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Role of ALAD and VDR genotypes on the association of low blood lead level with serum uric acid and blood pressure in automobile paint workers of Karachi, Pakistan.
Pak J Pharm Sci. 2017 Nov; 30(6):2223-2231.PJ

Abstract

Lead is an environmental pollutant having nephrotoxic effects even at low level. Its continuous exposure is associated with increased serum uric acid level that resulting in renal insufficiency. This research was conducted to see the effects of delta-aminolevulinic acid dehydratase (ALAD) and vitamin D receptor (VDR) genotypes on biochemical parameters and blood pressure (BP) of automobile workers having low blood lead level (BLL) with continuous lead exposure. Automobile paints workers with ALAD 1-2 genotype showed the positive association of BLL with diastolic BP (p<0.05) whereas, a genotypic combination of ALAD 1-2/VDR BB showed the negative association of serum uric acid with BLL (p<0.05). Similarly negative effects of VDR BB genotype (p<0.01) and ALAD 1-2 genotype (p<0.05) were observed in the association of serum uric acid with BLL at the mean age ≥30 years. This suggests that automobile paint workers having ALAD 1-2 genotypes are at the risk of increased diastolic BP. The research also foretells that combination of ALAD 1-2/VDR BB may play a significant role against lead induced nephrotoxicity at low BLL with continuous lead exposure.

Authors+Show Affiliations

Sadaf S
Department of Genetics, University of Karachi, Karachi, Pakistan.
Siddiqui AA
Faculty of Pharmacy & Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.
Ansari MA
Department of Genetics, University of Karachi, Karachi, Pakistan.

MeSH

AdultAutomobilesBiomarkersBlood PressureCase-Control StudiesCross-Sectional StudiesGene FrequencyGenotypeHumansLeadMaleOccupational ExposureOccupational HealthPaintPakistanPhenotypePorphobilinogen SynthaseReceptors, CalcitriolRisk AssessmentUric Acid

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29175793

Citation

Sadaf, Sadia, et al. "Role of ALAD and VDR Genotypes On the Association of Low Blood Lead Level With Serum Uric Acid and Blood Pressure in Automobile Paint Workers of Karachi, Pakistan." Pakistan Journal of Pharmaceutical Sciences, vol. 30, no. 6, 2017, pp. 2223-2231.
Sadaf S, Siddiqui AA, Ansari MA. Role of ALAD and VDR genotypes on the association of low blood lead level with serum uric acid and blood pressure in automobile paint workers of Karachi, Pakistan. Pak J Pharm Sci. 2017;30(6):2223-2231.
Sadaf, S., Siddiqui, A. A., & Ansari, M. A. (2017). Role of ALAD and VDR genotypes on the association of low blood lead level with serum uric acid and blood pressure in automobile paint workers of Karachi, Pakistan. Pakistan Journal of Pharmaceutical Sciences, 30(6), 2223-2231.
Sadaf S, Siddiqui AA, Ansari MA. Role of ALAD and VDR Genotypes On the Association of Low Blood Lead Level With Serum Uric Acid and Blood Pressure in Automobile Paint Workers of Karachi, Pakistan. Pak J Pharm Sci. 2017;30(6):2223-2231. PubMed PMID: 29175793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of ALAD and VDR genotypes on the association of low blood lead level with serum uric acid and blood pressure in automobile paint workers of Karachi, Pakistan. AU - Sadaf,Sadia, AU - Siddiqui,Afaq Ahmed, AU - Ansari,Maqsood Ali, PY - 2017/11/28/entrez PY - 2017/11/28/pubmed PY - 2019/7/30/medline SP - 2223 EP - 2231 JF - Pakistan journal of pharmaceutical sciences JO - Pak J Pharm Sci VL - 30 IS - 6 N2 - Lead is an environmental pollutant having nephrotoxic effects even at low level. Its continuous exposure is associated with increased serum uric acid level that resulting in renal insufficiency. This research was conducted to see the effects of delta-aminolevulinic acid dehydratase (ALAD) and vitamin D receptor (VDR) genotypes on biochemical parameters and blood pressure (BP) of automobile workers having low blood lead level (BLL) with continuous lead exposure. Automobile paints workers with ALAD 1-2 genotype showed the positive association of BLL with diastolic BP (p<0.05) whereas, a genotypic combination of ALAD 1-2/VDR BB showed the negative association of serum uric acid with BLL (p<0.05). Similarly negative effects of VDR BB genotype (p<0.01) and ALAD 1-2 genotype (p<0.05) were observed in the association of serum uric acid with BLL at the mean age ≥30 years. This suggests that automobile paint workers having ALAD 1-2 genotypes are at the risk of increased diastolic BP. The research also foretells that combination of ALAD 1-2/VDR BB may play a significant role against lead induced nephrotoxicity at low BLL with continuous lead exposure. SN - 1011-601X UR - https://www.unboundmedicine.com/medline/citation/29175793/Role_of_ALAD_and_VDR_genotypes_on_the_association_of_low_blood_lead_level_with_serum_uric_acid_and_blood_pressure_in_automobile_paint_workers_of_Karachi_Pakistan_ DB - PRIME DP - Unbound Medicine ER -