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Various Diagnostic Measures of Frailty as Predictors for Falls, Weight Change, Quality of Life, and Mortality among Older Finnish Men.
J Frailty Aging 2017; 6(4):188-194JF

Abstract

BACKGROUND

Frailty predisposes individuals to a variety of complications. However, there is no consensus on the definition of frailty.

OBJECTIVES

To examine whether various frailty measures are equivalent in identifying the same individuals as being frail and whether the measures also predict similar outcomes.

DESIGN, SETTING AND PARTICIPANTS

The Helsinki Businessmen Study cohort, which is a long-term observational study of men born in 1919-1934, was used as the population. We investigated these men by their postal questionnaire responses in 2000 and 2005. The mean age of the men (N=480) was 73 years at the start of follow-up.

MEASUREMENTS

We compared two phenotypic frailty measures, the Helsinki Businessmen Study measure (HBS), the modified Women's Health Initiative Observational Study (WHI-OS), and the Frailty Index (FI) comprising 20 items. All three measurements were applied to Helsinki Businessmen Study cohort data collected via simple postal questionnaire from 480 men. We investigated how effectively these three measures distinguished between the not frail, prefrail, and frail individuals, and predicted mortality, falls, weight change, and health-related quality of life (HRQoL, 15D instrument) during a 5-year follow-up.

RESULTS

The HBS and the modified WHI-OS identified 35 persons (7.3%) each as frail but their respective sets comprised different groupings of individuals that partly overlapped. The FI identified 86 persons (17.9%) as frail. One-hundred-and-two (21.3%) men were classified as frail by at least one of the measures. All three measures significantly predicted higher mortality, higher number of fallers, and lower HRQoL for frail participants. None of the measures showed different results for weight change between the frailty groups or frailty stages.

CONCLUSIONS

All three measures identified somewhat different sets of participants as frail. They all predicted increased mortality, falls and reduced HRQoL for the frail groups.

Authors+Show Affiliations

N.M. Perttila, University of Helsinki, Department of General Practice and Unit of Primary Health Care, Helsinki University Hospital, P.O. Box 20 (Tukholmankatu 8 B), FI-00014 University of Helsinki, Finland. E-mail: niko.perttila@helsinki.fi.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29165534

Citation

Perttila, N M., et al. "Various Diagnostic Measures of Frailty as Predictors for Falls, Weight Change, Quality of Life, and Mortality Among Older Finnish Men." The Journal of Frailty & Aging, vol. 6, no. 4, 2017, pp. 188-194.
Perttila NM, Pitkala KH, Kautiainen H, et al. Various Diagnostic Measures of Frailty as Predictors for Falls, Weight Change, Quality of Life, and Mortality among Older Finnish Men. J Frailty Aging. 2017;6(4):188-194.
Perttila, N. M., Pitkala, K. H., Kautiainen, H., Tilvis, R., & Stranberg, T. (2017). Various Diagnostic Measures of Frailty as Predictors for Falls, Weight Change, Quality of Life, and Mortality among Older Finnish Men. The Journal of Frailty & Aging, 6(4), pp. 188-194. doi:10.14283/jfa.2017.26.
Perttila NM, et al. Various Diagnostic Measures of Frailty as Predictors for Falls, Weight Change, Quality of Life, and Mortality Among Older Finnish Men. J Frailty Aging. 2017;6(4):188-194. PubMed PMID: 29165534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Various Diagnostic Measures of Frailty as Predictors for Falls, Weight Change, Quality of Life, and Mortality among Older Finnish Men. AU - Perttila,N M, AU - Pitkala,K H, AU - Kautiainen,H, AU - Tilvis,R, AU - Stranberg,T, PY - 2017/11/23/entrez PY - 2017/11/23/pubmed PY - 2018/4/11/medline KW - Prevalence KW - falls KW - frail elderly KW - life expectancy KW - quality of life SP - 188 EP - 194 JF - The Journal of frailty & aging JO - J Frailty Aging VL - 6 IS - 4 N2 - BACKGROUND: Frailty predisposes individuals to a variety of complications. However, there is no consensus on the definition of frailty. OBJECTIVES: To examine whether various frailty measures are equivalent in identifying the same individuals as being frail and whether the measures also predict similar outcomes. DESIGN, SETTING AND PARTICIPANTS: The Helsinki Businessmen Study cohort, which is a long-term observational study of men born in 1919-1934, was used as the population. We investigated these men by their postal questionnaire responses in 2000 and 2005. The mean age of the men (N=480) was 73 years at the start of follow-up. MEASUREMENTS: We compared two phenotypic frailty measures, the Helsinki Businessmen Study measure (HBS), the modified Women's Health Initiative Observational Study (WHI-OS), and the Frailty Index (FI) comprising 20 items. All three measurements were applied to Helsinki Businessmen Study cohort data collected via simple postal questionnaire from 480 men. We investigated how effectively these three measures distinguished between the not frail, prefrail, and frail individuals, and predicted mortality, falls, weight change, and health-related quality of life (HRQoL, 15D instrument) during a 5-year follow-up. RESULTS: The HBS and the modified WHI-OS identified 35 persons (7.3%) each as frail but their respective sets comprised different groupings of individuals that partly overlapped. The FI identified 86 persons (17.9%) as frail. One-hundred-and-two (21.3%) men were classified as frail by at least one of the measures. All three measures significantly predicted higher mortality, higher number of fallers, and lower HRQoL for frail participants. None of the measures showed different results for weight change between the frailty groups or frailty stages. CONCLUSIONS: All three measures identified somewhat different sets of participants as frail. They all predicted increased mortality, falls and reduced HRQoL for the frail groups. SN - 2260-1341 UR - https://www.unboundmedicine.com/medline/citation/29165534/Various_Diagnostic_Measures_of_Frailty_as_Predictors_for_Falls_Weight_Change_Quality_of_Life_and_Mortality_among_Older_Finnish_Men_ L2 - https://medlineplus.gov/falls.html DB - PRIME DP - Unbound Medicine ER -