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Tree nut, peanut, and peanut butter intake and risk of postmenopausal breast cancer: The Netherlands Cohort Study.
Cancer Causes Control. 2018 01; 29(1):63-75.CC

Abstract

PURPOSE

Nut intake has been associated with reduced mortality and risk of cardiovascular diseases, but there is only limited evidence on cancer. We investigated the relationship between nut intake and risk of postmenopausal breast cancer, and estrogen/progesterone receptor (ER/PR) subtypes.

METHODS

In The Netherlands Cohort Study, 62,573 women aged 55-69 years provided information on dietary and lifestyle habits in 1986. After 20.3 years of follow-up, 2,321 incident breast cancer cases and 1,665 subcohort members were eligible for multivariate case-cohort analyses.

RESULTS

Total nut intake was significantly inversely related to ER negative (ER -) breast cancer risk, with HR 0.55 (95% CI 0.33-0.93) for those consuming at least 10 g nuts/day versus non-consumers (p trend = 0.025). There were no significant inverse associations with ER + or total breast cancer. While there was no variation between PR subtypes, the ER-PR- subtype was also significantly inversely associated with nut intake, with HR 0.53 (95% CI 0.29-0.99), p trend = 0.037. Intake of peanuts and tree nuts separately was also inversely related to ER - breast cancer subtypes, while no associations were found with peanut butter intake.

CONCLUSIONS

Our findings suggest an inverse association between nut intake and ER - breast cancer, and no association with total or hormone receptor-positive subtypes.

Authors+Show Affiliations

Department of Epidemiology, Maastricht University Medical Centre, Care and Public Health Research Institute (CAPHRI), Maastricht, The Netherlands. PA.vandenBrandt@maastrichtuniversity.nl. Department of Epidemiology, GROW- School for Oncology and Developmental Biology, Maastricht University Medical Centre, PO Box 616, 6200 MD, Maastricht, The Netherlands. PA.vandenBrandt@maastrichtuniversity.nl.Department of Epidemiology, Maastricht University Medical Centre, Care and Public Health Research Institute (CAPHRI), Maastricht, The Netherlands.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29168062

Citation

van den Brandt, Piet A., and Lisette Nieuwenhuis. "Tree Nut, Peanut, and Peanut Butter Intake and Risk of Postmenopausal Breast Cancer: the Netherlands Cohort Study." Cancer Causes & Control : CCC, vol. 29, no. 1, 2018, pp. 63-75.
van den Brandt PA, Nieuwenhuis L. Tree nut, peanut, and peanut butter intake and risk of postmenopausal breast cancer: The Netherlands Cohort Study. Cancer Causes Control. 2018;29(1):63-75.
van den Brandt, P. A., & Nieuwenhuis, L. (2018). Tree nut, peanut, and peanut butter intake and risk of postmenopausal breast cancer: The Netherlands Cohort Study. Cancer Causes & Control : CCC, 29(1), 63-75. https://doi.org/10.1007/s10552-017-0979-7
van den Brandt PA, Nieuwenhuis L. Tree Nut, Peanut, and Peanut Butter Intake and Risk of Postmenopausal Breast Cancer: the Netherlands Cohort Study. Cancer Causes Control. 2018;29(1):63-75. PubMed PMID: 29168062.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tree nut, peanut, and peanut butter intake and risk of postmenopausal breast cancer: The Netherlands Cohort Study. AU - van den Brandt,Piet A, AU - Nieuwenhuis,Lisette, Y1 - 2017/11/22/ PY - 2017/07/19/received PY - 2017/10/30/accepted PY - 2017/11/24/pubmed PY - 2019/4/4/medline PY - 2017/11/24/entrez KW - Breast cancer KW - Cohort study KW - Nuts KW - Peanut butter KW - Peanuts SP - 63 EP - 75 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 29 IS - 1 N2 - PURPOSE: Nut intake has been associated with reduced mortality and risk of cardiovascular diseases, but there is only limited evidence on cancer. We investigated the relationship between nut intake and risk of postmenopausal breast cancer, and estrogen/progesterone receptor (ER/PR) subtypes. METHODS: In The Netherlands Cohort Study, 62,573 women aged 55-69 years provided information on dietary and lifestyle habits in 1986. After 20.3 years of follow-up, 2,321 incident breast cancer cases and 1,665 subcohort members were eligible for multivariate case-cohort analyses. RESULTS: Total nut intake was significantly inversely related to ER negative (ER -) breast cancer risk, with HR 0.55 (95% CI 0.33-0.93) for those consuming at least 10 g nuts/day versus non-consumers (p trend = 0.025). There were no significant inverse associations with ER + or total breast cancer. While there was no variation between PR subtypes, the ER-PR- subtype was also significantly inversely associated with nut intake, with HR 0.53 (95% CI 0.29-0.99), p trend = 0.037. Intake of peanuts and tree nuts separately was also inversely related to ER - breast cancer subtypes, while no associations were found with peanut butter intake. CONCLUSIONS: Our findings suggest an inverse association between nut intake and ER - breast cancer, and no association with total or hormone receptor-positive subtypes. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/29168062/Tree_nut_peanut_and_peanut_butter_intake_and_risk_of_postmenopausal_breast_cancer:_The_Netherlands_Cohort_Study_ L2 - https://doi.org/10.1007/s10552-017-0979-7 DB - PRIME DP - Unbound Medicine ER -