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Role for extracellular vesicles in the tumour microenvironment.

Abstract

Extracellular vesicles (EVs) are small-membrane vesicles secreted by most cells types with the role to provide intercellular communication both locally and systemically. The transfer of their content between cells, which includes nucleic acids, proteins and lipids, confers the means for these interactions and induces significant cellular behaviour changes in the receiving cell. EVs are implicated in the regulation of numerous physiological and pathological processes, including development and neurological and cardiovascular diseases. Importantly, it has been shown that EV signalling is essential in almost all the steps necessary for the progress of carcinomas, from primary tumours to metastasis. In this review, we will focus on the latest findings for EV biology in relation to cancer progression and the tumour microenvironment.This article is part of the discussion meeting issue 'Extracellular vesicles and the tumour microenvironment'.

Authors+Show Affiliations

Epigenetics and Cellular Senescence Group, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK a.ologhlen@qmul.ac.uk.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29158316

Citation

O'Loghlen, Ana. "Role for Extracellular Vesicles in the Tumour Microenvironment." Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, vol. 373, no. 1737, 2018.
O'Loghlen A. Role for extracellular vesicles in the tumour microenvironment. Philos Trans R Soc Lond, B, Biol Sci. 2018;373(1737).
O'Loghlen, A. (2018). Role for extracellular vesicles in the tumour microenvironment. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 373(1737), doi:10.1098/rstb.2016.0488.
O'Loghlen A. Role for Extracellular Vesicles in the Tumour Microenvironment. Philos Trans R Soc Lond, B, Biol Sci. 2018 Jan 5;373(1737) PubMed PMID: 29158316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role for extracellular vesicles in the tumour microenvironment. A1 - O'Loghlen,Ana, PY - 2017/04/15/accepted PY - 2017/11/22/entrez PY - 2017/11/22/pubmed PY - 2018/6/15/medline KW - EV KW - cancer KW - extracellular vesicles KW - intercellular communication KW - microenvironment JF - Philosophical transactions of the Royal Society of London. Series B, Biological sciences JO - Philos. Trans. R. Soc. Lond., B, Biol. Sci. VL - 373 IS - 1737 N2 - Extracellular vesicles (EVs) are small-membrane vesicles secreted by most cells types with the role to provide intercellular communication both locally and systemically. The transfer of their content between cells, which includes nucleic acids, proteins and lipids, confers the means for these interactions and induces significant cellular behaviour changes in the receiving cell. EVs are implicated in the regulation of numerous physiological and pathological processes, including development and neurological and cardiovascular diseases. Importantly, it has been shown that EV signalling is essential in almost all the steps necessary for the progress of carcinomas, from primary tumours to metastasis. In this review, we will focus on the latest findings for EV biology in relation to cancer progression and the tumour microenvironment.This article is part of the discussion meeting issue 'Extracellular vesicles and the tumour microenvironment'. SN - 1471-2970 UR - https://www.unboundmedicine.com/medline/citation/29158316/Role_for_extracellular_vesicles_in_the_tumour_microenvironment_ L2 - https://royalsocietypublishing.org/doi/full/10.1098/rstb.2016.0488?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -