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A review of hydrogen sulfide (H2S) donors: Chemistry and potential therapeutic applications.
Biochem Pharmacol. 2018 03; 149:110-123.BP

Abstract

Hydrogen sulfide (H2S) is a ubiquitous small gaseous signaling molecule, playing an important role in many physiological processes and joining nitric oxide and carbon monoxide in the group of signaling agents termed gasotransmitters. Endogenous concentrations of H2S are generally low, making it difficult to discern precise biological functions. As such, probing the physiological roles of H2S is aided by exogenous delivery of the gas in cell and animal studies. This need for an exogenous source of H2S provides a unique challenge for chemists to develop chemical tools that facilitate the study of H2S under biological conditions. Compounds that degrade in response to a specific trigger to release H2S, termed H2S donors, include a wide variety of functional groups and delivery systems, some of which mimic the tightly controlled endogenous production in response to specific, biologically relevant conditions. This review examines a variety of H2S donor systems classified by their H2S-releasing trigger as well as their H2S release profiles, byproducts, and potential therapeutic applications.

Authors+Show Affiliations

Department of Chemistry, Virginia Tech Center for Drug Discovery, and Macromolecules Innovation Institute, Virginia Tech, Blacksburg, VA 24061, United States.Department of Chemistry, Virginia Tech Center for Drug Discovery, and Macromolecules Innovation Institute, Virginia Tech, Blacksburg, VA 24061, United States.Department of Chemistry, Virginia Tech Center for Drug Discovery, and Macromolecules Innovation Institute, Virginia Tech, Blacksburg, VA 24061, United States. Electronic address: jbmatson@vt.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

29175421

Citation

Powell, Chadwick R., et al. "A Review of Hydrogen Sulfide (H2S) Donors: Chemistry and Potential Therapeutic Applications." Biochemical Pharmacology, vol. 149, 2018, pp. 110-123.
Powell CR, Dillon KM, Matson JB. A review of hydrogen sulfide (H2S) donors: Chemistry and potential therapeutic applications. Biochem Pharmacol. 2018;149:110-123.
Powell, C. R., Dillon, K. M., & Matson, J. B. (2018). A review of hydrogen sulfide (H2S) donors: Chemistry and potential therapeutic applications. Biochemical Pharmacology, 149, 110-123. https://doi.org/10.1016/j.bcp.2017.11.014
Powell CR, Dillon KM, Matson JB. A Review of Hydrogen Sulfide (H2S) Donors: Chemistry and Potential Therapeutic Applications. Biochem Pharmacol. 2018;149:110-123. PubMed PMID: 29175421.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A review of hydrogen sulfide (H2S) donors: Chemistry and potential therapeutic applications. AU - Powell,Chadwick R, AU - Dillon,Kearsley M, AU - Matson,John B, Y1 - 2017/11/23/ PY - 2017/10/31/received PY - 2017/11/21/accepted PY - 2017/11/28/pubmed PY - 2018/12/12/medline PY - 2017/11/28/entrez KW - Carbonyl sulfide KW - Cell signaling KW - Gasotransmitter KW - Perthiols KW - Self-immolation SP - 110 EP - 123 JF - Biochemical pharmacology JO - Biochem. Pharmacol. VL - 149 N2 - Hydrogen sulfide (H2S) is a ubiquitous small gaseous signaling molecule, playing an important role in many physiological processes and joining nitric oxide and carbon monoxide in the group of signaling agents termed gasotransmitters. Endogenous concentrations of H2S are generally low, making it difficult to discern precise biological functions. As such, probing the physiological roles of H2S is aided by exogenous delivery of the gas in cell and animal studies. This need for an exogenous source of H2S provides a unique challenge for chemists to develop chemical tools that facilitate the study of H2S under biological conditions. Compounds that degrade in response to a specific trigger to release H2S, termed H2S donors, include a wide variety of functional groups and delivery systems, some of which mimic the tightly controlled endogenous production in response to specific, biologically relevant conditions. This review examines a variety of H2S donor systems classified by their H2S-releasing trigger as well as their H2S release profiles, byproducts, and potential therapeutic applications. SN - 1873-2968 UR - https://www.unboundmedicine.com/medline/citation/29175421/A_review_of_hydrogen_sulfide__H2S__donors:_Chemistry_and_potential_therapeutic_applications_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-2952(17)30695-0 DB - PRIME DP - Unbound Medicine ER -