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Impact of rotavirus vaccine on acute gastroenteritis in children under 5 years in Senegal: Experience of sentinel site of the Albert Royer Children's Hospital in Dakar.
Vaccine. 2018 11 12; 36(47):7192-7197.V

Abstract

BACKGROUND

Acute gastroenteritis (AGE) is a leading cause of morbidity and mortality among children <5 years of age in developing countries, with rotavirus being the most common infectious etiology. In November 2014, monovalent rotavirus vaccine was introduced in Senegal. We determined the impact of rotavirus vaccine on hospitalizations for all-cause and rotavirus related AGE in children <60 months of age.

METHODS

We examined two data sources from the national referral hospital. Using sentinel surveillance data from March 2011 to February 2017, we examined the proportion of AGE hospitalizations among children <60 months of age attributable to rotavirus, stratified by age groups (0-11, 12-23 and 24-59 months). Using pediatric logbook data from March 2010 to February 2017, we examined the proportion of all childhood hospitalizations attributable to AGE, among the same age groups.

RESULTS

In sentinel surveillance, 673 patients <60 months were hospitalized for AGE, with 30% (203/673) due to rotavirus. In pre-vaccine years, the median proportion of rotavirus-positive hospitalizations was 42%; this proportion declined by 76% to 10% rotavirus positive in 2015-2016 (p < .001) and by 59% to 17% in 2016-2017 (p < .001). From the logbook data, among all children <60 months, a median of 11% of all hospitalizations in the pre-vaccine period were due to AGE, with 2015-2016 seeing a 16% decline (p < .001), to 9% of all hospitalizations, and 2016-2017 seeing a 39% decline (p < .001), to 7% of all hospitalizations. Declines in both rotavirus-associated and all-cause AGE hospitalizations were most marked among infants, with a suggestion of herd effect among older children seen in the surveillance data.

CONCLUSION

Rotavirus vaccine demonstrated a significant impact on rotavirus-associated hospitalizations and all-cause AGE hospitalizations in the first two seasons after vaccine introduction in Senegal. Our data support the continued use of this vaccine in national immunization program.

Authors+Show Affiliations

Bacteriology and Virology Laboratory, Albert Royer Teaching Hospital, Dakar, Senegal. Electronic address: amadoudioplaba@yahoo.fr.Paediatric Unit, Albert Royer Teaching Hospital, Dakar, Senegal.World Health Organization, Regional Office for Africa, Brazzaville, People's Republic of Congo.Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Atlanta, GA, USA.Bacteriology and Virology Laboratory, Albert Royer Teaching Hospital, Dakar, Senegal.Expanded Programme on Immunization Focal Point, World Health Organization Country Office, Dakar, Senegal.Expanded Programme on Immunization, Ministry of Health, Dakar, Senegal.Paediatric Unit, Albert Royer Teaching Hospital, Dakar, Senegal.Paediatric Unit, Albert Royer Teaching Hospital, Dakar, Senegal.Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Atlanta, GA, USA.Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Atlanta, GA, USA.Paediatric Unit, Albert Royer Teaching Hospital, Dakar, Senegal.Bacteriology and Virology Laboratory, Albert Royer Teaching Hospital, Dakar, Senegal.Paediatric Unit, Albert Royer Teaching Hospital, Dakar, Senegal.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29162319

Citation

Diop, Amadou, et al. "Impact of Rotavirus Vaccine On Acute Gastroenteritis in Children Under 5 Years in Senegal: Experience of Sentinel Site of the Albert Royer Children's Hospital in Dakar." Vaccine, vol. 36, no. 47, 2018, pp. 7192-7197.
Diop A, Thiongane A, Mwenda JM, et al. Impact of rotavirus vaccine on acute gastroenteritis in children under 5 years in Senegal: Experience of sentinel site of the Albert Royer Children's Hospital in Dakar. Vaccine. 2018;36(47):7192-7197.
Diop, A., Thiongane, A., Mwenda, J. M., Aliabadi, N., Sonko, M. A., Diallo, A., Ndoye, B., Faye, P. M., Ba, I. D., Parashar, U. D., Tate, J. E., Ndiaye, O., Cissé, M. F., & Ba, M. (2018). Impact of rotavirus vaccine on acute gastroenteritis in children under 5 years in Senegal: Experience of sentinel site of the Albert Royer Children's Hospital in Dakar. Vaccine, 36(47), 7192-7197. https://doi.org/10.1016/j.vaccine.2017.10.061
Diop A, et al. Impact of Rotavirus Vaccine On Acute Gastroenteritis in Children Under 5 Years in Senegal: Experience of Sentinel Site of the Albert Royer Children's Hospital in Dakar. Vaccine. 2018 11 12;36(47):7192-7197. PubMed PMID: 29162319.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of rotavirus vaccine on acute gastroenteritis in children under 5 years in Senegal: Experience of sentinel site of the Albert Royer Children's Hospital in Dakar. AU - Diop,Amadou, AU - Thiongane,Aliou, AU - Mwenda,Jason M, AU - Aliabadi,Negar, AU - Sonko,Mouhamadou A, AU - Diallo,Aliou, AU - Ndoye,Babacar, AU - Faye,Papa M, AU - Ba,Idrissa D, AU - Parashar,Umesh D, AU - Tate,Jacqueline E, AU - Ndiaye,Ousmane, AU - Cissé,Moussa F, AU - Ba,Mamadou, Y1 - 2017/11/20/ PY - 2017/06/05/received PY - 2017/09/30/revised PY - 2017/10/17/accepted PY - 2017/11/23/pubmed PY - 2019/2/15/medline PY - 2017/11/23/entrez KW - Acute gastroenteritis KW - Monovalent rotavirus vaccine KW - Rotavirus KW - Senegal SP - 7192 EP - 7197 JF - Vaccine JO - Vaccine VL - 36 IS - 47 N2 - BACKGROUND: Acute gastroenteritis (AGE) is a leading cause of morbidity and mortality among children <5 years of age in developing countries, with rotavirus being the most common infectious etiology. In November 2014, monovalent rotavirus vaccine was introduced in Senegal. We determined the impact of rotavirus vaccine on hospitalizations for all-cause and rotavirus related AGE in children <60 months of age. METHODS: We examined two data sources from the national referral hospital. Using sentinel surveillance data from March 2011 to February 2017, we examined the proportion of AGE hospitalizations among children <60 months of age attributable to rotavirus, stratified by age groups (0-11, 12-23 and 24-59 months). Using pediatric logbook data from March 2010 to February 2017, we examined the proportion of all childhood hospitalizations attributable to AGE, among the same age groups. RESULTS: In sentinel surveillance, 673 patients <60 months were hospitalized for AGE, with 30% (203/673) due to rotavirus. In pre-vaccine years, the median proportion of rotavirus-positive hospitalizations was 42%; this proportion declined by 76% to 10% rotavirus positive in 2015-2016 (p < .001) and by 59% to 17% in 2016-2017 (p < .001). From the logbook data, among all children <60 months, a median of 11% of all hospitalizations in the pre-vaccine period were due to AGE, with 2015-2016 seeing a 16% decline (p < .001), to 9% of all hospitalizations, and 2016-2017 seeing a 39% decline (p < .001), to 7% of all hospitalizations. Declines in both rotavirus-associated and all-cause AGE hospitalizations were most marked among infants, with a suggestion of herd effect among older children seen in the surveillance data. CONCLUSION: Rotavirus vaccine demonstrated a significant impact on rotavirus-associated hospitalizations and all-cause AGE hospitalizations in the first two seasons after vaccine introduction in Senegal. Our data support the continued use of this vaccine in national immunization program. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/29162319/Impact_of_rotavirus_vaccine_on_acute_gastroenteritis_in_children_under_5_years_in_Senegal:_Experience_of_sentinel_site_of_the_Albert_Royer_Children's_Hospital_in_Dakar_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(17)31469-X DB - PRIME DP - Unbound Medicine ER -