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The effect of viscous soluble fiber on blood pressure: A systematic review and meta-analysis of randomized controlled trials.
Nutr Metab Cardiovasc Dis. 2018 01; 28(1):3-13.NM

Abstract

AIMS

Dietary fiber intake, especially viscous soluble fiber, has been established as a means to reduce cardiometabolic risk factors. Whether this is true for blood pressure remains controversial. A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to investigate the effects of viscous soluble fiber supplementation on blood pressure and quantify the effect of individual fibers.

DATA SYNTHESIS

MEDLINE, Embase, and Cochrane databases were searched. We included RCTs of ≥4-weeks in duration assessing viscous fiber supplementation from five types: β-glucan from oats and barley, guar gum, konjac, pectin and psyllium, on systolic blood pressure (SBP) and diastolic blood pressure (DBP). Study data were pooled using the generic inverse variance method with random effects models and expressed as mean differences (MD) with 95% confidence intervals (CIs). Twenty-two (N = 1430) and twenty-one RCTs (N = 1343) were included in the final analysis for SBP and DBP, respectively. Viscous fiber reduced SBP (MD = -1.59 mmHg [95% CI: -2.72,-0.46]) and DBP (MD = -0.39 mmHg [95% CI: -0.76,-0.01]) at a median dose of 8.7 g/day (1.45-30 g/day) over a median follow-up of 7-weeks. Substantial heterogeneity in SBP (I2 = 72%, P < 0.01) and DBP (I2 = 67%, P < 0.01) analysis occurred. Within the five fiber types, SBP reductions were observed only for supplementation using psyllium fiber (MD = -2.39 mmHg [95% CI: -4.62,-0.17]).

CONCLUSION

Viscous soluble fiber has an overall lowering effect on SBP and DBP. Inclusion of viscous fiber to habitual diets may have additional value in reducing CVD risk via improvement in blood pressure.

PROTOCOL REGISTRATION

ClinicalTrials.gov identifier-NCT02670967.

Authors+Show Affiliations

Clinical Nutrition and Risk Factor Modification Centre, Canada.Clinical Nutrition and Risk Factor Modification Centre, Canada; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada.Clinical Nutrition and Risk Factor Modification Centre, Canada; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada.Clinical Nutrition and Risk Factor Modification Centre, Canada; Department of Pharmacology and Therapeutic, State University of Maringa, Maringa, Brazil.Clinical Nutrition and Risk Factor Modification Centre, Canada; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada.Clinical Nutrition and Risk Factor Modification Centre, Canada; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, St. Michael's Hospital, Toronto, Canada.Clinical Nutrition and Risk Factor Modification Centre, Canada; Keenan Research Center of the Li Ka Shing Knowledge Institute, Canada; Division of Endocrinology & Medicine, Canada; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, St. Michael's Hospital, Toronto, Canada; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada.Clinical Nutrition and Risk Factor Modification Centre, Canada; Keenan Research Center of the Li Ka Shing Knowledge Institute, Canada; Division of Endocrinology & Medicine, Canada; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada. Electronic address: v.vuksan@utoronto.ca.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

29153856

Citation

Khan, K, et al. "The Effect of Viscous Soluble Fiber On Blood Pressure: a Systematic Review and Meta-analysis of Randomized Controlled Trials." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 28, no. 1, 2018, pp. 3-13.
Khan K, Jovanovski E, Ho HVT, et al. The effect of viscous soluble fiber on blood pressure: A systematic review and meta-analysis of randomized controlled trials. Nutr Metab Cardiovasc Dis. 2018;28(1):3-13.
Khan, K., Jovanovski, E., Ho, H. V. T., Marques, A. C. R., Zurbau, A., Mejia, S. B., Sievenpiper, J. L., & Vuksan, V. (2018). The effect of viscous soluble fiber on blood pressure: A systematic review and meta-analysis of randomized controlled trials. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 28(1), 3-13. https://doi.org/10.1016/j.numecd.2017.09.007
Khan K, et al. The Effect of Viscous Soluble Fiber On Blood Pressure: a Systematic Review and Meta-analysis of Randomized Controlled Trials. Nutr Metab Cardiovasc Dis. 2018;28(1):3-13. PubMed PMID: 29153856.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of viscous soluble fiber on blood pressure: A systematic review and meta-analysis of randomized controlled trials. AU - Khan,K, AU - Jovanovski,E, AU - Ho,H V T, AU - Marques,A C R, AU - Zurbau,A, AU - Mejia,S B, AU - Sievenpiper,J L, AU - Vuksan,V, Y1 - 2017/10/07/ PY - 2017/04/06/received PY - 2017/08/25/revised PY - 2017/09/25/accepted PY - 2017/11/21/pubmed PY - 2019/3/15/medline PY - 2017/11/21/entrez KW - Blood pressure KW - Guar gum KW - Konjac KW - Meta-analysis KW - Pectin KW - Psyllium KW - Viscous soluble fiber KW - β-Glucan SP - 3 EP - 13 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 28 IS - 1 N2 - AIMS: Dietary fiber intake, especially viscous soluble fiber, has been established as a means to reduce cardiometabolic risk factors. Whether this is true for blood pressure remains controversial. A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to investigate the effects of viscous soluble fiber supplementation on blood pressure and quantify the effect of individual fibers. DATA SYNTHESIS: MEDLINE, Embase, and Cochrane databases were searched. We included RCTs of ≥4-weeks in duration assessing viscous fiber supplementation from five types: β-glucan from oats and barley, guar gum, konjac, pectin and psyllium, on systolic blood pressure (SBP) and diastolic blood pressure (DBP). Study data were pooled using the generic inverse variance method with random effects models and expressed as mean differences (MD) with 95% confidence intervals (CIs). Twenty-two (N = 1430) and twenty-one RCTs (N = 1343) were included in the final analysis for SBP and DBP, respectively. Viscous fiber reduced SBP (MD = -1.59 mmHg [95% CI: -2.72,-0.46]) and DBP (MD = -0.39 mmHg [95% CI: -0.76,-0.01]) at a median dose of 8.7 g/day (1.45-30 g/day) over a median follow-up of 7-weeks. Substantial heterogeneity in SBP (I2 = 72%, P < 0.01) and DBP (I2 = 67%, P < 0.01) analysis occurred. Within the five fiber types, SBP reductions were observed only for supplementation using psyllium fiber (MD = -2.39 mmHg [95% CI: -4.62,-0.17]). CONCLUSION: Viscous soluble fiber has an overall lowering effect on SBP and DBP. Inclusion of viscous fiber to habitual diets may have additional value in reducing CVD risk via improvement in blood pressure. PROTOCOL REGISTRATION: ClinicalTrials.gov identifier-NCT02670967. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/29153856/The_effect_of_viscous_soluble_fiber_on_blood_pressure:_A_systematic_review_and_meta_analysis_of_randomized_controlled_trials_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(17)30222-3 DB - PRIME DP - Unbound Medicine ER -