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Neuroprotective Effect of σ1-Receptors on the Cell Model of Huntington's Disease.
Bull Exp Biol Med. 2017 Dec; 164(2):252-258.BE

Abstract

Huntington's disease is a hereditary neurodegenerative disease that primarily affects striatal neurons. Recent studies demonstrated abnormalities in calcium regulation in striatal neurons in Huntington's disease, which leads to elimination of synaptic connections between cortical and striatal neurons. In the present study, we focused on the neuroprotective properties of σ1-receptor, because one of its main functions is associated with modulation of calcium homeostasis in cells. The application of selective σ1-receptor agonists to the corticostriatal cell culture restores synaptic connections between the cortical and striatal neurons. Based on the obtained data, we assume that σ1-receptor is a promising target for the development of drugs for the therapy of Huntington's disease.

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Authors+Show Affiliations

Bol'shakova AV
Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg State Polytechnic University, St. Petersburg, Russia.
Kraskovskaya NA
Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg State Polytechnic University, St. Petersburg, Russia. ninakraskovskaya@gmail.com.
Gainullina AN
Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg State Polytechnic University, St. Petersburg, Russia.
Kukanova EO
Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg State Polytechnic University, St. Petersburg, Russia.
Vlasova OL
Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg State Polytechnic University, St. Petersburg, Russia.
Bezprozvanny IB
Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg State Polytechnic University, St. Petersburg, Russia. mnlabspb@gmail.com. Department of Physiology, UT Southwestern Medical Center at Dallas, Dallas, USA. mnlabspb@gmail.com.

MeSH

AnimalsAnisolesCalciumCerebral CortexCorpus StriatumDendritic SpinesGene ExpressionHomeostasisHuntington DiseaseMaleMiceModels, BiologicalMorpholinesNeuronsPiperidinesPrimary Cell CulturePropylaminesRNA, Small InterferingReceptors, sigmaSynapsesSynaptic TransmissionTransduction, Genetic

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29177899

Citation

Bol'shakova, A V., et al. "Neuroprotective Effect of σ1-Receptors On the Cell Model of Huntington's Disease." Bulletin of Experimental Biology and Medicine, vol. 164, no. 2, 2017, pp. 252-258.
Bol'shakova AV, Kraskovskaya NA, Gainullina AN, et al. Neuroprotective Effect of σ1-Receptors on the Cell Model of Huntington's Disease. Bull Exp Biol Med. 2017;164(2):252-258.
Bol'shakova, A. V., Kraskovskaya, N. A., Gainullina, A. N., Kukanova, E. O., Vlasova, O. L., & Bezprozvanny, I. B. (2017). Neuroprotective Effect of σ1-Receptors on the Cell Model of Huntington's Disease. Bulletin of Experimental Biology and Medicine, 164(2), 252-258. https://doi.org/10.1007/s10517-017-3968-7
Bol'shakova AV, et al. Neuroprotective Effect of σ1-Receptors On the Cell Model of Huntington's Disease. Bull Exp Biol Med. 2017;164(2):252-258. PubMed PMID: 29177899.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective Effect of σ1-Receptors on the Cell Model of Huntington's Disease. AU - Bol'shakova,A V, AU - Kraskovskaya,N A, AU - Gainullina,A N, AU - Kukanova,E O, AU - Vlasova,O L, AU - Bezprozvanny,I B, Y1 - 2017/11/25/ PY - 2017/5/4/received PY - 2017/11/28/pubmed PY - 2018/7/17/medline PY - 2017/11/28/entrez KW - Huntington’s disease KW - cortico-striatal cell cultures KW - dendritic spines KW - medium spiny neurons KW - σ1-receptor SP - 252 EP - 258 JF - Bulletin of experimental biology and medicine JO - Bull Exp Biol Med VL - 164 IS - 2 N2 - Huntington's disease is a hereditary neurodegenerative disease that primarily affects striatal neurons. Recent studies demonstrated abnormalities in calcium regulation in striatal neurons in Huntington's disease, which leads to elimination of synaptic connections between cortical and striatal neurons. In the present study, we focused on the neuroprotective properties of σ1-receptor, because one of its main functions is associated with modulation of calcium homeostasis in cells. The application of selective σ1-receptor agonists to the corticostriatal cell culture restores synaptic connections between the cortical and striatal neurons. Based on the obtained data, we assume that σ1-receptor is a promising target for the development of drugs for the therapy of Huntington's disease. SN - 1573-8221 UR - https://www.unboundmedicine.com/medline/citation/29177899/Neuroprotective_Effect_of_σ1_Receptors_on_the_Cell_Model_of_Huntington's_Disease_ DB - PRIME DP - Unbound Medicine ER -