Tags

Type your tag names separated by a space and hit enter

Modulatory effects of green tea extract against the hepatotoxic effects of 4-nonylphenol in catfish (Clarias gariepinus).
Ecotoxicol Environ Saf. 2018 Mar; 149:159-165.EE

Abstract

The antioxidant role of the green tea (Camellia sinensis) extract (GTE) was examined to remedy the toxic effects of (0.2mgl-1) 4-nonylphenol(4-NP). Biochemical parameters, antioxidant enzymes, liver lipid peroxidation (LPO), DNA fragmentation, and apoptosis as well as histopathology of liver of African catfish Clarias gariepinus were considered. Catfishes were divided into four groups: first group (control), second group (0.2mgl-1 of 4-NP), third group (0.2mgl-1of 4-NP +100mg GTE l-1water), and fourth group (0.2mgl-1 of 4-NP +200mg GTE l-1water). The results showed that significant increments of serum glucose, AST, ALT, total protein, total lipids, cholesterol, G6PDH, and cortisol. Meanwhile, serum acetylcholinesterase, ALP, and LDH were significantly reduced. In addition, antioxidant enzymes (SOD, CAT, GST, and TAC) levels were reduced in 4-NP treated fish compared to control. Also, there were significant increments in hepatic LPO, DNA fragmentation, and apoptotic erythrocytes in 4-NP treated fish compared to control. Liver of 4-NP treated fish showed some histopathological alterations such as, vacuolization in hepatocytes, congestion in central vein, infiltration of mononuclear inflammatory cells, and necrosis as well as depletion of glycogen content of liver. Addition of green tea extract into the water restored the alterations in most of those biomarkers induced by 4-NP. We concluded that, GTE has a protective role against hepatic failure, depletion of antioxidant defense, and genotoxicity induced 4-NP in C. gariepinus.

Authors+Show Affiliations

Zoology Department, Faculty of Science, Assiut University, 71516 Assiut, Egypt. Electronic address: alaasayed@aun.edu.eg.Zoology Department, Faculty of Science, Sohag University, 8562 Sohag, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29156308

Citation

Sayed, Alaa El-Din H., and Hamdy A M. Soliman. "Modulatory Effects of Green Tea Extract Against the Hepatotoxic Effects of 4-nonylphenol in Catfish (Clarias Gariepinus)." Ecotoxicology and Environmental Safety, vol. 149, 2018, pp. 159-165.
Sayed AEH, Soliman HAM. Modulatory effects of green tea extract against the hepatotoxic effects of 4-nonylphenol in catfish (Clarias gariepinus). Ecotoxicol Environ Saf. 2018;149:159-165.
Sayed, A. E. H., & Soliman, H. A. M. (2018). Modulatory effects of green tea extract against the hepatotoxic effects of 4-nonylphenol in catfish (Clarias gariepinus). Ecotoxicology and Environmental Safety, 149, 159-165. https://doi.org/10.1016/j.ecoenv.2017.11.007
Sayed AEH, Soliman HAM. Modulatory Effects of Green Tea Extract Against the Hepatotoxic Effects of 4-nonylphenol in Catfish (Clarias Gariepinus). Ecotoxicol Environ Saf. 2018;149:159-165. PubMed PMID: 29156308.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulatory effects of green tea extract against the hepatotoxic effects of 4-nonylphenol in catfish (Clarias gariepinus). AU - Sayed,Alaa El-Din H, AU - Soliman,Hamdy A M, Y1 - 2017/12/19/ PY - 2017/09/25/received PY - 2017/10/30/revised PY - 2017/11/03/accepted PY - 2017/11/21/pubmed PY - 2018/5/16/medline PY - 2017/11/21/entrez KW - 4-Nonylphenol KW - GTE KW - Genotoxicity KW - Histopathological KW - Oxidative damage SP - 159 EP - 165 JF - Ecotoxicology and environmental safety JO - Ecotoxicol Environ Saf VL - 149 N2 - The antioxidant role of the green tea (Camellia sinensis) extract (GTE) was examined to remedy the toxic effects of (0.2mgl-1) 4-nonylphenol(4-NP). Biochemical parameters, antioxidant enzymes, liver lipid peroxidation (LPO), DNA fragmentation, and apoptosis as well as histopathology of liver of African catfish Clarias gariepinus were considered. Catfishes were divided into four groups: first group (control), second group (0.2mgl-1 of 4-NP), third group (0.2mgl-1of 4-NP +100mg GTE l-1water), and fourth group (0.2mgl-1 of 4-NP +200mg GTE l-1water). The results showed that significant increments of serum glucose, AST, ALT, total protein, total lipids, cholesterol, G6PDH, and cortisol. Meanwhile, serum acetylcholinesterase, ALP, and LDH were significantly reduced. In addition, antioxidant enzymes (SOD, CAT, GST, and TAC) levels were reduced in 4-NP treated fish compared to control. Also, there were significant increments in hepatic LPO, DNA fragmentation, and apoptotic erythrocytes in 4-NP treated fish compared to control. Liver of 4-NP treated fish showed some histopathological alterations such as, vacuolization in hepatocytes, congestion in central vein, infiltration of mononuclear inflammatory cells, and necrosis as well as depletion of glycogen content of liver. Addition of green tea extract into the water restored the alterations in most of those biomarkers induced by 4-NP. We concluded that, GTE has a protective role against hepatic failure, depletion of antioxidant defense, and genotoxicity induced 4-NP in C. gariepinus. SN - 1090-2414 UR - https://www.unboundmedicine.com/medline/citation/29156308/Modulatory_effects_of_green_tea_extract_against_the_hepatotoxic_effects_of_4_nonylphenol_in_catfish__Clarias_gariepinus__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0147-6513(17)30758-3 DB - PRIME DP - Unbound Medicine ER -