Tags

Type your tag names separated by a space and hit enter

Ilex paraguariensis: Potential antioxidant on aluminium toxicity, in an experimental model of Alzheimer's disease.
J Inorg Biochem. 2018 04; 181:104-110.JI

Abstract

Ilex paraguariensis, yerba mate is a native plant from the southern region of Brazil. Studies showed that yerba mate has an antioxidant potential, which could help to reduce the risk of developing neurodegenerative diseases, as Alzheimer's Disease (AD). It's known that I. paraguariensis grows in acid soils with aluminium (Al), which is bioavailable in these soils. Al has a neurotoxic potential related with the progression of neurological disorders. This study aim was to evaluate the potential of I. paraguariensis in the etiology of AD using strains of Caenorhabditis elegans and the concentration of Al and antioxidants in the yerba mate extract. The results of the I. paraguariensis infusions made at 65°C and at 75° C show that there was no significant difference between both temperatures when preparing the tea infusion in relation to the presence of Al, methylxanthines, phenolic compounds and flavonoids. Additionally, in the case of Al, there was no difference between the extracts prepared at both temperatures. The behavioral parameters of C. elegans were altered after a long-term exposure to both factors: I. paraguariensis extract and Al. Through the antioxidant levels results along with the Al content on the Acetylcholinesterase (AChE) activity it is possible to observe that the acute and chronic exposure to Al and I. paraguariensis leaves extract are very similar to wild-type worms. Moreover, we can observe that the results in both the transgenic strains long-term exposed to I. paraguariensis leaves extract and to the Al concentrations presented an increase in the AChE activity.

Authors+Show Affiliations

Federal University of Fronteira Sul, Erechim, RS, Brazil.Federal Institute of Rio Grande do Sul, Sertão, RS, Brazil; Federal University of Fronteira Sul, Erechim, RS, Brazil.Federal Institute of Rio Grande do Sul, Sertão, RS, Brazil.Federal Institute of Rio Grande do Sul, Sertão, RS, Brazil.Federal Institute of Rio Grande do Sul, Sertão, RS, Brazil; Federal University of Fronteira Sul, Erechim, RS, Brazil.Federal University of Fronteira Sul, Erechim, RS, Brazil.Universidade Integrada do Alto Uruguai e Missões - URI, Brazil.Federal University of Fronteira Sul, Erechim, RS, Brazil.Federal University of Fronteira Sul, Erechim, RS, Brazil.Federal Institute of Rio Grande do Sul, Sertão, RS, Brazil; Federal University of Fronteira Sul, Erechim, RS, Brazil. Electronic address: rosikaizer@gmail.com.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29150325

Citation

Bortoli, Pâmela M., et al. "Ilex Paraguariensis: Potential Antioxidant On Aluminium Toxicity, in an Experimental Model of Alzheimer's Disease." Journal of Inorganic Biochemistry, vol. 181, 2018, pp. 104-110.
Bortoli PM, Alves C, Costa E, et al. Ilex paraguariensis: Potential antioxidant on aluminium toxicity, in an experimental model of Alzheimer's disease. J Inorg Biochem. 2018;181:104-110.
Bortoli, P. M., Alves, C., Costa, E., Vanin, A. P., Sofiatti, J. R., Siqueira, D. P., Dallago, R. M., Treichel, H., Vargas, G. D. L. P., & Kaizer, R. R. (2018). Ilex paraguariensis: Potential antioxidant on aluminium toxicity, in an experimental model of Alzheimer's disease. Journal of Inorganic Biochemistry, 181, 104-110. https://doi.org/10.1016/j.jinorgbio.2017.11.001
Bortoli PM, et al. Ilex Paraguariensis: Potential Antioxidant On Aluminium Toxicity, in an Experimental Model of Alzheimer's Disease. J Inorg Biochem. 2018;181:104-110. PubMed PMID: 29150325.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ilex paraguariensis: Potential antioxidant on aluminium toxicity, in an experimental model of Alzheimer's disease. AU - Bortoli,Pâmela M, AU - Alves,Carla, AU - Costa,Eduarda, AU - Vanin,Ana Paula, AU - Sofiatti,Jéssica R, AU - Siqueira,Diego P, AU - Dallago,Rogério M, AU - Treichel,Helen, AU - Vargas,Gean Delise L P, AU - Kaizer,Rosilene R, Y1 - 2017/11/07/ PY - 2017/06/30/received PY - 2017/09/27/revised PY - 2017/11/04/accepted PY - 2017/11/19/pubmed PY - 2018/10/30/medline PY - 2017/11/19/entrez KW - Acetylcholinesterase KW - Antioxidants KW - C. elegans KW - Neurodegeneratives diseases KW - Worms KW - Yerba mate SP - 104 EP - 110 JF - Journal of inorganic biochemistry JO - J Inorg Biochem VL - 181 N2 - Ilex paraguariensis, yerba mate is a native plant from the southern region of Brazil. Studies showed that yerba mate has an antioxidant potential, which could help to reduce the risk of developing neurodegenerative diseases, as Alzheimer's Disease (AD). It's known that I. paraguariensis grows in acid soils with aluminium (Al), which is bioavailable in these soils. Al has a neurotoxic potential related with the progression of neurological disorders. This study aim was to evaluate the potential of I. paraguariensis in the etiology of AD using strains of Caenorhabditis elegans and the concentration of Al and antioxidants in the yerba mate extract. The results of the I. paraguariensis infusions made at 65°C and at 75° C show that there was no significant difference between both temperatures when preparing the tea infusion in relation to the presence of Al, methylxanthines, phenolic compounds and flavonoids. Additionally, in the case of Al, there was no difference between the extracts prepared at both temperatures. The behavioral parameters of C. elegans were altered after a long-term exposure to both factors: I. paraguariensis extract and Al. Through the antioxidant levels results along with the Al content on the Acetylcholinesterase (AChE) activity it is possible to observe that the acute and chronic exposure to Al and I. paraguariensis leaves extract are very similar to wild-type worms. Moreover, we can observe that the results in both the transgenic strains long-term exposed to I. paraguariensis leaves extract and to the Al concentrations presented an increase in the AChE activity. SN - 1873-3344 UR - https://www.unboundmedicine.com/medline/citation/29150325/Ilex_paraguariensis:_Potential_antioxidant_on_aluminium_toxicity_in_an_experimental_model_of_Alzheimer's_disease_ DB - PRIME DP - Unbound Medicine ER -