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Infant HPA axis as a potential mechanism linking maternal mental health and infant telomere length.
Psychoneuroendocrinology. 2018 02; 88:38-46.P

Abstract

Maternal depression has been suggested to be an independent risk factor for both dysregulated hypothalamic-pituitary-adrenal axis (HPA) functioning and shorter telomere length in offspring. In contrast, research suggests that individual differences in mindfulness may act as a protective factor against one's own telomere degradation. Currently, research has yet to investigate the association between longitudinal changes in maternal mental health (depressive symptoms and mindfulness) and salivary infant telomere length, and whether such changes might be mediated by alterations in infant cortisol response. In 48 mother-infant dyads, we investigated whether the changes in maternal mental health, when infants were 6-12 months of age, predicted change in infant cortisol reactivity and recovery over this period. We also investigated whether these changes in infant HPA functioning predicted subsequent infant salivary telomere length at 18 months of age. Furthermore, we investigated whether change in infant HPA functioning provided a potential pathway between changes in maternal mental health factors and infant salivary telomere length. Analyses revealed that increases in maternal depressive symptoms over that six-month period indirectly related to subsequent shorter infant telomere length through increased infant cortisol reactivity. Implications for the ways in which maternal mental health can impact offspring stress mechanisms related to aging and disease trajectories are discussed.

Authors+Show Affiliations

Department of Psychology, University of Oregon, Eugene, OR, USA. Electronic address: bwn@uoregon.edu.Department of Psychology, University of Oregon, Eugene, OR, USA.Department of Psychology, University of Oregon, Eugene, OR, USA; Department of Psychology, University of Illinois Urbana-Champaign, Champaign, IL, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29161636

Citation

Nelson, Benjamin W., et al. "Infant HPA Axis as a Potential Mechanism Linking Maternal Mental Health and Infant Telomere Length." Psychoneuroendocrinology, vol. 88, 2018, pp. 38-46.
Nelson BW, Allen NB, Laurent H. Infant HPA axis as a potential mechanism linking maternal mental health and infant telomere length. Psychoneuroendocrinology. 2018;88:38-46.
Nelson, B. W., Allen, N. B., & Laurent, H. (2018). Infant HPA axis as a potential mechanism linking maternal mental health and infant telomere length. Psychoneuroendocrinology, 88, 38-46. https://doi.org/10.1016/j.psyneuen.2017.11.008
Nelson BW, Allen NB, Laurent H. Infant HPA Axis as a Potential Mechanism Linking Maternal Mental Health and Infant Telomere Length. Psychoneuroendocrinology. 2018;88:38-46. PubMed PMID: 29161636.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Infant HPA axis as a potential mechanism linking maternal mental health and infant telomere length. AU - Nelson,Benjamin W, AU - Allen,Nicholas B, AU - Laurent,Heidemarie, Y1 - 2017/11/16/ PY - 2017/06/10/received PY - 2017/10/13/revised PY - 2017/11/15/accepted PY - 2017/11/22/pubmed PY - 2019/1/1/medline PY - 2017/11/22/entrez KW - Cortisol KW - Depressive symptoms KW - Infant KW - Maternal mental health KW - Mindfulness KW - Telomere SP - 38 EP - 46 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 88 N2 - Maternal depression has been suggested to be an independent risk factor for both dysregulated hypothalamic-pituitary-adrenal axis (HPA) functioning and shorter telomere length in offspring. In contrast, research suggests that individual differences in mindfulness may act as a protective factor against one's own telomere degradation. Currently, research has yet to investigate the association between longitudinal changes in maternal mental health (depressive symptoms and mindfulness) and salivary infant telomere length, and whether such changes might be mediated by alterations in infant cortisol response. In 48 mother-infant dyads, we investigated whether the changes in maternal mental health, when infants were 6-12 months of age, predicted change in infant cortisol reactivity and recovery over this period. We also investigated whether these changes in infant HPA functioning predicted subsequent infant salivary telomere length at 18 months of age. Furthermore, we investigated whether change in infant HPA functioning provided a potential pathway between changes in maternal mental health factors and infant salivary telomere length. Analyses revealed that increases in maternal depressive symptoms over that six-month period indirectly related to subsequent shorter infant telomere length through increased infant cortisol reactivity. Implications for the ways in which maternal mental health can impact offspring stress mechanisms related to aging and disease trajectories are discussed. SN - 1873-3360 UR - https://www.unboundmedicine.com/medline/citation/29161636/Infant_HPA_axis_as_a_potential_mechanism_linking_maternal_mental_health_and_infant_telomere_length_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(17)30565-6 DB - PRIME DP - Unbound Medicine ER -