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Role of Vitamin E in the Treatment of Alzheimer's Disease: Evidence from Animal Models.
Int J Mol Sci. 2017 Nov 23; 18(12)IJ

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder representing the major cause of dementia. It is characterized by memory loss, and cognitive and behavioral decline. In particular, the hallmarks of the pathology are amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs), formed by aggregated hyperphosphorylated tau protein. Oxidative stress plays a main role in AD, and it is involved in initiation and progression of AD. It is well known that Aβ induced oxidative stress, promoting reactive oxygen species (ROS) production and consequently lipid peroxidation, protein oxidation, tau hyperphosphorylation, results in toxic effects on synapses and neurons. In turn, oxidative stress can increase Aβ production. For these reasons, the administration of an antioxidant therapy in AD patients was suggested. The term vitamin E includes different fat-soluble compounds, divided into tocopherols and tocotrienols, that possess antioxidant action. α-Tocopherol is the most studied, but some studies suggested that tocotrienols may have different health promoting capacities. In this review, we focused our attention on the effects of vitamin E supplementation in AD animal models and AD patients or older population. Experimental models showed that vitamin E supplementation, by decreasing oxidative stress, may be a good strategy to improve cognitive and memory deficits. Furthermore, the combination of vitamin E with other antioxidant or anti-inflammatory compounds may increase its efficacy. However, even if some trials have evidenced some benefits, the effects of vitamin E in AD patients are still under debate.

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Authors+Show Affiliations

Gugliandolo A
IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. agnesegugli@hotmail.it.
Bramanti P
IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. bramanti.dino@gmail.com.
Mazzon E
IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. emanuela.mazzon@irccsme.it.

MeSH

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsAntioxidantsClinical Trials as TopicDietary SupplementsDisease Models, AnimalDrug Evaluation, PreclinicalDrug Therapy, CombinationHumansOxidative StressProtein Aggregation, PathologicalReactive Oxygen SpeciesTreatment OutcomeVitamin Etau Proteins

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29168797

Citation

Gugliandolo, Agnese, et al. "Role of Vitamin E in the Treatment of Alzheimer's Disease: Evidence From Animal Models." International Journal of Molecular Sciences, vol. 18, no. 12, 2017.
Gugliandolo A, Bramanti P, Mazzon E. Role of Vitamin E in the Treatment of Alzheimer's Disease: Evidence from Animal Models. Int J Mol Sci. 2017;18(12).
Gugliandolo, A., Bramanti, P., & Mazzon, E. (2017). Role of Vitamin E in the Treatment of Alzheimer's Disease: Evidence from Animal Models. International Journal of Molecular Sciences, 18(12). https://doi.org/10.3390/ijms18122504
Gugliandolo A, Bramanti P, Mazzon E. Role of Vitamin E in the Treatment of Alzheimer's Disease: Evidence From Animal Models. Int J Mol Sci. 2017 Nov 23;18(12) PubMed PMID: 29168797.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of Vitamin E in the Treatment of Alzheimer's Disease: Evidence from Animal Models. AU - Gugliandolo,Agnese, AU - Bramanti,Placido, AU - Mazzon,Emanuela, Y1 - 2017/11/23/ PY - 2017/09/27/received PY - 2017/10/27/revised PY - 2017/11/20/accepted PY - 2017/11/24/entrez PY - 2017/11/24/pubmed PY - 2018/7/4/medline KW - Alzheimer’s disease KW - tocopherol KW - tocotrienol KW - vitamin E JF - International journal of molecular sciences JO - Int J Mol Sci VL - 18 IS - 12 N2 - Alzheimer's disease (AD) is a neurodegenerative disorder representing the major cause of dementia. It is characterized by memory loss, and cognitive and behavioral decline. In particular, the hallmarks of the pathology are amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs), formed by aggregated hyperphosphorylated tau protein. Oxidative stress plays a main role in AD, and it is involved in initiation and progression of AD. It is well known that Aβ induced oxidative stress, promoting reactive oxygen species (ROS) production and consequently lipid peroxidation, protein oxidation, tau hyperphosphorylation, results in toxic effects on synapses and neurons. In turn, oxidative stress can increase Aβ production. For these reasons, the administration of an antioxidant therapy in AD patients was suggested. The term vitamin E includes different fat-soluble compounds, divided into tocopherols and tocotrienols, that possess antioxidant action. α-Tocopherol is the most studied, but some studies suggested that tocotrienols may have different health promoting capacities. In this review, we focused our attention on the effects of vitamin E supplementation in AD animal models and AD patients or older population. Experimental models showed that vitamin E supplementation, by decreasing oxidative stress, may be a good strategy to improve cognitive and memory deficits. Furthermore, the combination of vitamin E with other antioxidant or anti-inflammatory compounds may increase its efficacy. However, even if some trials have evidenced some benefits, the effects of vitamin E in AD patients are still under debate. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/29168797/Role_of_Vitamin_E_in_the_Treatment_of_Alzheimer's_Disease:_Evidence_from_Animal_Models_ DB - PRIME DP - Unbound Medicine ER -