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Association between apolipoprotein E gene polymorphism and mild cognitive impairment: a meta-analysis.
Clin Interv Aging 2017; 12:1941-1949CI

Abstract

A number of published case-control studies reported that the apolipoprotein E (ApoE) gene polymorphism was associated with the mild cognitive impairment (MCI). However, previous reports still remain conflicting. To estimate the association between ApoE polymorphism and MCI susceptibility, we searched the electronic databases including PubMed, Wanfang, CNKI (China National Knowledge Infrastructure), VIP, and EMBASE to retrieve all available studies. A total of 18 studies with 2,004 cases and 3,705 controls were included in this meta-analysis. The pooled analysis based on selected studies showed that statistically significant risk association was found between ApoE gene polymorphism and MCI in overall population (ε4 vs ε3: odds ratio [OR] =2.38, 95% confidence interval [CI]: 2.11-2.68; ε4/ε4 vs ε3/ε3: OR =4.45, 95% CI: 3.06-6.48; ε2/ε4 vs ε3/ε3: OR =2.57, 95% CI: 1.77-3.73; ε3/ε4 vs ε3/ε3: OR =2.31, 95% CI: 1.99-2.69). However, no significant association was detected in two genetic models: ε2 versus ε3 (OR =0.90, 95% CI: 0.77-1.05) and ε2/ε2 versus ε3/ε3 (OR =0.91, 95% CI: 0.50-1.65). Furthermore, ApoE ε2/ε3 genotype provided a slight protection for MCI in overall population (ε2/ε3 vs ε3/ε3: OR =0.80, 95% CI: 0.66-0.97). In the stratified analysis based on ethnicity, similar results were also observed in Chinese population (significant risk: ε4 vs ε3: OR =2.52, 95% CI: 2.19-2.90; ε4/ε4 vs ε3/ε3: OR =5.45, 95% CI: 3.41-8.70; ε2/ε4 vs ε3/ε3: OR =2.59, 95% CI: 1.74-3.86; ε3/ε4 vs ε3/ε3: OR =2.34, 95% CI: 1.97-2.79; slight protection: ε2/ε3 vs ε3/ε3: OR =0.79, 95% CI: 0.64-0.98; no association: ε2 vs ε3: OR =0.92, 95% CI: 0.78-1.09; and ε2/ε2 vs ε3/ε3: OR =1.04, 95% CI: 0.55-1.99). In summary, this meta-analysis of 5,709 subjects suggested that ApoE ε4 allele was associated with an increased risk of MCI. In addition, ApoE ε2/ε3 genotype provided a slight protection for MCI.

Authors+Show Affiliations

Nursing College of Qingdao University, Qingdao University.Department of Neurosurgery, Affiliated Hospital of Qingdao University, Qingdao, China.Department of Neurosurgery, Affiliated Hospital of Qingdao University, Qingdao, China.Department of Neurosurgery, Affiliated Hospital of Qingdao University, Qingdao, China.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

29180857

Citation

Jiang, Yunxia, et al. "Association Between Apolipoprotein E Gene Polymorphism and Mild Cognitive Impairment: a Meta-analysis." Clinical Interventions in Aging, vol. 12, 2017, pp. 1941-1949.
Jiang Y, He T, Deng W, et al. Association between apolipoprotein E gene polymorphism and mild cognitive impairment: a meta-analysis. Clin Interv Aging. 2017;12:1941-1949.
Jiang, Y., He, T., Deng, W., & Sun, P. (2017). Association between apolipoprotein E gene polymorphism and mild cognitive impairment: a meta-analysis. Clinical Interventions in Aging, 12, pp. 1941-1949. doi:10.2147/CIA.S143632.
Jiang Y, et al. Association Between Apolipoprotein E Gene Polymorphism and Mild Cognitive Impairment: a Meta-analysis. Clin Interv Aging. 2017;12:1941-1949. PubMed PMID: 29180857.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between apolipoprotein E gene polymorphism and mild cognitive impairment: a meta-analysis. AU - Jiang,Yunxia, AU - He,Tao, AU - Deng,Wenshuai, AU - Sun,Peng, Y1 - 2017/11/13/ PY - 2017/11/29/entrez PY - 2017/11/29/pubmed PY - 2018/6/5/medline KW - apolipoprotein E KW - meta-analysis KW - mild cognitive impairment KW - polymorphism SP - 1941 EP - 1949 JF - Clinical interventions in aging JO - Clin Interv Aging VL - 12 N2 - A number of published case-control studies reported that the apolipoprotein E (ApoE) gene polymorphism was associated with the mild cognitive impairment (MCI). However, previous reports still remain conflicting. To estimate the association between ApoE polymorphism and MCI susceptibility, we searched the electronic databases including PubMed, Wanfang, CNKI (China National Knowledge Infrastructure), VIP, and EMBASE to retrieve all available studies. A total of 18 studies with 2,004 cases and 3,705 controls were included in this meta-analysis. The pooled analysis based on selected studies showed that statistically significant risk association was found between ApoE gene polymorphism and MCI in overall population (ε4 vs ε3: odds ratio [OR] =2.38, 95% confidence interval [CI]: 2.11-2.68; ε4/ε4 vs ε3/ε3: OR =4.45, 95% CI: 3.06-6.48; ε2/ε4 vs ε3/ε3: OR =2.57, 95% CI: 1.77-3.73; ε3/ε4 vs ε3/ε3: OR =2.31, 95% CI: 1.99-2.69). However, no significant association was detected in two genetic models: ε2 versus ε3 (OR =0.90, 95% CI: 0.77-1.05) and ε2/ε2 versus ε3/ε3 (OR =0.91, 95% CI: 0.50-1.65). Furthermore, ApoE ε2/ε3 genotype provided a slight protection for MCI in overall population (ε2/ε3 vs ε3/ε3: OR =0.80, 95% CI: 0.66-0.97). In the stratified analysis based on ethnicity, similar results were also observed in Chinese population (significant risk: ε4 vs ε3: OR =2.52, 95% CI: 2.19-2.90; ε4/ε4 vs ε3/ε3: OR =5.45, 95% CI: 3.41-8.70; ε2/ε4 vs ε3/ε3: OR =2.59, 95% CI: 1.74-3.86; ε3/ε4 vs ε3/ε3: OR =2.34, 95% CI: 1.97-2.79; slight protection: ε2/ε3 vs ε3/ε3: OR =0.79, 95% CI: 0.64-0.98; no association: ε2 vs ε3: OR =0.92, 95% CI: 0.78-1.09; and ε2/ε2 vs ε3/ε3: OR =1.04, 95% CI: 0.55-1.99). In summary, this meta-analysis of 5,709 subjects suggested that ApoE ε4 allele was associated with an increased risk of MCI. In addition, ApoE ε2/ε3 genotype provided a slight protection for MCI. SN - 1178-1998 UR - https://www.unboundmedicine.com/medline/citation/29180857/Association_between_apolipoprotein_E_gene_polymorphism_and_mild_cognitive_impairment:_a_meta_analysis_ L2 - https://dx.doi.org/10.2147/CIA.S143632 DB - PRIME DP - Unbound Medicine ER -