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High incidence of extra-genital gonorrheal and chlamydial infections among high-risk men who have sex with men and transgender women in Peru.
Int J STD AIDS. 2018 05; 29(6):568-576.IJ

Abstract

Extra-genital Neisseria gonorrhoeae and Chlamydia trachomatis infections are associated with antimicrobial resistance and HIV acquisition. We analyzed data from a cohort of men who have sex with men (MSM) and transgender women followed quarterly for two years in Peru. Incident cases were defined as positive N. gonorrhoeae or C. trachomatis nucleic acid tests during follow-up. Repeat positive tests were defined as reinfection among those with documented treatment. We used generalized estimating equations to calculate adjusted incidence rate ratios (aIRRs). Of 404 participants, 22% were transgender. Incidence rates of rectal N. gonorrhoeae and C. trachomatis infection were 28.1 and 37.3 cases per 100 person-years, respectively. Incidence rates of pharyngeal N. gonorrhoeae and C. trachomatis infection were 21.3 and 9.6 cases per 100 person-years, respectively. Incident HIV infection was associated with incident rectal (aIRR = 2.43; 95% CI 1.66-3.55) N. gonorrhoeae infection. Identifying as transgender versus cisgender MSM was associated with incident pharyngeal N. gonorrhoeae (aIRR = 1.85; 95% CI 1.12-3.07) infection. The incidence of extra-genital N. gonorrhoeae and C. trachomatis infections was high in our population. The association with incident HIV infection warrants evaluating the impact of rectal N. gonorrhoeae screening and treatment on HIV transmission.

Authors+Show Affiliations

1 Division of Infectious Diseases: Department of Medicine, 12222 David Geffen School of Medicine, University of California Los Angeles, USA.1 Division of Infectious Diseases: Department of Medicine, 12222 David Geffen School of Medicine, University of California Los Angeles, USA. 2 Center for Interdisciplinary Studies in Sexuality, AIDS and Society, Universidad Peruana Cayetano Heredia, Lima, Peru.2 Center for Interdisciplinary Studies in Sexuality, AIDS and Society, Universidad Peruana Cayetano Heredia, Lima, Peru. 3 Laboratory of Sexual Health, Universidad Peruana Cayetano Heredia, Lima, Peru.2 Center for Interdisciplinary Studies in Sexuality, AIDS and Society, Universidad Peruana Cayetano Heredia, Lima, Peru. 3 Laboratory of Sexual Health, Universidad Peruana Cayetano Heredia, Lima, Peru.3 Laboratory of Sexual Health, Universidad Peruana Cayetano Heredia, Lima, Peru.1 Division of Infectious Diseases: Department of Medicine, 12222 David Geffen School of Medicine, University of California Los Angeles, USA.2 Center for Interdisciplinary Studies in Sexuality, AIDS and Society, Universidad Peruana Cayetano Heredia, Lima, Peru.1 Division of Infectious Diseases: Department of Medicine, 12222 David Geffen School of Medicine, University of California Los Angeles, USA. 4 Department of Epidemiology, Fielding School of Public Health, 12222 University of California Los Angeles , USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

29183269

Citation

Allan-Blitz, Lao-Tzu, et al. "High Incidence of Extra-genital Gonorrheal and Chlamydial Infections Among High-risk Men Who Have Sex With Men and Transgender Women in Peru." International Journal of STD & AIDS, vol. 29, no. 6, 2018, pp. 568-576.
Allan-Blitz LT, Konda KA, Calvo GM, et al. High incidence of extra-genital gonorrheal and chlamydial infections among high-risk men who have sex with men and transgender women in Peru. Int J STD AIDS. 2018;29(6):568-576.
Allan-Blitz, L. T., Konda, K. A., Calvo, G. M., Vargas, S. K., Leon, S. R., Segura, E. R., Caceres, C. F., & Klausner, J. D. (2018). High incidence of extra-genital gonorrheal and chlamydial infections among high-risk men who have sex with men and transgender women in Peru. International Journal of STD & AIDS, 29(6), 568-576. https://doi.org/10.1177/0956462417744098
Allan-Blitz LT, et al. High Incidence of Extra-genital Gonorrheal and Chlamydial Infections Among High-risk Men Who Have Sex With Men and Transgender Women in Peru. Int J STD AIDS. 2018;29(6):568-576. PubMed PMID: 29183269.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High incidence of extra-genital gonorrheal and chlamydial infections among high-risk men who have sex with men and transgender women in Peru. AU - Allan-Blitz,Lao-Tzu, AU - Konda,Kelika A, AU - Calvo,Gino M, AU - Vargas,Silver K, AU - Leon,Segundo R, AU - Segura,Eddy R, AU - Caceres,Carlos F, AU - Klausner,Jeffrey D, Y1 - 2017/11/29/ PY - 2017/12/1/pubmed PY - 2019/1/19/medline PY - 2017/11/30/entrez KW - Neisseria gonorrhoeae, Chlamydia trachomatis KW - South America KW - men who have sex with men, transgender women SP - 568 EP - 576 JF - International journal of STD & AIDS JO - Int J STD AIDS VL - 29 IS - 6 N2 - Extra-genital Neisseria gonorrhoeae and Chlamydia trachomatis infections are associated with antimicrobial resistance and HIV acquisition. We analyzed data from a cohort of men who have sex with men (MSM) and transgender women followed quarterly for two years in Peru. Incident cases were defined as positive N. gonorrhoeae or C. trachomatis nucleic acid tests during follow-up. Repeat positive tests were defined as reinfection among those with documented treatment. We used generalized estimating equations to calculate adjusted incidence rate ratios (aIRRs). Of 404 participants, 22% were transgender. Incidence rates of rectal N. gonorrhoeae and C. trachomatis infection were 28.1 and 37.3 cases per 100 person-years, respectively. Incidence rates of pharyngeal N. gonorrhoeae and C. trachomatis infection were 21.3 and 9.6 cases per 100 person-years, respectively. Incident HIV infection was associated with incident rectal (aIRR = 2.43; 95% CI 1.66-3.55) N. gonorrhoeae infection. Identifying as transgender versus cisgender MSM was associated with incident pharyngeal N. gonorrhoeae (aIRR = 1.85; 95% CI 1.12-3.07) infection. The incidence of extra-genital N. gonorrhoeae and C. trachomatis infections was high in our population. The association with incident HIV infection warrants evaluating the impact of rectal N. gonorrhoeae screening and treatment on HIV transmission. SN - 1758-1052 UR - https://www.unboundmedicine.com/medline/citation/29183269/High_incidence_of_extra_genital_gonorrheal_and_chlamydial_infections_among_high_risk_men_who_have_sex_with_men_and_transgender_women_in_Peru_ L2 - https://journals.sagepub.com/doi/10.1177/0956462417744098?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -