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A new topical treatment of atopic dermatitis in pediatric patients based on Ficus carica L. (Fig): A randomized, placebo-controlled clinical trial.
Complement Ther Med. 2017 Dec; 35:85-91.CT

Abstract

BACKGROUND

Atopic dermatitis (AD) is a common, chronic, relapsing and inflammatory skin disease characterized by pruritus and xerosis (dry skin). Its prevalence is on the increase worldwide, particularly in children. As the pathogenesis of AD involves a complex interaction of genetic, environmental and immunological factors, its definitive treatment is difficult.

OBJECTIVE

This clinical trial was designed as equivalence study to investigate the effect of aqueous extract of edible dried fig fruit on the severity of AD as measured with scoring atopic dermatitis (SCORAD), in comparison with Hydrocortisone 1.0% as the routine treatment of AD and base cream as a placebo.

METHOD

Forty five children aged 4 months to 14 years with mild to moderate AD (SCORAD <50) were randomly assigned, in a double blind manner, to three treatment groups in order to perform a randomised, double blinded, placebo-controlled clinical trial. The patients were instructed to apply their allocated creams twice a day for two weeks.

RESULTS

The randomised, placebo-controlled trial indicates that the new treatment had significantly increased efficacy in terms of reducing the SCORAD index, pruritus and intensity scores in comparison with Hydrocortisone 1.0% (p<0.05) and the placebo failed to ameliorate the symptoms.

CONCLUSION

Safety, efficacy, tolerability, and symptom relief were considerable in fig fruit extract in comparison with hydrocortisone 1.0%. This clinical trial suggests that fig fruit extract can be used instead of low potent corticosteroid in mild to moderate cases of AD.

Authors+Show Affiliations

Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Allergy and clinical immunology, Mofid Children's hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Biomedical Engineering, Faculty of Engineering, South Tehran Branch, Islamic Azad University, Tehran, Iran.Firouz Abadi Hospital, Iran University of Medical Sciences, Tehran, Iran.Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Pharmacological Research Center of Medicinal Plants, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: askariv941@mums.ac.ir.Pharmacological Research Center of Medicinal Plants, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: rakhshandehh@mums.ac.ir.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

29154073

Citation

Abbasi, Shirin, et al. "A New Topical Treatment of Atopic Dermatitis in Pediatric Patients Based On Ficus Carica L. (Fig): a Randomized, Placebo-controlled Clinical Trial." Complementary Therapies in Medicine, vol. 35, 2017, pp. 85-91.
Abbasi S, Kamalinejad M, Babaie D, et al. A new topical treatment of atopic dermatitis in pediatric patients based on Ficus carica L. (Fig): A randomized, placebo-controlled clinical trial. Complement Ther Med. 2017;35:85-91.
Abbasi, S., Kamalinejad, M., Babaie, D., Shams, S., Sadr, Z., Gheysari, M., Askari, V. R., & Rakhshandeh, H. (2017). A new topical treatment of atopic dermatitis in pediatric patients based on Ficus carica L. (Fig): A randomized, placebo-controlled clinical trial. Complementary Therapies in Medicine, 35, 85-91. https://doi.org/10.1016/j.ctim.2017.10.003
Abbasi S, et al. A New Topical Treatment of Atopic Dermatitis in Pediatric Patients Based On Ficus Carica L. (Fig): a Randomized, Placebo-controlled Clinical Trial. Complement Ther Med. 2017;35:85-91. PubMed PMID: 29154073.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A new topical treatment of atopic dermatitis in pediatric patients based on Ficus carica L. (Fig): A randomized, placebo-controlled clinical trial. AU - Abbasi,Shirin, AU - Kamalinejad,Mohammad, AU - Babaie,Delara, AU - Shams,SeyedMohammad, AU - Sadr,Zahra, AU - Gheysari,Mehdi, AU - Askari,Vahid Reza, AU - Rakhshandeh,Hassan, Y1 - 2017/10/13/ PY - 2017/05/26/received PY - 2017/08/27/revised PY - 2017/10/09/accepted PY - 2017/11/21/entrez PY - 2017/11/21/pubmed PY - 2018/4/19/medline KW - Atopic dermatitis KW - Ficus carica L. KW - Herbal agents KW - Hydrocortisone 1.0% KW - Scoring atopic dermatitis (SCORAD) SP - 85 EP - 91 JF - Complementary therapies in medicine JO - Complement Ther Med VL - 35 N2 - BACKGROUND: Atopic dermatitis (AD) is a common, chronic, relapsing and inflammatory skin disease characterized by pruritus and xerosis (dry skin). Its prevalence is on the increase worldwide, particularly in children. As the pathogenesis of AD involves a complex interaction of genetic, environmental and immunological factors, its definitive treatment is difficult. OBJECTIVE: This clinical trial was designed as equivalence study to investigate the effect of aqueous extract of edible dried fig fruit on the severity of AD as measured with scoring atopic dermatitis (SCORAD), in comparison with Hydrocortisone 1.0% as the routine treatment of AD and base cream as a placebo. METHOD: Forty five children aged 4 months to 14 years with mild to moderate AD (SCORAD <50) were randomly assigned, in a double blind manner, to three treatment groups in order to perform a randomised, double blinded, placebo-controlled clinical trial. The patients were instructed to apply their allocated creams twice a day for two weeks. RESULTS: The randomised, placebo-controlled trial indicates that the new treatment had significantly increased efficacy in terms of reducing the SCORAD index, pruritus and intensity scores in comparison with Hydrocortisone 1.0% (p<0.05) and the placebo failed to ameliorate the symptoms. CONCLUSION: Safety, efficacy, tolerability, and symptom relief were considerable in fig fruit extract in comparison with hydrocortisone 1.0%. This clinical trial suggests that fig fruit extract can be used instead of low potent corticosteroid in mild to moderate cases of AD. SN - 1873-6963 UR - https://www.unboundmedicine.com/medline/citation/29154073/A_new_topical_treatment_of_atopic_dermatitis_in_pediatric_patients_based_on_Ficus_carica_L___Fig_:_A_randomized_placebo_controlled_clinical_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0965-2299(17)30359-X DB - PRIME DP - Unbound Medicine ER -