Tags

Type your tag names separated by a space and hit enter

The role of hydrogen sulfide in cyclic nucleotide signaling.
Biochem Pharmacol. 2018 03; 149:20-28.BP

Abstract

Hydrogen sulfide (H2S) is recognized as an endogenous gaseous transmitter alongside nitric oxide (NO) and carbon monoxide (CO). By integrating into multiple signaling pathways, H2S elicits biological functions in various mammalian systems. Among these pathways, cyclic nucleotide signaling has gradually gained attention in the past decade. Based on current evidence, it seems that H2S may differentially affect the activity of resting adenylyl cyclases (ACs) and activated ACs, therefore playing a dual role in the regulation of cyclic adenosine monophosphate (cAMP) mediated signaling. However, how H2S achieves the differential regulation on ACs remains unknown at molecular level. In the context of cyclic guanosine monophosphate (cGMP) regulation, H2S augments its downstream signaling at least through three different mechanisms: (1) H2S potentiates the response of soluble guanylyl cyclases (sGCs) to NO; (2) H2S inhibits activity of phosphodiesterases (PDEs); and (3) H2S enhances the production of NO. By regulating cyclic nucleotide signaling, H2S possesses therapeutic potentials particularly for hypertension and cardiac injury which have also been discussed in the current review. Nevertheless, a detailed portrayal of H2S mediated interaction with target proteins is still required for a better understanding of the role of this important gaseous mediator in regulating cyclic nucleotide signaling.

Authors+Show Affiliations

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore.Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore; Life Science Institute, National University of Singapore, Singapore.Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore.Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore.Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore.Life Science Institute, National University of Singapore, Singapore. Electronic address: phcbjs@nus.edu.sg.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

29158149

Citation

Cao, Xu, et al. "The Role of Hydrogen Sulfide in Cyclic Nucleotide Signaling." Biochemical Pharmacology, vol. 149, 2018, pp. 20-28.
Cao X, Wu Z, Xiong S, et al. The role of hydrogen sulfide in cyclic nucleotide signaling. Biochem Pharmacol. 2018;149:20-28.
Cao, X., Wu, Z., Xiong, S., Cao, L., Sethi, G., & Bian, J. S. (2018). The role of hydrogen sulfide in cyclic nucleotide signaling. Biochemical Pharmacology, 149, 20-28. https://doi.org/10.1016/j.bcp.2017.11.011
Cao X, et al. The Role of Hydrogen Sulfide in Cyclic Nucleotide Signaling. Biochem Pharmacol. 2018;149:20-28. PubMed PMID: 29158149.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of hydrogen sulfide in cyclic nucleotide signaling. AU - Cao,Xu, AU - Wu,Zhiyuan, AU - Xiong,Siping, AU - Cao,Lei, AU - Sethi,Gautam, AU - Bian,Jin-Song, Y1 - 2017/11/20/ PY - 2017/09/15/received PY - 2017/11/16/accepted PY - 2017/11/22/pubmed PY - 2018/12/12/medline PY - 2017/11/22/entrez KW - Cardioprotection KW - Cyclic nucleotide KW - Hydrogen sulfide KW - Hypertension KW - Phosphodiesterase KW - cAMP KW - cGMP SP - 20 EP - 28 JF - Biochemical pharmacology JO - Biochem Pharmacol VL - 149 N2 - Hydrogen sulfide (H2S) is recognized as an endogenous gaseous transmitter alongside nitric oxide (NO) and carbon monoxide (CO). By integrating into multiple signaling pathways, H2S elicits biological functions in various mammalian systems. Among these pathways, cyclic nucleotide signaling has gradually gained attention in the past decade. Based on current evidence, it seems that H2S may differentially affect the activity of resting adenylyl cyclases (ACs) and activated ACs, therefore playing a dual role in the regulation of cyclic adenosine monophosphate (cAMP) mediated signaling. However, how H2S achieves the differential regulation on ACs remains unknown at molecular level. In the context of cyclic guanosine monophosphate (cGMP) regulation, H2S augments its downstream signaling at least through three different mechanisms: (1) H2S potentiates the response of soluble guanylyl cyclases (sGCs) to NO; (2) H2S inhibits activity of phosphodiesterases (PDEs); and (3) H2S enhances the production of NO. By regulating cyclic nucleotide signaling, H2S possesses therapeutic potentials particularly for hypertension and cardiac injury which have also been discussed in the current review. Nevertheless, a detailed portrayal of H2S mediated interaction with target proteins is still required for a better understanding of the role of this important gaseous mediator in regulating cyclic nucleotide signaling. SN - 1873-2968 UR - https://www.unboundmedicine.com/medline/citation/29158149/The_role_of_hydrogen_sulfide_in_cyclic_nucleotide_signaling_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-2952(17)30692-5 DB - PRIME DP - Unbound Medicine ER -