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Genetic analysis of 29 Y-STR loci in the Chinese Han population from Shanghai.
Forensic Sci Int Genet. 2018 01; 32:e1-e4.FS

Abstract

The analysis of Y chromosomal short tandem repeats (Y-STRs) provides important information that can be used to forensic investigation and population studies. In this study, typing of 29 Y-STRs included in the PowerPlex® Y23 system (PPY23) and Yfiler™ Plus system (Yfiler plus) was performed on 843 unrelated male samples from Han population in Shanghai. Besides null, duplicate, and intermediate alleles reported in previous studies, an allele of 10 at DYS643 with a 2-base deletion in the flanking region was initially observed. The gene diversity (GD) values of the 29 Y-STRs range from 0.4186 at DYS438 to 0.9653 at DYS385a/b. The haplotype diversity of two commonly used haplotype sets, PPY23 set and Yfiler plus set is 0.999980 and 0.999997, respectively. Pairwise genetic distances between Han population in Shanghai and other Han populations estimated using Yfiler plus set are slightly larger than that between other Han populations. Visualization of pairwise genetic distances between 17 worldwide populations using multidimensional scaling (MDS) demonstrates the distribution of populations according to their ethno-geographic patterns. Compared with Yfiler set, Yfiler plus set appears to have a relatively high population discrimination capacity for these tested populations. Altogether, these results can provide useful information of Y-STRs for forensic investigation and population studies.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Department of Forensic Medicine, Shanghai Medical College of Fudan University, Shanghai, 200032, China.

Department of Forensic Medicine, Shanghai Medical College of Fudan University, Shanghai, 200032, China.

Ministry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, 200433, China.

Department of Forensic Medicine, Shanghai Medical College of Fudan University, Shanghai, 200032, China.

Department of Forensic Medicine, Shanghai Medical College of Fudan University, Shanghai, 200032, China.

Department of Forensic Medicine, Shanghai Medical College of Fudan University, Shanghai, 200032, China.

Department of Biochemistry and Molecular Biology, Shanghai Medical College of Fudan University, Shanghai, 200032, China.

Ministry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, 200433, China.

Department of Forensic Medicine, Shanghai Medical College of Fudan University, Shanghai, 200032, China. Electronic address: jhxie@fudan.edu.cn.

MeSH

ChinaChromosomes, Human, YDNA FingerprintingEthnicityGene FrequencyGenetic VariationGenetics, PopulationGenotypeHaplotypesHumansMaleMicrosatellite RepeatsPolymerase Chain Reaction

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29150183

Citation

Zhou, Yuxiang, et al. "Genetic Analysis of 29 Y-STR Loci in the Chinese Han Population From Shanghai." Forensic Science International. Genetics, vol. 32, 2018, pp. e1-e4.

Zhou Y, Shao C, Li L, et al. Genetic analysis of 29 Y-STR loci in the Chinese Han population from Shanghai. Forensic Sci Int Genet. 2018;32:e1-e4.

Zhou, Y., Shao, C., Li, L., Zhang, Y., Liu, B., Yang, Q., Tang, Q., Li, S., & Xie, J. (2018). Genetic analysis of 29 Y-STR loci in the Chinese Han population from Shanghai. Forensic Science International. Genetics, 32, e1-e4. https://doi.org/10.1016/j.fsigen.2017.11.003

Zhou Y, et al. Genetic Analysis of 29 Y-STR Loci in the Chinese Han Population From Shanghai. Forensic Sci Int Genet. 2018;32:e1-e4. PubMed PMID: 29150183.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Genetic analysis of 29 Y-STR loci in the Chinese Han population from Shanghai. AU - Zhou,Yuxiang, AU - Shao,Chengchen, AU - Li,Liming, AU - Zhang,Yaqi, AU - Liu,Baonian, AU - Yang,Qinrui, AU - Tang,Qiqun, AU - Li,Shilin, AU - Xie,Jianhui, Y1 - 2017/11/11/ PY - 2017/06/17/received PY - 2017/09/27/revised PY - 2017/11/09/accepted PY - 2017/11/19/pubmed PY - 2017/12/12/medline PY - 2017/11/19/entrez KW - Forensic genetics KW - Han population KW - PowerPlex(®) Y23 system KW - Y chromosomal short tandem repeats KW - Yfiler™ plus system SP - e1 EP - e4 JF - Forensic science international. Genetics JO - Forensic Sci Int Genet VL - 32 N2 - The analysis of Y chromosomal short tandem repeats (Y-STRs) provides important information that can be used to forensic investigation and population studies. In this study, typing of 29 Y-STRs included in the PowerPlex® Y23 system (PPY23) and Yfiler™ Plus system (Yfiler plus) was performed on 843 unrelated male samples from Han population in Shanghai. Besides null, duplicate, and intermediate alleles reported in previous studies, an allele of 10 at DYS643 with a 2-base deletion in the flanking region was initially observed. The gene diversity (GD) values of the 29 Y-STRs range from 0.4186 at DYS438 to 0.9653 at DYS385a/b. The haplotype diversity of two commonly used haplotype sets, PPY23 set and Yfiler plus set is 0.999980 and 0.999997, respectively. Pairwise genetic distances between Han population in Shanghai and other Han populations estimated using Yfiler plus set are slightly larger than that between other Han populations. Visualization of pairwise genetic distances between 17 worldwide populations using multidimensional scaling (MDS) demonstrates the distribution of populations according to their ethno-geographic patterns. Compared with Yfiler set, Yfiler plus set appears to have a relatively high population discrimination capacity for these tested populations. Altogether, these results can provide useful information of Y-STRs for forensic investigation and population studies. SN - 1878-0326 UR - https://www.unboundmedicine.com/medline/citation/29150183/Genetic_analysis_of_29_Y_STR_loci_in_the_Chinese_Han_population_from_Shanghai_ DB - PRIME DP - Unbound Medicine ER -