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Repeated exposure to sevoflurane impairs the learning and memory of older male rats.
Life Sci. 2018 Jan 01; 192:75-83.LS

Abstract

AIMS

Critically ill old patients sometimes require repeated surgical interventions, and thus it is important to determine the influence of repeated exposure to anesthetics on learning and memory. Sevoflurane, a widely used inhalation anesthetic, has few neurological adverse effects and offers a rapid return to consciousness. But the long-term influence of sevoflurane exposure and the effect of repeated sevoflurane exposure on cognition have rarely been reported, and available studies are contradictory.

MATERIALS AND METHODS

In the present study, the Morris water maze test was employed to investigate the long-term influence of single (4h) or repeated (2h daily for 5 consecutive days) exposure to 1.5% or 2.5% sevoflurane on the learning ability and memory of old (16-18months old) male rats. Testing was performed from 1day to 4weeks after the last exposure. In the hippocampus, brain derived neurotrophic factor (BDNF), NF-κB mRNA, and apoptosis rate were also examined to determine whether cellular biochemical changes related to cognition and memory occurred after single or repeated exposure to sevoflurane.

KEY FINDINGS

Repeated exposure to 2.5% sevoflurane decreased hippocampal levels of BDNF protein, enhanced hippocampal levels of NF-κB mRNA, and increased the apoptosis rate of pyramidal cells. Single exposure to 2.5% sevoflurane, and repeated exposure to either 1.5% or 2.5% sevoflurane significantly compromised learning and memory of old male rats.

SIGNIFICANCE

Repeated exposure to sevoflurane impaired the learning and memory of old male rats, an impairment that was accompanied by cognition-related biochemical changes in the hippocampus.

Authors+Show Affiliations

Department of Pharmacy, Shengjing Hospital of China Medical University, No 36, Sanhao Street, Herping District, Shenyang 110004, China.Department of Anaesthesiology, Shengjing Hospital of China Medical University, No 36, Sanhao Street, Herping District, Shenyang 110004, China.Department of Anaesthesiology, Shengjing Hospital of China Medical University, No 36, Sanhao Street, Herping District, Shenyang 110004, China.Department of Anaesthesiology, Shengjing Hospital of China Medical University, No 36, Sanhao Street, Herping District, Shenyang 110004, China.Department of Anaesthesiology, Shengjing Hospital of China Medical University, No 36, Sanhao Street, Herping District, Shenyang 110004, China.Department of Anaesthesiology, Shengjing Hospital of China Medical University, No 36, Sanhao Street, Herping District, Shenyang 110004, China. Electronic address: tianyue_tougao@yeah.net.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29155302

Citation

Guo, Shanbin, et al. "Repeated Exposure to Sevoflurane Impairs the Learning and Memory of Older Male Rats." Life Sciences, vol. 192, 2018, pp. 75-83.
Guo S, Liu L, Wang C, et al. Repeated exposure to sevoflurane impairs the learning and memory of older male rats. Life Sci. 2018;192:75-83.
Guo, S., Liu, L., Wang, C., Jiang, Q., Dong, Y., & Tian, Y. (2018). Repeated exposure to sevoflurane impairs the learning and memory of older male rats. Life Sciences, 192, 75-83. https://doi.org/10.1016/j.lfs.2017.11.025
Guo S, et al. Repeated Exposure to Sevoflurane Impairs the Learning and Memory of Older Male Rats. Life Sci. 2018 Jan 1;192:75-83. PubMed PMID: 29155302.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Repeated exposure to sevoflurane impairs the learning and memory of older male rats. AU - Guo,Shanbin, AU - Liu,Lidan, AU - Wang,Cong, AU - Jiang,Qian, AU - Dong,Yunxia, AU - Tian,Yue, Y1 - 2017/11/17/ PY - 2017/06/27/received PY - 2017/11/08/revised PY - 2017/11/16/accepted PY - 2017/11/21/pubmed PY - 2018/1/9/medline PY - 2017/11/21/entrez KW - Anesthetics KW - Cognition KW - Hippocampus KW - Neurological adverse effect SP - 75 EP - 83 JF - Life sciences JO - Life Sci. VL - 192 N2 - AIMS: Critically ill old patients sometimes require repeated surgical interventions, and thus it is important to determine the influence of repeated exposure to anesthetics on learning and memory. Sevoflurane, a widely used inhalation anesthetic, has few neurological adverse effects and offers a rapid return to consciousness. But the long-term influence of sevoflurane exposure and the effect of repeated sevoflurane exposure on cognition have rarely been reported, and available studies are contradictory. MATERIALS AND METHODS: In the present study, the Morris water maze test was employed to investigate the long-term influence of single (4h) or repeated (2h daily for 5 consecutive days) exposure to 1.5% or 2.5% sevoflurane on the learning ability and memory of old (16-18months old) male rats. Testing was performed from 1day to 4weeks after the last exposure. In the hippocampus, brain derived neurotrophic factor (BDNF), NF-κB mRNA, and apoptosis rate were also examined to determine whether cellular biochemical changes related to cognition and memory occurred after single or repeated exposure to sevoflurane. KEY FINDINGS: Repeated exposure to 2.5% sevoflurane decreased hippocampal levels of BDNF protein, enhanced hippocampal levels of NF-κB mRNA, and increased the apoptosis rate of pyramidal cells. Single exposure to 2.5% sevoflurane, and repeated exposure to either 1.5% or 2.5% sevoflurane significantly compromised learning and memory of old male rats. SIGNIFICANCE: Repeated exposure to sevoflurane impaired the learning and memory of old male rats, an impairment that was accompanied by cognition-related biochemical changes in the hippocampus. SN - 1879-0631 UR - https://www.unboundmedicine.com/medline/citation/29155302/Repeated_exposure_to_sevoflurane_impairs_the_learning_and_memory_of_older_male_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(17)30602-1 DB - PRIME DP - Unbound Medicine ER -