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Selective Voltage-Gated Sodium Channel Peptide Toxins from Animal Venom: Pharmacological Probes and Analgesic Drug Development.
ACS Chem Neurosci. 2018 02 21; 9(2):187-197.AC

Abstract

Voltage-gated sodium channels (Navs) play critical roles in action potential generation and propagation. Nav channelopathy as well as pathological sensitization contribute to allodynia and hyperalgesia. Recent evidence has demonstrated the significant roles of Nav subtypes (Nav1.3, 1.7, 1.8, and 1.9) in nociceptive transduction, and therefore these Navs may represent attractive targets for analgesic drug discovery. Animal toxins are structurally diverse peptides that are highly potent yet selective on ion channel subtypes and therefore represent valuable probes to elucidate the structures, gating properties, and cellular functions of ion channels. In this review, we summarize recent advances on peptide toxins from animal venom that selectively target Nav1.3, 1.7, 1.8, and 1.9, along with their potential in analgesic drug discovery.

Authors+Show Affiliations

Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, China Pharmaceutical University , Nanjing 211198, China.Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, China Pharmaceutical University , Nanjing 211198, China.Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, China Pharmaceutical University , Nanjing 211198, China.Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, China Pharmaceutical University , Nanjing 211198, China.Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, China Pharmaceutical University , Nanjing 211198, China.Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, China Pharmaceutical University , Nanjing 211198, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

29161016

Citation

Wu, Ying, et al. "Selective Voltage-Gated Sodium Channel Peptide Toxins From Animal Venom: Pharmacological Probes and Analgesic Drug Development." ACS Chemical Neuroscience, vol. 9, no. 2, 2018, pp. 187-197.
Wu Y, Ma H, Zhang F, et al. Selective Voltage-Gated Sodium Channel Peptide Toxins from Animal Venom: Pharmacological Probes and Analgesic Drug Development. ACS Chem Neurosci. 2018;9(2):187-197.
Wu, Y., Ma, H., Zhang, F., Zhang, C., Zou, X., & Cao, Z. (2018). Selective Voltage-Gated Sodium Channel Peptide Toxins from Animal Venom: Pharmacological Probes and Analgesic Drug Development. ACS Chemical Neuroscience, 9(2), 187-197. https://doi.org/10.1021/acschemneuro.7b00406
Wu Y, et al. Selective Voltage-Gated Sodium Channel Peptide Toxins From Animal Venom: Pharmacological Probes and Analgesic Drug Development. ACS Chem Neurosci. 2018 02 21;9(2):187-197. PubMed PMID: 29161016.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selective Voltage-Gated Sodium Channel Peptide Toxins from Animal Venom: Pharmacological Probes and Analgesic Drug Development. AU - Wu,Ying, AU - Ma,Hui, AU - Zhang,Fan, AU - Zhang,Chunlei, AU - Zou,Xiaohan, AU - Cao,Zhengyu, Y1 - 2017/12/08/ PY - 2017/11/22/pubmed PY - 2018/8/18/medline PY - 2017/11/22/entrez KW - Voltage-gated sodium channels KW - animal toxins KW - pain KW - peptide therapeutic SP - 187 EP - 197 JF - ACS chemical neuroscience JO - ACS Chem Neurosci VL - 9 IS - 2 N2 - Voltage-gated sodium channels (Navs) play critical roles in action potential generation and propagation. Nav channelopathy as well as pathological sensitization contribute to allodynia and hyperalgesia. Recent evidence has demonstrated the significant roles of Nav subtypes (Nav1.3, 1.7, 1.8, and 1.9) in nociceptive transduction, and therefore these Navs may represent attractive targets for analgesic drug discovery. Animal toxins are structurally diverse peptides that are highly potent yet selective on ion channel subtypes and therefore represent valuable probes to elucidate the structures, gating properties, and cellular functions of ion channels. In this review, we summarize recent advances on peptide toxins from animal venom that selectively target Nav1.3, 1.7, 1.8, and 1.9, along with their potential in analgesic drug discovery. SN - 1948-7193 UR - https://www.unboundmedicine.com/medline/citation/29161016/Selective_Voltage_Gated_Sodium_Channel_Peptide_Toxins_from_Animal_Venom:_Pharmacological_Probes_and_Analgesic_Drug_Development_ L2 - https://dx.doi.org/10.1021/acschemneuro.7b00406 DB - PRIME DP - Unbound Medicine ER -