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Transcription factors Atf1 and Sty1 promote stress tolerance under nitrosative stress in Schizosaccharomyces pombe.
Microbiol Res. 2018 Jan; 206:82-90.MR

Abstract

Nitric Oxide (NO) and its associated reactive nitrogen species (RNS) produce nitrosative stress under various pathophysiological conditions in eukaryotes. The fission yeast Schizosaccharomyces pombe regulates stress response mainly through the Sty1-Atf1 MAP Kinase pathway. The present study deals with the role of transcription factor Atf1 and Sty1 in S. pombe under nitrosative stress. In this study, exposure to an NO donor resulted in S-phase slowdown with associated mitotic block in S. pombe. Deletion of sty1 and atf1 in S. pombe had differential growth sensitivity towards NO donor. Both Sty1 and Atf1 were involved in regulating mitotic slowdown in S. pombe under nitrosative stress. Experimental data obtained in this study reveals a novel role of Atf1 in initiating the replication slowdown in S. pombe under nitrosative stress. Both Sty1 and Atf1 were accumulated in the nucleus in S. pombe under nitrosative stress in a concentration and time dependent manner. Atf1 is also found to be nuclear delocalized under longer nitrosative stress.

Authors+Show Affiliations

Department of Biochemistry, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700019, West Bengal, India.Department of Biochemistry, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700019, West Bengal, India.Department of Biochemistry, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700019, West Bengal, India.Department of Biochemistry, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700019, West Bengal, India. Electronic address: ghoshs71@hotmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29146263

Citation

Kar, Puranjoy, et al. "Transcription Factors Atf1 and Sty1 Promote Stress Tolerance Under Nitrosative Stress in Schizosaccharomyces Pombe." Microbiological Research, vol. 206, 2018, pp. 82-90.
Kar P, Biswas P, Patra SK, et al. Transcription factors Atf1 and Sty1 promote stress tolerance under nitrosative stress in Schizosaccharomyces pombe. Microbiol Res. 2018;206:82-90.
Kar, P., Biswas, P., Patra, S. K., & Ghosh, S. (2018). Transcription factors Atf1 and Sty1 promote stress tolerance under nitrosative stress in Schizosaccharomyces pombe. Microbiological Research, 206, 82-90. https://doi.org/10.1016/j.micres.2017.10.002
Kar P, et al. Transcription Factors Atf1 and Sty1 Promote Stress Tolerance Under Nitrosative Stress in Schizosaccharomyces Pombe. Microbiol Res. 2018;206:82-90. PubMed PMID: 29146263.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transcription factors Atf1 and Sty1 promote stress tolerance under nitrosative stress in Schizosaccharomyces pombe. AU - Kar,Puranjoy, AU - Biswas,Pranjal, AU - Patra,Sourav Kumar, AU - Ghosh,Sanjay, Y1 - 2017/10/12/ PY - 2017/05/29/received PY - 2017/08/28/revised PY - 2017/10/07/accepted PY - 2017/11/18/entrez PY - 2017/11/18/pubmed PY - 2018/6/30/medline KW - Atf1 KW - Nitric oxide KW - Nitrosative stress KW - Nuclear localization KW - Schizosaccharomyces pombe KW - Sty1 SP - 82 EP - 90 JF - Microbiological research JO - Microbiol Res VL - 206 N2 - Nitric Oxide (NO) and its associated reactive nitrogen species (RNS) produce nitrosative stress under various pathophysiological conditions in eukaryotes. The fission yeast Schizosaccharomyces pombe regulates stress response mainly through the Sty1-Atf1 MAP Kinase pathway. The present study deals with the role of transcription factor Atf1 and Sty1 in S. pombe under nitrosative stress. In this study, exposure to an NO donor resulted in S-phase slowdown with associated mitotic block in S. pombe. Deletion of sty1 and atf1 in S. pombe had differential growth sensitivity towards NO donor. Both Sty1 and Atf1 were involved in regulating mitotic slowdown in S. pombe under nitrosative stress. Experimental data obtained in this study reveals a novel role of Atf1 in initiating the replication slowdown in S. pombe under nitrosative stress. Both Sty1 and Atf1 were accumulated in the nucleus in S. pombe under nitrosative stress in a concentration and time dependent manner. Atf1 is also found to be nuclear delocalized under longer nitrosative stress. SN - 1618-0623 UR - https://www.unboundmedicine.com/medline/citation/29146263/Transcription_factors_Atf1_and_Sty1_promote_stress_tolerance_under_nitrosative_stress_in_Schizosaccharomyces_pombe_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-5013(17)30499-8 DB - PRIME DP - Unbound Medicine ER -