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Modulation of dual-task control with right prefrontal transcranial direct current stimulation (tDCS).
Exp Brain Res. 2018 01; 236(1):227-241.EB

Abstract

Executive functioning of two simultaneous component tasks in dual-task situations is primarily associated with activation of the lateral prefrontal cortex (PFC), as demonstrated in functional imaging studies. However, the precise role of the lateral PFC and the causal relation between this area's activity and executive functioning in dual tasks has exclusively been demonstrated for the left lateral PFC so far. To investigate this relation for the right lateral PFC, we used anodal transcranial direct current stimulation (atDCS; 1 mA, 20 min) in contrast to sham stimulation (1 mA, 30 s) in Experiment 1 (N = 30) as well as cathodal transcranial direct current stimulation (ctDCS; 1 mA, 20 min) in contrast to sham stimulation (1 mA, 30 s) in Experiment 2 (N = 25) over the right inferior frontal junction under conditions of random task order in dual tasks; random dual tasks require decisions on task order and thus high demands on executive functioning. Across these experiments, our results showed different tDCS-related effects: while atDCS improved performance evident from reduced error rates (Experiment 1), ctDCS impaired dual-task performance and increased these rates (Experiment 2). Moreover, baseline performance correlated with tDCS-induced performance changes, indicating that baseline performance was associated with atDCS-induced improvement. Our findings suggest that dual-task performance is causally related to right lateral PFC activation under conditions that require executive functioning as well as cognitive control of task sets and task order.

Authors+Show Affiliations

Department of Psychology, MSH Medical School Hamburg, Am Kaiserkai 1, 20457, Hamburg, Germany. tilo.strobach@medicalschool-hamburg.de.Department of Neurology, NeuroCure Cluster of Excellence, and Center for Stroke Research Berlin, Charite Universitätsmedizin Berlin, Berlin, Germany.Department of Neurology, NeuroCure Cluster of Excellence, and Center for Stroke Research Berlin, Charite Universitätsmedizin Berlin, Berlin, Germany.Department of Psychology, MSH Medical School Hamburg, Am Kaiserkai 1, 20457, Hamburg, Germany.Department of Neurology, NeuroCure Cluster of Excellence, and Center for Stroke Research Berlin, Charite Universitätsmedizin Berlin, Berlin, Germany. Department of Neurology, University of Greifswald, Greifswald, Germany.Department of Psychology, Martin Luther University Halle-Wittenberg, Halle, Germany.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29177817

Citation

Strobach, Tilo, et al. "Modulation of Dual-task Control With Right Prefrontal Transcranial Direct Current Stimulation (tDCS)." Experimental Brain Research, vol. 236, no. 1, 2018, pp. 227-241.
Strobach T, Antonenko D, Abbarin M, et al. Modulation of dual-task control with right prefrontal transcranial direct current stimulation (tDCS). Exp Brain Res. 2018;236(1):227-241.
Strobach, T., Antonenko, D., Abbarin, M., Escher, M., Flöel, A., & Schubert, T. (2018). Modulation of dual-task control with right prefrontal transcranial direct current stimulation (tDCS). Experimental Brain Research, 236(1), 227-241. https://doi.org/10.1007/s00221-017-5121-2
Strobach T, et al. Modulation of Dual-task Control With Right Prefrontal Transcranial Direct Current Stimulation (tDCS). Exp Brain Res. 2018;236(1):227-241. PubMed PMID: 29177817.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulation of dual-task control with right prefrontal transcranial direct current stimulation (tDCS). AU - Strobach,Tilo, AU - Antonenko,Daria, AU - Abbarin,Maral, AU - Escher,Malvin, AU - Flöel,Agnes, AU - Schubert,Torsten, Y1 - 2017/11/25/ PY - 2017/06/13/received PY - 2017/11/04/accepted PY - 2017/11/28/pubmed PY - 2018/12/12/medline PY - 2017/11/28/entrez KW - Brain stimulation KW - Dual tasks KW - Executive functions KW - Hemispheres KW - Task control SP - 227 EP - 241 JF - Experimental brain research JO - Exp Brain Res VL - 236 IS - 1 N2 - Executive functioning of two simultaneous component tasks in dual-task situations is primarily associated with activation of the lateral prefrontal cortex (PFC), as demonstrated in functional imaging studies. However, the precise role of the lateral PFC and the causal relation between this area's activity and executive functioning in dual tasks has exclusively been demonstrated for the left lateral PFC so far. To investigate this relation for the right lateral PFC, we used anodal transcranial direct current stimulation (atDCS; 1 mA, 20 min) in contrast to sham stimulation (1 mA, 30 s) in Experiment 1 (N = 30) as well as cathodal transcranial direct current stimulation (ctDCS; 1 mA, 20 min) in contrast to sham stimulation (1 mA, 30 s) in Experiment 2 (N = 25) over the right inferior frontal junction under conditions of random task order in dual tasks; random dual tasks require decisions on task order and thus high demands on executive functioning. Across these experiments, our results showed different tDCS-related effects: while atDCS improved performance evident from reduced error rates (Experiment 1), ctDCS impaired dual-task performance and increased these rates (Experiment 2). Moreover, baseline performance correlated with tDCS-induced performance changes, indicating that baseline performance was associated with atDCS-induced improvement. Our findings suggest that dual-task performance is causally related to right lateral PFC activation under conditions that require executive functioning as well as cognitive control of task sets and task order. SN - 1432-1106 UR - https://www.unboundmedicine.com/medline/citation/29177817/Modulation_of_dual_task_control_with_right_prefrontal_transcranial_direct_current_stimulation__tDCS__ L2 - https://dx.doi.org/10.1007/s00221-017-5121-2 DB - PRIME DP - Unbound Medicine ER -