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Effects of urban coarse particles inhalation on oxidative and inflammatory parameters in the mouse lung and colon.
Part Fibre Toxicol. 2017 11 22; 14(1):46.PF

Abstract

BACKGROUND

Air pollution is a recognized aggravating factor for pulmonary diseases and has notably deleterious effects on asthma, bronchitis and pneumonia. Recent studies suggest that air pollution may also cause adverse effects in the gastrointestinal tract. Accumulating experimental evidence shows that immune responses in the pulmonary and intestinal mucosae are closely interrelated, and that gut-lung crosstalk controls pathophysiological processes such as responses to cigarette smoke and influenza virus infection. Our first aim was to collect urban coarse particulate matter (PM) and to characterize them for elemental content, gastric bioaccessibility, and oxidative potential; our second aim was to determine the short-term effects of urban coarse PM inhalation on pulmonary and colonic mucosae in mice, and to test the hypothesis that the well-known antioxidant N-acetyl-L-cysteine (NAC) reverses the effects of PM inhalation.

RESULTS

The collected PM had classical features of urban particles and possessed oxidative potential partly attributable to their metal fraction. Bioaccessibility study confirmed the high solubility of some metals at the gastric level. Male mice were exposed to urban coarse PM in a ventilated inhalation chamber for 15 days at a concentration relevant to episodic elevation peak of air pollution. Coarse PM inhalation induced systemic oxidative stress, recruited immune cells to the lung, and increased cytokine levels in the lung and colon. Concomitant oral administration of NAC reversed all the observed effects relative to the inhalation of coarse PM.

CONCLUSIONS

Coarse PM-induced low-grade inflammation in the lung and colon is mediated by oxidative stress and deserves more investigation as potentiating factor for inflammatory diseases.

Authors+Show Affiliations

Inserm, CHU Lille, U995-LIRIC-Lille Inflammation Research International Center, Univ. Lille, F-59000, Lille, France.Inserm U1019, CNRS UMR 8204, Institut Pasteur de Lille- CIIL - Center for Infection and Immunity of Lille, Univ. Lille, F-59000, Lille, France.SAGE - Département Sciences de l'Atmosphère et Génie de l'Environnement, IMT Lille Douai, Univ. Lille, 59000, Lille, France.Inserm, CHU Lille, U995-LIRIC-Lille Inflammation Research International Center, Univ. Lille, F-59000, Lille, France.Inserm, CHU Lille, U995-LIRIC-Lille Inflammation Research International Center, Univ. Lille, F-59000, Lille, France.SAGE - Département Sciences de l'Atmosphère et Génie de l'Environnement, IMT Lille Douai, Univ. Lille, 59000, Lille, France.Inserm, CHU Lille, U995-LIRIC-Lille Inflammation Research International Center, Univ. Lille, F-59000, Lille, France.Inserm U1019, CNRS UMR 8204, Institut Pasteur de Lille- CIIL - Center for Infection and Immunity of Lille, Univ. Lille, F-59000, Lille, France.Inserm, CHU Lille, U995-LIRIC-Lille Inflammation Research International Center, Univ. Lille, F-59000, Lille, France.Inserm, CHU Lille, U995-LIRIC-Lille Inflammation Research International Center, Univ. Lille, F-59000, Lille, France.Inserm, CHU Lille, U995-LIRIC-Lille Inflammation Research International Center, Univ. Lille, F-59000, Lille, France. mathilde.body@univ-lille2.fr.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29166940

Citation

Vignal, Cécile, et al. "Effects of Urban Coarse Particles Inhalation On Oxidative and Inflammatory Parameters in the Mouse Lung and Colon." Particle and Fibre Toxicology, vol. 14, no. 1, 2017, p. 46.
Vignal C, Pichavant M, Alleman LY, et al. Effects of urban coarse particles inhalation on oxidative and inflammatory parameters in the mouse lung and colon. Part Fibre Toxicol. 2017;14(1):46.
Vignal, C., Pichavant, M., Alleman, L. Y., Djouina, M., Dingreville, F., Perdrix, E., Waxin, C., Ouali Alami, A., Gower-Rousseau, C., Desreumaux, P., & Body-Malapel, M. (2017). Effects of urban coarse particles inhalation on oxidative and inflammatory parameters in the mouse lung and colon. Particle and Fibre Toxicology, 14(1), 46. https://doi.org/10.1186/s12989-017-0227-z
Vignal C, et al. Effects of Urban Coarse Particles Inhalation On Oxidative and Inflammatory Parameters in the Mouse Lung and Colon. Part Fibre Toxicol. 2017 11 22;14(1):46. PubMed PMID: 29166940.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of urban coarse particles inhalation on oxidative and inflammatory parameters in the mouse lung and colon. AU - Vignal,Cécile, AU - Pichavant,Muriel, AU - Alleman,Laurent Y, AU - Djouina,Madjid, AU - Dingreville,Florian, AU - Perdrix,Esperanza, AU - Waxin,Christophe, AU - Ouali Alami,Adil, AU - Gower-Rousseau,Corinne, AU - Desreumaux,Pierre, AU - Body-Malapel,Mathilde, Y1 - 2017/11/22/ PY - 2017/02/27/received PY - 2017/11/10/accepted PY - 2017/11/24/entrez PY - 2017/11/24/pubmed PY - 2018/8/28/medline KW - Coarse PM KW - Gut-lung axis KW - Inflammation KW - N-acetyl-L-cysteine KW - Oxidative stress KW - Particulate matter SP - 46 EP - 46 JF - Particle and fibre toxicology JO - Part Fibre Toxicol VL - 14 IS - 1 N2 - BACKGROUND: Air pollution is a recognized aggravating factor for pulmonary diseases and has notably deleterious effects on asthma, bronchitis and pneumonia. Recent studies suggest that air pollution may also cause adverse effects in the gastrointestinal tract. Accumulating experimental evidence shows that immune responses in the pulmonary and intestinal mucosae are closely interrelated, and that gut-lung crosstalk controls pathophysiological processes such as responses to cigarette smoke and influenza virus infection. Our first aim was to collect urban coarse particulate matter (PM) and to characterize them for elemental content, gastric bioaccessibility, and oxidative potential; our second aim was to determine the short-term effects of urban coarse PM inhalation on pulmonary and colonic mucosae in mice, and to test the hypothesis that the well-known antioxidant N-acetyl-L-cysteine (NAC) reverses the effects of PM inhalation. RESULTS: The collected PM had classical features of urban particles and possessed oxidative potential partly attributable to their metal fraction. Bioaccessibility study confirmed the high solubility of some metals at the gastric level. Male mice were exposed to urban coarse PM in a ventilated inhalation chamber for 15 days at a concentration relevant to episodic elevation peak of air pollution. Coarse PM inhalation induced systemic oxidative stress, recruited immune cells to the lung, and increased cytokine levels in the lung and colon. Concomitant oral administration of NAC reversed all the observed effects relative to the inhalation of coarse PM. CONCLUSIONS: Coarse PM-induced low-grade inflammation in the lung and colon is mediated by oxidative stress and deserves more investigation as potentiating factor for inflammatory diseases. SN - 1743-8977 UR - https://www.unboundmedicine.com/medline/citation/29166940/Effects_of_urban_coarse_particles_inhalation_on_oxidative_and_inflammatory_parameters_in_the_mouse_lung_and_colon_ L2 - https://particleandfibretoxicology.biomedcentral.com/articles/10.1186/s12989-017-0227-z DB - PRIME DP - Unbound Medicine ER -