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Diffusion tensor imaging identifies presymptomatic axonal degeneration in the spinal cord of ALS mice.
Brain Res. 2018 01 15; 1679:45-52.BR

Abstract

Extensive pathological evidence indicates that axonal degeneration represents an early and critical event in amyotrophic lateral sclerosis (ALS). Unfortunately, few MRI studies have focused in the early detection of white matter (WM) alterations in the spinal cord region. To unveil these WM changes, we performed high resolution diffusion tensor imaging (DTI) and correlated the results with histological analysis of adjacent slices taken from the spinal cords of presymptomatic mice. The DTI studies demonstrated a significant reduction in fractional anisotropy (FA) as well as axial diffusivities (AD) and an increase in radial diffusivity (RD), predominantly at lower segments of the spinal cord. Increases in FA and a reduction in AD and RD were observed in spinal cord (SC) gray matter (GM). Diffusion changes are associated with early and progressive alterations in axonal connectivity following a distal to proximal progression. Histological data tagging neuronal, axonal and glial cell markers demonstrated presymptomatic alterations in spinal cord WM and GM. This study demonstrates that DTI methods are optimal preclinical imaging tools to detect structural anomalies in WM and GM spinal cord during early stages of the disease.

Authors+Show Affiliations

Department of Anatomy and Cell Biology, University of Illinois at Chicago, College of Medicine, Chicago, IL 60612, USA. Electronic address: rgatto@uic.edu.Department of Bioengineering, University of Illinois at Chicago, School of Engineering, Chicago, IL 60612, USA.Department of Bioengineering, University of Illinois at Chicago, School of Engineering, Chicago, IL 60612, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29175489

Citation

Gatto, Rodolfo G., et al. "Diffusion Tensor Imaging Identifies Presymptomatic Axonal Degeneration in the Spinal Cord of ALS Mice." Brain Research, vol. 1679, 2018, pp. 45-52.
Gatto RG, Li W, Magin RL. Diffusion tensor imaging identifies presymptomatic axonal degeneration in the spinal cord of ALS mice. Brain Res. 2018;1679:45-52.
Gatto, R. G., Li, W., & Magin, R. L. (2018). Diffusion tensor imaging identifies presymptomatic axonal degeneration in the spinal cord of ALS mice. Brain Research, 1679, 45-52. https://doi.org/10.1016/j.brainres.2017.11.017
Gatto RG, Li W, Magin RL. Diffusion Tensor Imaging Identifies Presymptomatic Axonal Degeneration in the Spinal Cord of ALS Mice. Brain Res. 2018 01 15;1679:45-52. PubMed PMID: 29175489.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diffusion tensor imaging identifies presymptomatic axonal degeneration in the spinal cord of ALS mice. AU - Gatto,Rodolfo G, AU - Li,Weiguo, AU - Magin,Richard L, Y1 - 2017/11/23/ PY - 2017/08/18/received PY - 2017/11/14/revised PY - 2017/11/18/accepted PY - 2017/11/28/pubmed PY - 2018/8/10/medline PY - 2017/11/28/entrez KW - Amyotrophic lateral sclerosis KW - Axonal connectivity KW - Axonal degeneration KW - Diffusion tensor imaging KW - G93A-SOD1 mice SP - 45 EP - 52 JF - Brain research JO - Brain Res. VL - 1679 N2 - Extensive pathological evidence indicates that axonal degeneration represents an early and critical event in amyotrophic lateral sclerosis (ALS). Unfortunately, few MRI studies have focused in the early detection of white matter (WM) alterations in the spinal cord region. To unveil these WM changes, we performed high resolution diffusion tensor imaging (DTI) and correlated the results with histological analysis of adjacent slices taken from the spinal cords of presymptomatic mice. The DTI studies demonstrated a significant reduction in fractional anisotropy (FA) as well as axial diffusivities (AD) and an increase in radial diffusivity (RD), predominantly at lower segments of the spinal cord. Increases in FA and a reduction in AD and RD were observed in spinal cord (SC) gray matter (GM). Diffusion changes are associated with early and progressive alterations in axonal connectivity following a distal to proximal progression. Histological data tagging neuronal, axonal and glial cell markers demonstrated presymptomatic alterations in spinal cord WM and GM. This study demonstrates that DTI methods are optimal preclinical imaging tools to detect structural anomalies in WM and GM spinal cord during early stages of the disease. SN - 1872-6240 UR - https://www.unboundmedicine.com/medline/citation/29175489/Diffusion_tensor_imaging_identifies_presymptomatic_axonal_degeneration_in_the_spinal_cord_of_ALS_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(17)30512-7 DB - PRIME DP - Unbound Medicine ER -