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The effect of exercise intensity on brain derived neurotrophic factor and memory in adolescents.
Environ Health Prev Med. 2017 Apr 04; 22(1):27.EH

Abstract

BACKGROUND

Brain derived neurotrophic factor (BDNF) seems to serve as an important regulatory mechanism in the growth and development of neurons in many areas of the brain.Insulin-like growth factor 1 (IGF-1) is related to neurogenesis and regulation of the BDNF gene and is involved in the growth and differentiation of neurons.Cortisol is released in response to stimuli such as psychological oppression, anxiety, and fear. Stress also induces changes in BDNF. The purpose of this study was thus to examine the effects of varying intensities of aerobic exercise on resting serum BDNF, IGF-1 concentrations, cortisol, and memory of adolescents.

METHODS

Forty male students with no history of physical illness from the middle school by participated in this study. Participants were randomly assigned to low, moderate, or high intensity treadmill exercise group, or a stretching (control) group. Exercise was performed 4 times per week for 12 weeks. Body composition, brain derived neurotrophic factor levels, insulin-like growth factor 1 levels, cortisol levels, and working memory were assessed.

RESULTS

The high intensity exercise group showed a significant increase in brain derived neurotrophic factor at rest, concentration level of insulin-like growth factor 1, cortisol, and working memory. For resting brain derived neurotrophic factor, the high intensity exercise group showed a more significant increase compared to the low intensity aerobic and stretching groups. The change in the working memory significantly increased for the high intensity exercise group compared to the low intensity aerobic group, moderate intensity exercise group, and stretching group.

CONCLUSIONS

In adolescents, whose brains are still developing, aerobic exercise of moderate to high intensity levels seems to have a positive effect on levels of serum brain derived neurotrophic factor at rest and on cognitive functioning.

TRIAL REGISTRATION

EHPM-D-16-00107R2 . ICMJE. 12 July 2016.

Authors+Show Affiliations

Department of Physical Education, Dankook University, Yongin, Republic of Korea.Department Human Performance and Leisure Studies, North Carolina A&T State University, 1601 E. Market Street, Greensboro, NC, 27411, USA. changhoha00@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29165142

Citation

Jeon, Yong Kyun, and Chang Ho Ha. "The Effect of Exercise Intensity On Brain Derived Neurotrophic Factor and Memory in Adolescents." Environmental Health and Preventive Medicine, vol. 22, no. 1, 2017, p. 27.
Jeon YK, Ha CH. The effect of exercise intensity on brain derived neurotrophic factor and memory in adolescents. Environ Health Prev Med. 2017;22(1):27.
Jeon, Y. K., & Ha, C. H. (2017). The effect of exercise intensity on brain derived neurotrophic factor and memory in adolescents. Environmental Health and Preventive Medicine, 22(1), 27. https://doi.org/10.1186/s12199-017-0643-6
Jeon YK, Ha CH. The Effect of Exercise Intensity On Brain Derived Neurotrophic Factor and Memory in Adolescents. Environ Health Prev Med. 2017 Apr 4;22(1):27. PubMed PMID: 29165142.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of exercise intensity on brain derived neurotrophic factor and memory in adolescents. AU - Jeon,Yong Kyun, AU - Ha,Chang Ho, Y1 - 2017/04/04/ PY - 2017/01/18/received PY - 2017/02/01/accepted PY - 2017/11/23/entrez PY - 2017/11/23/pubmed PY - 2018/6/19/medline KW - BDNF KW - Exercise intensity KW - Memory SP - 27 EP - 27 JF - Environmental health and preventive medicine JO - Environ Health Prev Med VL - 22 IS - 1 N2 - BACKGROUND: Brain derived neurotrophic factor (BDNF) seems to serve as an important regulatory mechanism in the growth and development of neurons in many areas of the brain.Insulin-like growth factor 1 (IGF-1) is related to neurogenesis and regulation of the BDNF gene and is involved in the growth and differentiation of neurons.Cortisol is released in response to stimuli such as psychological oppression, anxiety, and fear. Stress also induces changes in BDNF. The purpose of this study was thus to examine the effects of varying intensities of aerobic exercise on resting serum BDNF, IGF-1 concentrations, cortisol, and memory of adolescents. METHODS: Forty male students with no history of physical illness from the middle school by participated in this study. Participants were randomly assigned to low, moderate, or high intensity treadmill exercise group, or a stretching (control) group. Exercise was performed 4 times per week for 12 weeks. Body composition, brain derived neurotrophic factor levels, insulin-like growth factor 1 levels, cortisol levels, and working memory were assessed. RESULTS: The high intensity exercise group showed a significant increase in brain derived neurotrophic factor at rest, concentration level of insulin-like growth factor 1, cortisol, and working memory. For resting brain derived neurotrophic factor, the high intensity exercise group showed a more significant increase compared to the low intensity aerobic and stretching groups. The change in the working memory significantly increased for the high intensity exercise group compared to the low intensity aerobic group, moderate intensity exercise group, and stretching group. CONCLUSIONS: In adolescents, whose brains are still developing, aerobic exercise of moderate to high intensity levels seems to have a positive effect on levels of serum brain derived neurotrophic factor at rest and on cognitive functioning. TRIAL REGISTRATION: EHPM-D-16-00107R2 . ICMJE. 12 July 2016. SN - 1347-4715 UR - https://www.unboundmedicine.com/medline/citation/29165142/The_effect_of_exercise_intensity_on_brain_derived_neurotrophic_factor_and_memory_in_adolescents_ L2 - https://environhealthprevmed.biomedcentral.com/articles/10.1186/s12199-017-0643-6 DB - PRIME DP - Unbound Medicine ER -