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Lipoprotein(a) Associated Molecules are Prominent Components in Plasma and Valve Leaflets in Calcific Aortic Valve Stenosis.
JACC Basic Transl Sci. 2017 Jun; 2(3):229-240.JB

Abstract

The LPA gene is the only monogenetic risk factor for calcific aortic valve stenosis (CAVS). Oxidized phospholipids (OxPL) and lysophosphatidic acid generated by autotaxin (ATX) from OxPL are pro-inflammatory. Aortic valve leaflets were categorized pathologically from Both ATX-apoB and ATX-apo(a) were measureable in plasma. Lp(a), autotaxin, OxPL and MDA epitopes progressively increased in immunostaining (p<0.001 for all). Six species of OxPL and LysoPA were identified following extraction from valve leaflets. The presence of a constellation of pathologically-linked, Lp(a)-associated molecules in plasma and in aortic valve leaflets of patients with CAVS suggest that Lp(a) is a key etiological factor in CAVS.

Authors+Show Affiliations

Department of Laboratory Medicine, Robert-Bosch-Hospital, Germany.Cardiac Sciences Program, University of Manitoba and Institute of Cardiovascular Sciences, St. Boniface Hospital.Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology and University of Tuebingen, Stuttgart, Germany.Cardiac Sciences Program, University of Manitoba and Institute of Cardiovascular Sciences, St. Boniface Hospital.Cardiac Sciences Program, University of Manitoba and Institute of Cardiovascular Sciences, St. Boniface Hospital.Department of Laboratory Medicine, Robert-Bosch-Hospital, Germany.Department of Laboratory Medicine, Robert-Bosch-Hospital, Germany.Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology and University of Tuebingen, Stuttgart, Germany.Division of Cardiovascular Medicine, Sulpizio Cardiovascular Center, University of California San Diego, La Jolla CA.Department of Cardiovascular Surgery, Robert-Bosch-Hospital, Germany.Division of Endocrinology and Metabolism, University of California San Diego, La Jolla CA.Division of Cardiovascular Medicine, Sulpizio Cardiovascular Center, University of California San Diego, La Jolla CA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29147686

Citation

Torzewski, Michael, et al. "Lipoprotein(a) Associated Molecules Are Prominent Components in Plasma and Valve Leaflets in Calcific Aortic Valve Stenosis." JACC. Basic to Translational Science, vol. 2, no. 3, 2017, pp. 229-240.
Torzewski M, Ravandi A, Yeang C, et al. Lipoprotein(a) Associated Molecules are Prominent Components in Plasma and Valve Leaflets in Calcific Aortic Valve Stenosis. JACC Basic Transl Sci. 2017;2(3):229-240.
Torzewski, M., Ravandi, A., Yeang, C., Edel, A., Bhindi, R., Kath, S., Twardowski, L., Schmid, J., Yang, X., Franke, U. F. W., Witztum, J. L., & Tsimikas, S. (2017). Lipoprotein(a) Associated Molecules are Prominent Components in Plasma and Valve Leaflets in Calcific Aortic Valve Stenosis. JACC. Basic to Translational Science, 2(3), 229-240. https://doi.org/10.1016/j.jacbts.2017.02.004
Torzewski M, et al. Lipoprotein(a) Associated Molecules Are Prominent Components in Plasma and Valve Leaflets in Calcific Aortic Valve Stenosis. JACC Basic Transl Sci. 2017;2(3):229-240. PubMed PMID: 29147686.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipoprotein(a) Associated Molecules are Prominent Components in Plasma and Valve Leaflets in Calcific Aortic Valve Stenosis. AU - Torzewski,Michael, AU - Ravandi,Amir, AU - Yeang,Calvin, AU - Edel,Andrea, AU - Bhindi,Rahul, AU - Kath,Stefan, AU - Twardowski,Laura, AU - Schmid,Jens, AU - Yang,Xiaohong, AU - Franke,Ulrich F W, AU - Witztum,Joseph L, AU - Tsimikas,Sotirios, Y1 - 2017/06/26/ PY - 2017/11/18/entrez PY - 2017/11/18/pubmed PY - 2017/11/18/medline KW - Lp(a) KW - aortic valve stenosis KW - autotaxin KW - inflammation KW - oxidation-specific epitopes SP - 229 EP - 240 JF - JACC. Basic to translational science JO - JACC Basic Transl Sci VL - 2 IS - 3 N2 - The LPA gene is the only monogenetic risk factor for calcific aortic valve stenosis (CAVS). Oxidized phospholipids (OxPL) and lysophosphatidic acid generated by autotaxin (ATX) from OxPL are pro-inflammatory. Aortic valve leaflets were categorized pathologically from Both ATX-apoB and ATX-apo(a) were measureable in plasma. Lp(a), autotaxin, OxPL and MDA epitopes progressively increased in immunostaining (p<0.001 for all). Six species of OxPL and LysoPA were identified following extraction from valve leaflets. The presence of a constellation of pathologically-linked, Lp(a)-associated molecules in plasma and in aortic valve leaflets of patients with CAVS suggest that Lp(a) is a key etiological factor in CAVS. SN - 2452-302X UR - https://www.unboundmedicine.com/medline/citation/29147686/Lipoprotein_a__Associated_Molecules_are_Prominent_Components_in_Plasma_and_Valve_Leaflets_in_Calcific_Aortic_Valve_Stenosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2452-302X(17)30094-3 DB - PRIME DP - Unbound Medicine ER -