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Effect of dietary supplementation with Spirulina platensis on Atrazine-induced oxidative stress- mediated hepatic damage and inflammation in the common carp (Cyprinus carpio L.).
Ecotoxicol Environ Saf. 2018 Mar; 149:135-142.EE

Abstract

The present study evaluated the potential modulatory effect(s) of dietary supplementation with Spirulina platensis (SP) on Atrazine (ATZ)-induced oxidative stress and inflammation in common carp (Cyprinus carpio L.). Common carp was exposed to ATZ (428μg/L) and SP (1%), either alone or in combination, for 40 days. Subsequently, the treatment groups were evaluated for ATZ-induced oxidative stress-mediated hepatic damage and the potential antioxidant effect(s) of SP supplementation. The results indicated that ATZ exposure led to a significant increase in the oxidative stress as suggested by the increased levels of lipid and DNA oxidative damage markers and the significant decline of antioxidant status biomarkers. Further, a real-time PCR analysis of the liver tissues revealed that the ATZ exposure resulted in the significant modulation of the mRNA expression of cytokines involved in the inflammatory response pathway in the liver, such as Interleukin (IL)-1β and IL-10. The expression of IL-1β mRNA was up-regulated while that of IL-10 mRNA was down-regulated. The group subjected to supplementation with SP exhibited a significant decrease in ATZ-induced oxidative stress-mediated hepatotoxic and inflammatory responses; however, these did not attain the levels of the control group. Owing to its ability for protecting against ATZ-induced oxidative stress-mediated hepatic damage in carps, SP could be a potentially effective and promising candidate as a feed additive for carps in aquaculture.

Authors+Show Affiliations

Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine-Qena, South Vally University, Egypt.Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Zagazig University, 44511 Zagazig, Egypt. Electronic address: dr_samahkhalil@yahoo.com.Department of Pharmacology, Faculty of Veterinary Medicine, Qena, South Vally University, Egypt.Department of Animal Wealth Development, Faculty of Veterinary Medicine, Zagazig University, Egypt.Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine-Qena, South Vally University, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29156305

Citation

Toughan, Hosam, et al. "Effect of Dietary Supplementation With Spirulina Platensis On Atrazine-induced Oxidative Stress- Mediated Hepatic Damage and Inflammation in the Common Carp (Cyprinus Carpio L.)." Ecotoxicology and Environmental Safety, vol. 149, 2018, pp. 135-142.
Toughan H, Khalil SR, El-Ghoneimy AA, et al. Effect of dietary supplementation with Spirulina platensis on Atrazine-induced oxidative stress- mediated hepatic damage and inflammation in the common carp (Cyprinus carpio L.). Ecotoxicol Environ Saf. 2018;149:135-142.
Toughan, H., Khalil, S. R., El-Ghoneimy, A. A., Awad, A., & Seddek, A. S. (2018). Effect of dietary supplementation with Spirulina platensis on Atrazine-induced oxidative stress- mediated hepatic damage and inflammation in the common carp (Cyprinus carpio L.). Ecotoxicology and Environmental Safety, 149, 135-142. https://doi.org/10.1016/j.ecoenv.2017.11.018
Toughan H, et al. Effect of Dietary Supplementation With Spirulina Platensis On Atrazine-induced Oxidative Stress- Mediated Hepatic Damage and Inflammation in the Common Carp (Cyprinus Carpio L.). Ecotoxicol Environ Saf. 2018;149:135-142. PubMed PMID: 29156305.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of dietary supplementation with Spirulina platensis on Atrazine-induced oxidative stress- mediated hepatic damage and inflammation in the common carp (Cyprinus carpio L.). AU - Toughan,Hosam, AU - Khalil,Samah R, AU - El-Ghoneimy,Ashraf Ahmed, AU - Awad,Ashraf, AU - Seddek,A Sh, Y1 - 2017/11/20/ PY - 2017/10/12/received PY - 2017/11/01/revised PY - 2017/11/09/accepted PY - 2017/11/21/pubmed PY - 2018/5/16/medline PY - 2017/11/21/entrez KW - Atrazine KW - Cyprinus carpio KW - DNA damage KW - Interleukin −1β KW - Spirulina platensis SP - 135 EP - 142 JF - Ecotoxicology and environmental safety JO - Ecotoxicol Environ Saf VL - 149 N2 - The present study evaluated the potential modulatory effect(s) of dietary supplementation with Spirulina platensis (SP) on Atrazine (ATZ)-induced oxidative stress and inflammation in common carp (Cyprinus carpio L.). Common carp was exposed to ATZ (428μg/L) and SP (1%), either alone or in combination, for 40 days. Subsequently, the treatment groups were evaluated for ATZ-induced oxidative stress-mediated hepatic damage and the potential antioxidant effect(s) of SP supplementation. The results indicated that ATZ exposure led to a significant increase in the oxidative stress as suggested by the increased levels of lipid and DNA oxidative damage markers and the significant decline of antioxidant status biomarkers. Further, a real-time PCR analysis of the liver tissues revealed that the ATZ exposure resulted in the significant modulation of the mRNA expression of cytokines involved in the inflammatory response pathway in the liver, such as Interleukin (IL)-1β and IL-10. The expression of IL-1β mRNA was up-regulated while that of IL-10 mRNA was down-regulated. The group subjected to supplementation with SP exhibited a significant decrease in ATZ-induced oxidative stress-mediated hepatotoxic and inflammatory responses; however, these did not attain the levels of the control group. Owing to its ability for protecting against ATZ-induced oxidative stress-mediated hepatic damage in carps, SP could be a potentially effective and promising candidate as a feed additive for carps in aquaculture. SN - 1090-2414 UR - https://www.unboundmedicine.com/medline/citation/29156305/Effect_of_dietary_supplementation_with_Spirulina_platensis_on_Atrazine_induced_oxidative_stress__mediated_hepatic_damage_and_inflammation_in_the_common_carp__Cyprinus_carpio_L___ DB - PRIME DP - Unbound Medicine ER -