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Euterpe oleracea pulp extract: Chemical analyses, antibiofilm activity against Staphylococcus aureus, cytotoxicity and interference on the activity of antimicrobial drugs.
Microb Pathog. 2018 Jan; 114:29-35.MP

Abstract

Euterpe oleracea (Açaí) fruit are widely consumed at the Brazilian Amazon region, and biological potentials such as immunomodulatory and antioxidant have been described for its extracts. However, its antimicrobial properties remain poorly investigated. Here, the antimicrobial and antibiofilm activities of the methanolic extract of an artisanally-manufactured açaí pulp (MEAP) were evaluated against clinical isolates of Staphylococcus aureus. Besides, MEAP interference on the activity of antimicrobial drugs of clinical relevance was explored, and its cytotoxicity against hepatocellular carcinoma cells (HepG2) was investigated. Biochemical and physicochemical properties of the pulp were investigated, and the presence of polyphenols on the extract was confirmed. For the first time, we report that the methanolic extract of açaí pulp is effective against planktonic cells and biofilms of S. aureus, and also decreased the proliferation of HepG2 cells. Statistically significant synergism was observed when the extract was combined to the tested antimicrobials except for erythromycin, and all biochemical and physicochemical parameters ranged within the accepted values established by the Brazilian legislation. Our data open doors for more studies on the antimicrobial activity of phytomolecules isolated from Euterpe oleracea extracts, and also for its combined use with antimicrobial drugs.

Authors+Show Affiliations

Health Sciences Faculty, University Vale do Rio Doce, Brazil; Integrated Pharmacology and Drug Interactions Research Group (GPqFAR), MG, Brazil. Electronic address: marcus.souza@univale.br.Faculty of Pharmacy, Federal University of Minas Gerais, Brazil; Integrated Pharmacology and Drug Interactions Research Group (GPqFAR), MG, Brazil.René Rachou Institute, FIOCRUZ Minas, Brazil.Faculty of Pharmacy, Federal University of Minas Gerais, Brazil.Health Sciences Faculty, University Vale do Rio Doce, Brazil; Integrated Pharmacology and Drug Interactions Research Group (GPqFAR), MG, Brazil.René Rachou Institute, FIOCRUZ Minas, Brazil; Health and Human Development Faculty, Santo Agostinho Institute, Brazil; Integrated Pharmacology and Drug Interactions Research Group (GPqFAR), MG, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29146496

Citation

Dias-Souza, Marcus Vinícius, et al. "Euterpe Oleracea Pulp Extract: Chemical Analyses, Antibiofilm Activity Against Staphylococcus Aureus, Cytotoxicity and Interference On the Activity of Antimicrobial Drugs." Microbial Pathogenesis, vol. 114, 2018, pp. 29-35.
Dias-Souza MV, Dos Santos RM, Cerávolo IP, et al. Euterpe oleracea pulp extract: Chemical analyses, antibiofilm activity against Staphylococcus aureus, cytotoxicity and interference on the activity of antimicrobial drugs. Microb Pathog. 2018;114:29-35.
Dias-Souza, M. V., Dos Santos, R. M., Cerávolo, I. P., Cosenza, G., Ferreira Marçal, P. H., & Figueiredo, F. J. B. (2018). Euterpe oleracea pulp extract: Chemical analyses, antibiofilm activity against Staphylococcus aureus, cytotoxicity and interference on the activity of antimicrobial drugs. Microbial Pathogenesis, 114, 29-35. https://doi.org/10.1016/j.micpath.2017.11.006
Dias-Souza MV, et al. Euterpe Oleracea Pulp Extract: Chemical Analyses, Antibiofilm Activity Against Staphylococcus Aureus, Cytotoxicity and Interference On the Activity of Antimicrobial Drugs. Microb Pathog. 2018;114:29-35. PubMed PMID: 29146496.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Euterpe oleracea pulp extract: Chemical analyses, antibiofilm activity against Staphylococcus aureus, cytotoxicity and interference on the activity of antimicrobial drugs. AU - Dias-Souza,Marcus Vinícius, AU - Dos Santos,Renan Martins, AU - Cerávolo,Isabela Penna, AU - Cosenza,Gustavo, AU - Ferreira Marçal,Pedro Henrique, AU - Figueiredo,Flávio Jr Barbosa, Y1 - 2017/11/13/ PY - 2017/06/11/received PY - 2017/11/09/accepted PY - 2017/11/18/pubmed PY - 2018/8/14/medline PY - 2017/11/18/entrez KW - Antimicrobial KW - Cytotoxicity KW - Euterpe oleracea KW - Staphylococcus SP - 29 EP - 35 JF - Microbial pathogenesis JO - Microb Pathog VL - 114 N2 - Euterpe oleracea (Açaí) fruit are widely consumed at the Brazilian Amazon region, and biological potentials such as immunomodulatory and antioxidant have been described for its extracts. However, its antimicrobial properties remain poorly investigated. Here, the antimicrobial and antibiofilm activities of the methanolic extract of an artisanally-manufactured açaí pulp (MEAP) were evaluated against clinical isolates of Staphylococcus aureus. Besides, MEAP interference on the activity of antimicrobial drugs of clinical relevance was explored, and its cytotoxicity against hepatocellular carcinoma cells (HepG2) was investigated. Biochemical and physicochemical properties of the pulp were investigated, and the presence of polyphenols on the extract was confirmed. For the first time, we report that the methanolic extract of açaí pulp is effective against planktonic cells and biofilms of S. aureus, and also decreased the proliferation of HepG2 cells. Statistically significant synergism was observed when the extract was combined to the tested antimicrobials except for erythromycin, and all biochemical and physicochemical parameters ranged within the accepted values established by the Brazilian legislation. Our data open doors for more studies on the antimicrobial activity of phytomolecules isolated from Euterpe oleracea extracts, and also for its combined use with antimicrobial drugs. SN - 1096-1208 UR - https://www.unboundmedicine.com/medline/citation/29146496/Euterpe_oleracea_pulp_extract:_Chemical_analyses_antibiofilm_activity_against_Staphylococcus_aureus_cytotoxicity_and_interference_on_the_activity_of_antimicrobial_drugs_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0882-4010(17)30684-8 DB - PRIME DP - Unbound Medicine ER -