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Bisphenol S impairs blood functions and induces cardiovascular risks in rats.
Toxicol Rep. 2017; 4:560-565.TR

Abstract

Bisphenol S (BPS) is an industrial chemical which is recently used to replace the potentially toxic Bisphenol A (BPA) in making polycarbonate plastics, epoxy resins and thermal receipt papers. The probable toxic effects of BPS on the functions of haemopoietic and cardiovascular systems have not been reported till to date. We report here that BPS depresses haematological functions and induces cardiovascular risks in rat. Adult male albino rats of Sprague-Dawley strain were given BPS at a dose level of 30, 60 and 120 mg/kg BW/day respectively for 30 days. Red blood cell (RBC) count, white blood cell (WBC) count, Hb concentration, and clotting time have been shown to be significantly (*P < 0.05) reduced in a dose dependent manner in all exposed groups of rats comparing to the control. It has also been shown that BPS increases total serum glucose and protein concentration in the exposed groups of rats. We have observed that BPS increases serum total cholesterol, triglyceride, glycerol free triglyceride, low density lipoprotein (LDL) and very low density lipoprotein (VLDL) concentration, whereas high density lipoprotein (HDL) concentration has been found to be reduced in the exposed groups. BPS significantly increases serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities dose dependently. Moreover, serum calcium, bilirubin and urea concentration have been observed to be increased in all exposed groups. In conclusion, BPS probably impairs the functions of blood and promotes cardiovascular risks in rats.

Authors+Show Affiliations

Molecular Neurotoxicology Laboratory, Department of Physiology, University of Kalyani, Kalyani, West Bengal- 741235, India.Molecular Neurotoxicology Laboratory, Department of Physiology, University of Kalyani, Kalyani, West Bengal- 741235, India.Molecular Neurotoxicology Laboratory, Department of Physiology, University of Kalyani, Kalyani, West Bengal- 741235, India.Molecular Neurotoxicology Laboratory, Department of Physiology, University of Kalyani, Kalyani, West Bengal- 741235, India.Molecular Neurotoxicology Laboratory, Department of Physiology, University of Kalyani, Kalyani, West Bengal- 741235, India.Molecular Neurotoxicology Laboratory, Department of Physiology, University of Kalyani, Kalyani, West Bengal- 741235, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29152460

Citation

Pal, Sanghamitra, et al. "Bisphenol S Impairs Blood Functions and Induces Cardiovascular Risks in Rats." Toxicology Reports, vol. 4, 2017, pp. 560-565.
Pal S, Sarkar K, Nath PP, et al. Bisphenol S impairs blood functions and induces cardiovascular risks in rats. Toxicology reports. 2017;4:560-565.
Pal, S., Sarkar, K., Nath, P. P., Mondal, M., Khatun, A., & Paul, G. (2017). Bisphenol S impairs blood functions and induces cardiovascular risks in rats. Toxicology Reports, 4, 560-565. https://doi.org/10.1016/j.toxrep.2017.10.006
Pal S, et al. Bisphenol S Impairs Blood Functions and Induces Cardiovascular Risks in Rats. Toxicology reports. 2017;4:560-565. PubMed PMID: 29152460.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bisphenol S impairs blood functions and induces cardiovascular risks in rats. AU - Pal,Sanghamitra, AU - Sarkar,Kaushik, AU - Nath,Partha Pratim, AU - Mondal,Mukti, AU - Khatun,Ashma, AU - Paul,Goutam, Y1 - 2017/10/20/ PY - 2017/06/12/received PY - 2017/10/16/revised PY - 2017/10/19/accepted PY - 2017/11/21/entrez PY - 2017/11/21/pubmed PY - 2017/11/21/medline KW - ALT, alanine aminotransferase KW - AST, aspartate aminotransferase KW - BPA, bisphenol A KW - BPS, bisphenol S KW - Bisphenol S KW - Cardiovascular risks KW - Clotting time KW - DMSO, dimethyl sulphoxide KW - HDL cholesterol KW - HDL, high density lipoprotein KW - Hb, hemoglobin KW - LDL cholesterol KW - LDL, low density lipoprotein KW - MCH, mean corpuscular hemoglobin KW - RBC, red blood cells KW - Red blood cell count KW - VLDL, very low density lipoprotein KW - WBC, white blood cells KW - White blood cell count SP - 560 EP - 565 JF - Toxicology reports VL - 4 N2 - Bisphenol S (BPS) is an industrial chemical which is recently used to replace the potentially toxic Bisphenol A (BPA) in making polycarbonate plastics, epoxy resins and thermal receipt papers. The probable toxic effects of BPS on the functions of haemopoietic and cardiovascular systems have not been reported till to date. We report here that BPS depresses haematological functions and induces cardiovascular risks in rat. Adult male albino rats of Sprague-Dawley strain were given BPS at a dose level of 30, 60 and 120 mg/kg BW/day respectively for 30 days. Red blood cell (RBC) count, white blood cell (WBC) count, Hb concentration, and clotting time have been shown to be significantly (*P < 0.05) reduced in a dose dependent manner in all exposed groups of rats comparing to the control. It has also been shown that BPS increases total serum glucose and protein concentration in the exposed groups of rats. We have observed that BPS increases serum total cholesterol, triglyceride, glycerol free triglyceride, low density lipoprotein (LDL) and very low density lipoprotein (VLDL) concentration, whereas high density lipoprotein (HDL) concentration has been found to be reduced in the exposed groups. BPS significantly increases serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities dose dependently. Moreover, serum calcium, bilirubin and urea concentration have been observed to be increased in all exposed groups. In conclusion, BPS probably impairs the functions of blood and promotes cardiovascular risks in rats. SN - 2214-7500 UR - https://www.unboundmedicine.com/medline/citation/29152460/Bisphenol_S_impairs_blood_functions_and_induces_cardiovascular_risks_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2214-7500(17)30073-2 DB - PRIME DP - Unbound Medicine ER -
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