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Clinical effect of a manual toothbrush with tapered filaments on dental plaque and gingivitis reduction.
Am J Dent. 2017 Oct; 30(5):272-278.AJ

Abstract

PURPOSE

To evaluate the anti-plaque efficacy (Study 1) and the anti-gingivitis efficacy (Study 2) of a manual toothbrush with tapered bristles compared to marketed control manual toothbrushes.

METHODS

Studies 1 and 2 were independent, randomized and controlled, single-center, examiner-blind clinical trials in generally healthy adults. Study 1 included a 2-day acclimation period, followed by a 5-day twice daily toothbrushing test phase with the assigned brush. Baseline and Day 5 pre- and post-brushing plaque levels were assessed via Turesky Modified Quigley-Hein Plaque Index (TMQHPI). In Study 2, subjects with existing gingivitis brushed with their assigned toothbrush twice daily for 4 weeks. Gingivitis was measured using the Mazza Modification of the Papillary Bleeding Index at Baseline and Weeks 2 and 4. In both trials, subjects were randomly assigned to either the manual toothbrush with tapered bristles (Oral-B Super Thin Indicator toothbrush, OM159) or the marketed control (Study 1: Oral-B Complete Clean & Sensitive toothbrush; Study 2: Crest Pro-Health Complete 7 Brush 35 toothbrush) for use with a regular fluoridated dentifrice.

RESULTS

40 (Study 1) and 63 (Study 2) subjects were randomized in each trial. In Study 1, both the tapered bristle and marketed control brushes provided significant (P< 0.0001) mean whole mouth plaque reductions at Day 1 and Day 5 post-brushing relative to pre-brushing as measured via TMQPHI, with no between-brush significant differences. Both groups showed a significant reduction in Day 5 post-brushing mean plaque scores versus Day 1 pre- brushing mean plaque scores (P< 0.0001), but the reductions were not significantly different between groups (P= 0.4274). In Study 2, both the tapered bristle brush and the marketed control brush produced significant (P< 0.0001) reductions in both gingivitis and number of gingival bleeding sites at both Weeks 2 and 4 versus baseline. At Week 4, the tapered filament toothbrush group showed 8.6% less gingivitis (P= 0.0017) and 33.4% fewer bleeding sites (P= 0.0030) versus the control brush. All toothbrushes were well-tolerated.

CLINICAL SIGNIFICANCE

Twice daily customary use of a manual toothbrush with tapered bristles provided clinically meaningful plaque and gingivitis reduction benefits.

Authors+Show Affiliations

Department of Operative Dentistry & Endodontics School of Stomatology, Fourth Military Medical University, Xi'an, China.Department of Operative Dentistry& Endodontics School of Stomatology, Fourth Military Medical University, Xi'an, China.The Procter & Gamble Company, Mason, Ohio, USA.The Procter & Gamble Company, Beijing Technical Center, Beijing, China.The Procter & Gamble Company, Beijing Technical Center, Beijing, China.The Procter & Gamble Company, Beijing Technical Center, Beijing, China.Procter & Gamble Service GmbH German Innovation Center, Kronberg, Germany.The Procter & Gamble Company, Mason, Ohio, USA.The Procter & Gamble Company, Mason, Ohio, USA.

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

29178731

Citation

Ni, Longxing, et al. "Clinical Effect of a Manual Toothbrush With Tapered Filaments On Dental Plaque and Gingivitis Reduction." American Journal of Dentistry, vol. 30, no. 5, 2017, pp. 272-278.
Ni L, Tang R, He T, et al. Clinical effect of a manual toothbrush with tapered filaments on dental plaque and gingivitis reduction. Am J Dent. 2017;30(5):272-278.
Ni, L., Tang, R., He, T., Chang, J., Li, J., Li, S., Ccahuana-Vasquez, R. A., Cheng, R., & Grender, J. (2017). Clinical effect of a manual toothbrush with tapered filaments on dental plaque and gingivitis reduction. American Journal of Dentistry, 30(5), 272-278.
Ni L, et al. Clinical Effect of a Manual Toothbrush With Tapered Filaments On Dental Plaque and Gingivitis Reduction. Am J Dent. 2017;30(5):272-278. PubMed PMID: 29178731.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical effect of a manual toothbrush with tapered filaments on dental plaque and gingivitis reduction. AU - Ni,Longxing, AU - Tang,Rongying, AU - He,Tao, AU - Chang,Jinlan, AU - Li,Jiahui, AU - Li,Sarah, AU - Ccahuana-Vasquez,Renzo Alberto, AU - Cheng,Richard, AU - Grender,Julie, PY - 2017/11/28/entrez PY - 2017/11/28/pubmed PY - 2018/7/14/medline SP - 272 EP - 278 JF - American journal of dentistry JO - Am J Dent VL - 30 IS - 5 N2 - PURPOSE: To evaluate the anti-plaque efficacy (Study 1) and the anti-gingivitis efficacy (Study 2) of a manual toothbrush with tapered bristles compared to marketed control manual toothbrushes. METHODS: Studies 1 and 2 were independent, randomized and controlled, single-center, examiner-blind clinical trials in generally healthy adults. Study 1 included a 2-day acclimation period, followed by a 5-day twice daily toothbrushing test phase with the assigned brush. Baseline and Day 5 pre- and post-brushing plaque levels were assessed via Turesky Modified Quigley-Hein Plaque Index (TMQHPI). In Study 2, subjects with existing gingivitis brushed with their assigned toothbrush twice daily for 4 weeks. Gingivitis was measured using the Mazza Modification of the Papillary Bleeding Index at Baseline and Weeks 2 and 4. In both trials, subjects were randomly assigned to either the manual toothbrush with tapered bristles (Oral-B Super Thin Indicator toothbrush, OM159) or the marketed control (Study 1: Oral-B Complete Clean & Sensitive toothbrush; Study 2: Crest Pro-Health Complete 7 Brush 35 toothbrush) for use with a regular fluoridated dentifrice. RESULTS: 40 (Study 1) and 63 (Study 2) subjects were randomized in each trial. In Study 1, both the tapered bristle and marketed control brushes provided significant (P< 0.0001) mean whole mouth plaque reductions at Day 1 and Day 5 post-brushing relative to pre-brushing as measured via TMQPHI, with no between-brush significant differences. Both groups showed a significant reduction in Day 5 post-brushing mean plaque scores versus Day 1 pre- brushing mean plaque scores (P< 0.0001), but the reductions were not significantly different between groups (P= 0.4274). In Study 2, both the tapered bristle brush and the marketed control brush produced significant (P< 0.0001) reductions in both gingivitis and number of gingival bleeding sites at both Weeks 2 and 4 versus baseline. At Week 4, the tapered filament toothbrush group showed 8.6% less gingivitis (P= 0.0017) and 33.4% fewer bleeding sites (P= 0.0030) versus the control brush. All toothbrushes were well-tolerated. CLINICAL SIGNIFICANCE: Twice daily customary use of a manual toothbrush with tapered bristles provided clinically meaningful plaque and gingivitis reduction benefits. SN - 0894-8275 UR - https://www.unboundmedicine.com/medline/citation/29178731/Clinical_effect_of_a_manual_toothbrush_with_tapered_filaments_on_dental_plaque_and_gingivitis_reduction_ DB - PRIME DP - Unbound Medicine ER -