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Significance of Histoplasma antigen in the cerebrospinal fluid of patients with meningitis.
Arch Intern Med. 1989 Feb; 149(2):302-4.AI

Abstract

A radioimmunoassay was previously developed for detection of Histoplasma capsulatum antigen in the blood and urine of patients with disseminated histoplasmosis. In this investigation, cerebrospinal fluid (CSF) specimens from 14 episodes of Histoplasma meningitis occurring in 12 patients were tested by radioimmunoassay. Histoplasma capsulatum antigen was detected in the CSF of five patients. Cerebrospinal fluid cultures were positive for H capsulatum in three of these five patients. Antibodies to H capsulatum were found in nine of the 13 CSF specimens tested. The radioimmunoassay for Histoplasma antigen was also positive in the CSF in one of 11 patients with coccidioidal meningitis but not in 17 patients with cryptococcal meningitis. It was concluded that Histoplasma antigen is present in the CSF of some patients with histoplasmosis and chronic meningitis, but cross-reactions may occur in patients with coccidioidal meningitis.

Authors+Show Affiliations

Wishard Memorial Hospital, Indiana University School of Medicine, Indianapolis 46202.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2916875

Citation

Wheat, L J., et al. "Significance of Histoplasma Antigen in the Cerebrospinal Fluid of Patients With Meningitis." Archives of Internal Medicine, vol. 149, no. 2, 1989, pp. 302-4.
Wheat LJ, Kohler RB, Tewari RP, et al. Significance of Histoplasma antigen in the cerebrospinal fluid of patients with meningitis. Arch Intern Med. 1989;149(2):302-4.
Wheat, L. J., Kohler, R. B., Tewari, R. P., Garten, M., & French, M. L. (1989). Significance of Histoplasma antigen in the cerebrospinal fluid of patients with meningitis. Archives of Internal Medicine, 149(2), 302-4.
Wheat LJ, et al. Significance of Histoplasma Antigen in the Cerebrospinal Fluid of Patients With Meningitis. Arch Intern Med. 1989;149(2):302-4. PubMed PMID: 2916875.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Significance of Histoplasma antigen in the cerebrospinal fluid of patients with meningitis. AU - Wheat,L J, AU - Kohler,R B, AU - Tewari,R P, AU - Garten,M, AU - French,M L, PY - 1989/2/1/pubmed PY - 1989/2/1/medline PY - 1989/2/1/entrez SP - 302 EP - 4 JF - Archives of internal medicine JO - Arch Intern Med VL - 149 IS - 2 N2 - A radioimmunoassay was previously developed for detection of Histoplasma capsulatum antigen in the blood and urine of patients with disseminated histoplasmosis. In this investigation, cerebrospinal fluid (CSF) specimens from 14 episodes of Histoplasma meningitis occurring in 12 patients were tested by radioimmunoassay. Histoplasma capsulatum antigen was detected in the CSF of five patients. Cerebrospinal fluid cultures were positive for H capsulatum in three of these five patients. Antibodies to H capsulatum were found in nine of the 13 CSF specimens tested. The radioimmunoassay for Histoplasma antigen was also positive in the CSF in one of 11 patients with coccidioidal meningitis but not in 17 patients with cryptococcal meningitis. It was concluded that Histoplasma antigen is present in the CSF of some patients with histoplasmosis and chronic meningitis, but cross-reactions may occur in patients with coccidioidal meningitis. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/2916875/Significance_of_Histoplasma_antigen_in_the_cerebrospinal_fluid_of_patients_with_meningitis_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/149/pg/302 DB - PRIME DP - Unbound Medicine ER -