 35 IS - 1 N2 - Chronic sleep restriction may affect metabolism, hormone secretion patterns and inflammatory responses. Limited reports suggest also epigenetic effects, such as changes in DNA methylation profiles. The study aims to assess the potential association between poor sleep quality or sleep duration and the levels of 5-methylcytosine in the promoter regions of selected tumor suppressor genes. A cross-sectional study was conducted on 710 nurses and midwives aged 40-60 years. Data from interviews regarding sleep habits and potential confounders were used. The methylation status of tumor suppressor genes was determined via qMSP reactions using DNA samples derived from leucocytes. No significant findings were observed in the total study population or in the two subgroups of women stratified by the current system of work. A borderline significance association was observed between a shorter duration of sleep and an increased methylation level in CDKN2A among day working nurses and midwives. Further studies are warranted to explore this under-investigated topic. SN - 1525-6073 UR - https://www.unboundmedicine.com/medline/citation/29144154/Sleep_quality_and_methylation_status_of_selected_tumor_suppressor_genes_among_nurses_and_midwives_ DB - PRIME DP - Unbound Medicine ER -