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Using Retinal Imaging to Study Dementia.
J Vis Exp. 2017 11 06JV

Abstract

The retina offers a unique "window" to study pathophysiological processes of dementia in the brain, as it is an extension of the central nervous system (CNS) and shares prominent similarities with the brain in terms of embryological origin, anatomical features and physiological properties. The vascular and neuronal structure in the retina can now be visualized easily and non-invasively using retinal imaging techniques, including fundus photography and optical coherence tomography (OCT), and quantified semi-automatically using computer-assisted analysis programs. Studying the associations between vascular and neuronal changes in the retina and dementia could improve our understanding of dementia and, potentially, aid in diagnosis and risk assessment. This protocol aims to describe a method of quantifying and analyzing retinal vasculature and neuronal structure, which are potentially associated with dementia. This protocol also provides examples of retinal changes in subjects with dementia, and discusses technical issues and current limitations of retinal imaging.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong.Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong.Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong.Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong.Department of Medicine & Therapeutics, The Chinese University of Hong Kong; Therese Pei Fong Chow Research Centre for Prevention of Dementia, The Chinese University of Hong Kong; Gerald Choa Neuroscience Centre, The Chinese University of Hong Kong.Memory Aging and Cognition Centre, National University Health System; Department of Pharmacology, National University of Singapore.Singapore Eye Research Institute, Singapore National Eye Centre; Duke-NUS Medical School, National University of Singapore.Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong; carolcheung@cuhk.edu.hk.

Pub Type(s)

Journal Article
Video-Audio Media

Language

eng

PubMed ID

29155753

Citation

Chan, Victor T T., et al. "Using Retinal Imaging to Study Dementia." Journal of Visualized Experiments : JoVE, 2017.
Chan VTT, Tso THK, Tang F, et al. Using Retinal Imaging to Study Dementia. J Vis Exp. 2017.
Chan, V. T. T., Tso, T. H. K., Tang, F., Tham, C., Mok, V., Chen, C., Wong, T. Y., & Cheung, C. Y. (2017). Using Retinal Imaging to Study Dementia. Journal of Visualized Experiments : JoVE, (129). https://doi.org/10.3791/56137
Chan VTT, et al. Using Retinal Imaging to Study Dementia. J Vis Exp. 2017 11 6;(129) PubMed PMID: 29155753.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Using Retinal Imaging to Study Dementia. AU - Chan,Victor T T, AU - Tso,Tiffany H K, AU - Tang,Fangyao, AU - Tham,Clement, AU - Mok,Vincent, AU - Chen,Christopher, AU - Wong,Tien Y, AU - Cheung,Carol Y, Y1 - 2017/11/06/ PY - 2017/11/21/entrez PY - 2017/11/21/pubmed PY - 2018/3/30/medline JF - Journal of visualized experiments : JoVE JO - J Vis Exp IS - 129 N2 - The retina offers a unique "window" to study pathophysiological processes of dementia in the brain, as it is an extension of the central nervous system (CNS) and shares prominent similarities with the brain in terms of embryological origin, anatomical features and physiological properties. The vascular and neuronal structure in the retina can now be visualized easily and non-invasively using retinal imaging techniques, including fundus photography and optical coherence tomography (OCT), and quantified semi-automatically using computer-assisted analysis programs. Studying the associations between vascular and neuronal changes in the retina and dementia could improve our understanding of dementia and, potentially, aid in diagnosis and risk assessment. This protocol aims to describe a method of quantifying and analyzing retinal vasculature and neuronal structure, which are potentially associated with dementia. This protocol also provides examples of retinal changes in subjects with dementia, and discusses technical issues and current limitations of retinal imaging. SN - 1940-087X UR - https://www.unboundmedicine.com/medline/citation/29155753/Using_Retinal_Imaging_to_Study_Dementia_ L2 - https://doi.org/10.3791/56137 DB - PRIME DP - Unbound Medicine ER -