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Adherence to Mediterranean diet and subjective cognitive function in men.

Abstract

Benefits of a Mediterranean diet for cognition have been suggested, but epidemiologic studies have been relatively small and of limited duration. To prospectively assess the association between long-term adherence to a Mediterranean dietary pattern and self-reported subjective cognitive function (SCF). Prospective observational study. The Health Professionals' Follow-up Study, a prospective cohort of 51,529 men, 40-75 years of age when enrolled in 1986, of whom 27,842 were included in the primary analysis. Mediterranean diet (MD) score, computed from the mean of five food frequency questionnaires, assessed every 4 years from 1986 to 2002. Self-reported SCF assessed by a 6-item questionnaire in 2008 and 2012, and validated by association with genetic variants in apolipoprotein-4. Using the average of 2008 and 2012 SCF scores, 38.0% of men were considered to have moderate memory scores and 7.3% were considered to have poor scores. In a multivariate model, compared with men having a MD score in the lowest quintile, those in the highest quintile had a 36% lower odds of a poor SCF score (odds ratio 0.64, 95% CI 0.55-0.75; P, trend < 0.001) and a 24% lower odds of a moderate SCF score (OR 0.76, 95% CI 0.70-0.83; P, trend < 0.001). Both remote and more recent diet contributed to this relation. Associations were only slightly weaker using baseline dietary data and a lag of 22 years. Long-term adherence to the Mediterranean diet pattern was strongly related to lower subjective cognitive function. These findings provide further evidence that a healthy dietary pattern may prevent or delay cognitive decline.

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  • Authors+Show Affiliations

    ,

    Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA. ambika.bhushan@gmail.com. Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA. ambika.bhushan@gmail.com.

    ,

    Department of Nutrition, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA.

    ,

    Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA. Department of Nutrition, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA.

    ,

    Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA. Department of Nutrition, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA.

    ,

    Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA.

    Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA. Department of Nutrition, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA.

    Source

    European journal of epidemiology 33:2 2018 02 pg 223-234

    MeSH

    Adult
    Aged
    Alzheimer Disease
    Cognition
    Cognition Disorders
    Dementia
    Diet, Mediterranean
    Follow-Up Studies
    Humans
    Life Style
    Male
    Middle Aged
    Neuropsychological Tests
    Patient Compliance
    Prospective Studies
    Surveys and Questionnaires
    United States

    Pub Type(s)

    Journal Article
    Observational Study
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    29147948

    Citation

    Bhushan, Ambika, et al. "Adherence to Mediterranean Diet and Subjective Cognitive Function in Men." European Journal of Epidemiology, vol. 33, no. 2, 2018, pp. 223-234.
    Bhushan A, Fondell E, Ascherio A, et al. Adherence to Mediterranean diet and subjective cognitive function in men. Eur J Epidemiol. 2018;33(2):223-234.
    Bhushan, A., Fondell, E., Ascherio, A., Yuan, C., Grodstein, F., & Willett, W. (2018). Adherence to Mediterranean diet and subjective cognitive function in men. European Journal of Epidemiology, 33(2), pp. 223-234. doi:10.1007/s10654-017-0330-3.
    Bhushan A, et al. Adherence to Mediterranean Diet and Subjective Cognitive Function in Men. Eur J Epidemiol. 2018;33(2):223-234. PubMed PMID: 29147948.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Adherence to Mediterranean diet and subjective cognitive function in men. AU - Bhushan,Ambika, AU - Fondell,Elinor, AU - Ascherio,Alberto, AU - Yuan,Changzheng, AU - Grodstein,Francine, AU - Willett,Walter, Y1 - 2017/11/17/ PY - 2017/06/26/received PY - 2017/11/04/accepted PY - 2017/11/18/pubmed PY - 2019/1/29/medline PY - 2017/11/18/entrez KW - Alzheimer’s disease KW - Mediterranean diet KW - Mild cognitive impairment KW - Subjective cognitive decline KW - Subjective cognitive function SP - 223 EP - 234 JF - European journal of epidemiology JO - Eur. J. Epidemiol. VL - 33 IS - 2 N2 - Benefits of a Mediterranean diet for cognition have been suggested, but epidemiologic studies have been relatively small and of limited duration. To prospectively assess the association between long-term adherence to a Mediterranean dietary pattern and self-reported subjective cognitive function (SCF). Prospective observational study. The Health Professionals' Follow-up Study, a prospective cohort of 51,529 men, 40-75 years of age when enrolled in 1986, of whom 27,842 were included in the primary analysis. Mediterranean diet (MD) score, computed from the mean of five food frequency questionnaires, assessed every 4 years from 1986 to 2002. Self-reported SCF assessed by a 6-item questionnaire in 2008 and 2012, and validated by association with genetic variants in apolipoprotein-4. Using the average of 2008 and 2012 SCF scores, 38.0% of men were considered to have moderate memory scores and 7.3% were considered to have poor scores. In a multivariate model, compared with men having a MD score in the lowest quintile, those in the highest quintile had a 36% lower odds of a poor SCF score (odds ratio 0.64, 95% CI 0.55-0.75; P, trend < 0.001) and a 24% lower odds of a moderate SCF score (OR 0.76, 95% CI 0.70-0.83; P, trend < 0.001). Both remote and more recent diet contributed to this relation. Associations were only slightly weaker using baseline dietary data and a lag of 22 years. Long-term adherence to the Mediterranean diet pattern was strongly related to lower subjective cognitive function. These findings provide further evidence that a healthy dietary pattern may prevent or delay cognitive decline. SN - 1573-7284 UR - https://www.unboundmedicine.com/medline/citation/29147948/Adherence_to_Mediterranean_diet_and_subjective_cognitive_function_in_men_ L2 - https://doi.org/10.1007/s10654-017-0330-3 DB - PRIME DP - Unbound Medicine ER -