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Obesity Impairs the Adaptive Immune Response to Influenza Virus.
Ann Am Thorac Soc. 2017 Nov; 14(Supplement_5):S406-S409.AA

Abstract

Influenza, a highly contagious respiratory tract infection, affects millions of adults and children each year. Several high-risk populations include children, the elderly, the immunocompromised, and recently the obese. Given the dramatic rise in obesity over the past few decades, this increased risk for influenza infection poses a serious public health threat because nearly 500 million adults and children worldwide are classified as obese. Obesity impairs the immune response to influenza and influenza vaccination through alterations of the cellular immune system. Compared with vaccinated healthy-weight adults, vaccinated obese adults have twice the risk of influenza or influenza-like illness despite equal serological response to vaccination. This challenges the current standard of protection for influenza and suggests that further vaccination methods or therapeutics are required to combat this virulent respiratory virus.

Authors+Show Affiliations

Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29161078

Citation

Green, William D., and Melinda A. Beck. "Obesity Impairs the Adaptive Immune Response to Influenza Virus." Annals of the American Thoracic Society, vol. 14, no. Supplement_5, 2017, pp. S406-S409.
Green WD, Beck MA. Obesity Impairs the Adaptive Immune Response to Influenza Virus. Ann Am Thorac Soc. 2017;14(Supplement_5):S406-S409.
Green, W. D., & Beck, M. A. (2017). Obesity Impairs the Adaptive Immune Response to Influenza Virus. Annals of the American Thoracic Society, 14(Supplement_5), S406-S409. https://doi.org/10.1513/AnnalsATS.201706-447AW
Green WD, Beck MA. Obesity Impairs the Adaptive Immune Response to Influenza Virus. Ann Am Thorac Soc. 2017;14(Supplement_5):S406-S409. PubMed PMID: 29161078.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Obesity Impairs the Adaptive Immune Response to Influenza Virus. AU - Green,William D, AU - Beck,Melinda A, PY - 2017/11/22/entrez PY - 2017/11/22/pubmed PY - 2018/7/25/medline KW - immunity KW - influenza KW - obesity KW - vaccination SP - S406 EP - S409 JF - Annals of the American Thoracic Society JO - Ann Am Thorac Soc VL - 14 IS - Supplement_5 N2 - Influenza, a highly contagious respiratory tract infection, affects millions of adults and children each year. Several high-risk populations include children, the elderly, the immunocompromised, and recently the obese. Given the dramatic rise in obesity over the past few decades, this increased risk for influenza infection poses a serious public health threat because nearly 500 million adults and children worldwide are classified as obese. Obesity impairs the immune response to influenza and influenza vaccination through alterations of the cellular immune system. Compared with vaccinated healthy-weight adults, vaccinated obese adults have twice the risk of influenza or influenza-like illness despite equal serological response to vaccination. This challenges the current standard of protection for influenza and suggests that further vaccination methods or therapeutics are required to combat this virulent respiratory virus. SN - 2325-6621 UR - https://www.unboundmedicine.com/medline/citation/29161078/full_citation L2 - https://www.atsjournals.org/doi/10.1513/AnnalsATS.201706-447AW?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -