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Low fermentable oligo-di-mono-saccharides and polyols diet versus general dietary advice in patients with diarrhea-predominant irritable bowel syndrome: A randomized controlled trial.
J Gastroenterol Hepatol. 2018 Jun; 33(6):1192-1199.JG

Abstract

BACKGROUND AND AIM

Recent evidence indicates that new approach of the diet with low fermentable oligo-di-mono-saccharides and polyols (FODMAPs) may have an effective role in management of the patients with irritable bowel syndrome (IBS). We compared the results of low FODMAP diet with current dietary treatment, general dietary advices (GDA), on the clinical response in patients with diarrhea subtype of IBS (IBS-D).

METHODS

In this randomized, controlled, single-blind trial, we included 110 patients with IBS-D in two intervention groups. Participants were randomly assigned to the low FODMAP diet (n = 55) and GDA (n = 55) for 6 weeks after a 10-day screening period. Gastrointestinal symptoms and bowel habit status were evaluated using a symptom severity scoring system and Bristol stool form scale pre-intervention and post-intervention. Patients completed 3-day food diary before and after the intervention.

RESULTS

Of 110 patients, 101 completed the dietary interventions. At the baseline, the nutrient intake, severity of symptoms, and demographic data were similar between two groups. After 6 weeks, the low FODMAP diet improves significantly overall gastrointestinal symptoms scores, stool frequency, and consistency versus GDA group (P < 0.001, P < 0.001, and P = 0.003, respectively). Compared with the baseline, both intervention groups expressed a significant reduction in overall scores of symptom severity scoring system, abdominal pain, distension, consistency, and frequency, but this reduction is greater in low FODMAP diet group.

CONCLUSIONS

Both low FODMAP diet and GDA in patients with IBS-D led to adequate improvement of gastrointestinal symptoms for 6 weeks. However, the low FODMAP diet has greater benefits in IBS improvement.

Authors+Show Affiliations

Gastroenterology and Hepatology Research Center, Kerman University of Medical Sciences, Kerman, Iran.Gastroenterology and Hepatology Research Center, Kerman University of Medical Sciences, Kerman, Iran.Gastroenterology and Hepatology Research Center, Kerman University of Medical Sciences, Kerman, Iran.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

29159993

Citation

Zahedi, Mohammad Javad, et al. "Low Fermentable Oligo-di-mono-saccharides and Polyols Diet Versus General Dietary Advice in Patients With Diarrhea-predominant Irritable Bowel Syndrome: a Randomized Controlled Trial." Journal of Gastroenterology and Hepatology, vol. 33, no. 6, 2018, pp. 1192-1199.
Zahedi MJ, Behrouz V, Azimi M. Low fermentable oligo-di-mono-saccharides and polyols diet versus general dietary advice in patients with diarrhea-predominant irritable bowel syndrome: A randomized controlled trial. J Gastroenterol Hepatol. 2018;33(6):1192-1199.
Zahedi, M. J., Behrouz, V., & Azimi, M. (2018). Low fermentable oligo-di-mono-saccharides and polyols diet versus general dietary advice in patients with diarrhea-predominant irritable bowel syndrome: A randomized controlled trial. Journal of Gastroenterology and Hepatology, 33(6), 1192-1199. https://doi.org/10.1111/jgh.14051
Zahedi MJ, Behrouz V, Azimi M. Low Fermentable Oligo-di-mono-saccharides and Polyols Diet Versus General Dietary Advice in Patients With Diarrhea-predominant Irritable Bowel Syndrome: a Randomized Controlled Trial. J Gastroenterol Hepatol. 2018;33(6):1192-1199. PubMed PMID: 29159993.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low fermentable oligo-di-mono-saccharides and polyols diet versus general dietary advice in patients with diarrhea-predominant irritable bowel syndrome: A randomized controlled trial. AU - Zahedi,Mohammad Javad, AU - Behrouz,Vahideh, AU - Azimi,Maryam, Y1 - 2018/02/21/ PY - 2017/10/06/received PY - 2017/10/30/revised PY - 2017/11/11/accepted PY - 2017/11/22/pubmed PY - 2018/8/21/medline PY - 2017/11/22/entrez KW - abdominal pain KW - carbohydrates KW - irritable bowel syndrome KW - low FODMAP diet SP - 1192 EP - 1199 JF - Journal of gastroenterology and hepatology JO - J. Gastroenterol. Hepatol. VL - 33 IS - 6 N2 - BACKGROUND AND AIM: Recent evidence indicates that new approach of the diet with low fermentable oligo-di-mono-saccharides and polyols (FODMAPs) may have an effective role in management of the patients with irritable bowel syndrome (IBS). We compared the results of low FODMAP diet with current dietary treatment, general dietary advices (GDA), on the clinical response in patients with diarrhea subtype of IBS (IBS-D). METHODS: In this randomized, controlled, single-blind trial, we included 110 patients with IBS-D in two intervention groups. Participants were randomly assigned to the low FODMAP diet (n = 55) and GDA (n = 55) for 6 weeks after a 10-day screening period. Gastrointestinal symptoms and bowel habit status were evaluated using a symptom severity scoring system and Bristol stool form scale pre-intervention and post-intervention. Patients completed 3-day food diary before and after the intervention. RESULTS: Of 110 patients, 101 completed the dietary interventions. At the baseline, the nutrient intake, severity of symptoms, and demographic data were similar between two groups. After 6 weeks, the low FODMAP diet improves significantly overall gastrointestinal symptoms scores, stool frequency, and consistency versus GDA group (P < 0.001, P < 0.001, and P = 0.003, respectively). Compared with the baseline, both intervention groups expressed a significant reduction in overall scores of symptom severity scoring system, abdominal pain, distension, consistency, and frequency, but this reduction is greater in low FODMAP diet group. CONCLUSIONS: Both low FODMAP diet and GDA in patients with IBS-D led to adequate improvement of gastrointestinal symptoms for 6 weeks. However, the low FODMAP diet has greater benefits in IBS improvement. SN - 1440-1746 UR - https://www.unboundmedicine.com/medline/citation/29159993/Low_fermentable_oligo_di_mono_saccharides_and_polyols_diet_versus_general_dietary_advice_in_patients_with_diarrhea_predominant_irritable_bowel_syndrome:_A_randomized_controlled_trial_ L2 - https://doi.org/10.1111/jgh.14051 DB - PRIME DP - Unbound Medicine ER -