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Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome.
Nutrients. 2017 11 24; 9(12)N

Abstract

This study was carried out to evaluate the effects of vitamin D supplementation on the metabolic profiles of insulin-resistant subjects with polycystic ovary syndrome (PCOS). This randomized double-blind, placebo-controlled trial was conducted on 90 insulin-resistant women with PCOS. Participants were randomly assigned to three groups to intake either 4000 IU of vitamin D or 1000 IU of vitamin D or placebo (n = 30 each group) daily for 12 weeks. Vitamin D supplementation (4000 IU), compared with vitamin D (1000 IU) and placebo, led to significant reductions in total testosterone (-0.2 ± 0.2 vs. -0.1 ± 0.6 and +0.1 ± 0.2 ng/mL, respectively, p = 0.02), free androgen index (FAI) (-0.06 ± 0.12 vs. -0.02 ± 0.12 and +0.004 ± 0.04, respectively, p = 0.04), hirsutism (-1.1 ± 1.1 vs. -0.8 ± 1.2 and -0.1 ± 0.4, respectively, p = 0.001) and high-sensitivity C-reactive protein (hs-CRP) (-0.7 ± 1.4 vs. -0.5 ± 0.9 and +0.5 ± 2.4 mg/L, respectively, p = 0.01). In addition, we found significant elevations in mean change of sex hormone-binding globulin (SHBG) (+19.1 ± 23.0 vs. +4.5 ± 11.0 and +0.7 ± 10.4 nmol/L, respectively, p < 0.001) and total antioxidant capacity (TAC) (+130 ± 144 vs. +33 ± 126 and -36 ± 104 mmol/L, respectively, p < 0.001) in the high-dose vitamin D group compared with low-dose vitamin D and placebo groups. Overall, high-dose vitamin D administration for 12 weeks to insulin-resistant women with PCOS had beneficial effects on total testosterone, SHBG, FAI, serum hs-CRP and plasma TAC levels compared with low-dose vitamin D and placebo groups.

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Authors+Show Affiliations

Jamilian M
Endocrinology and Metabolism Research Center, Arak University of Medical Sciences, Arak 6618634683, Iran
Foroozanfard F
Department of Gynecology and Obstetrics, School of Medicine, Kashan University of Medical Sciences, Kashan 8715988141, Iran
Rahmani E
Department of Gynecology and Obstetrics, School of Medicine, Bushehr University of Medical Sciences, Bushehr 7514633341, Iran
Talebi M
Department of Gynecology and Obstetrics, School of Medicine, Kashan University of Medical Sciences, Kashan 8715988141, Iran
Bahmani F
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan 8715988141, Iran
Asemi Z
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan 8715988141, Iran

MeSH

AdolescentAdultAndrogensAnthropometryBiomarkersBlood GlucoseC-Reactive ProteinDietDietary CarbohydratesDietary FatsDietary FiberDietary ProteinsDietary SupplementsDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansInsulin ResistanceMetabolomeNutrition AssessmentOxidative StressPolycystic Ovary SyndromeSex Hormone-Binding GlobulinTestosteroneVitamin DYoung Adult

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

29186759

Citation

Jamilian, Mehri, et al. "Effect of Two Different Doses of Vitamin D Supplementation On Metabolic Profiles of Insulin-Resistant Patients With Polycystic Ovary Syndrome." Nutrients, vol. 9, no. 12, 2017.
Jamilian M, Foroozanfard F, Rahmani E, et al. Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome. Nutrients. 2017;9(12).
Jamilian, M., Foroozanfard, F., Rahmani, E., Talebi, M., Bahmani, F., & Asemi, Z. (2017). Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome. Nutrients, 9(12). https://doi.org/10.3390/nu9121280
Jamilian M, et al. Effect of Two Different Doses of Vitamin D Supplementation On Metabolic Profiles of Insulin-Resistant Patients With Polycystic Ovary Syndrome. Nutrients. 2017 11 24;9(12) PubMed PMID: 29186759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome. AU - Jamilian,Mehri, AU - Foroozanfard,Fatemeh, AU - Rahmani,Elham, AU - Talebi,Maesoomeh, AU - Bahmani,Fereshteh, AU - Asemi,Zatollah, Y1 - 2017/11/24/ PY - 2017/10/13/received PY - 2017/11/06/revised PY - 2017/11/07/accepted PY - 2017/12/1/entrez PY - 2017/12/1/pubmed PY - 2018/8/2/medline KW - hormonal profiles KW - insulin-resistant KW - polycystic ovary syndrome KW - vitamin D supplementation JF - Nutrients JO - Nutrients VL - 9 IS - 12 N2 - This study was carried out to evaluate the effects of vitamin D supplementation on the metabolic profiles of insulin-resistant subjects with polycystic ovary syndrome (PCOS). This randomized double-blind, placebo-controlled trial was conducted on 90 insulin-resistant women with PCOS. Participants were randomly assigned to three groups to intake either 4000 IU of vitamin D or 1000 IU of vitamin D or placebo (n = 30 each group) daily for 12 weeks. Vitamin D supplementation (4000 IU), compared with vitamin D (1000 IU) and placebo, led to significant reductions in total testosterone (-0.2 ± 0.2 vs. -0.1 ± 0.6 and +0.1 ± 0.2 ng/mL, respectively, p = 0.02), free androgen index (FAI) (-0.06 ± 0.12 vs. -0.02 ± 0.12 and +0.004 ± 0.04, respectively, p = 0.04), hirsutism (-1.1 ± 1.1 vs. -0.8 ± 1.2 and -0.1 ± 0.4, respectively, p = 0.001) and high-sensitivity C-reactive protein (hs-CRP) (-0.7 ± 1.4 vs. -0.5 ± 0.9 and +0.5 ± 2.4 mg/L, respectively, p = 0.01). In addition, we found significant elevations in mean change of sex hormone-binding globulin (SHBG) (+19.1 ± 23.0 vs. +4.5 ± 11.0 and +0.7 ± 10.4 nmol/L, respectively, p < 0.001) and total antioxidant capacity (TAC) (+130 ± 144 vs. +33 ± 126 and -36 ± 104 mmol/L, respectively, p < 0.001) in the high-dose vitamin D group compared with low-dose vitamin D and placebo groups. Overall, high-dose vitamin D administration for 12 weeks to insulin-resistant women with PCOS had beneficial effects on total testosterone, SHBG, FAI, serum hs-CRP and plasma TAC levels compared with low-dose vitamin D and placebo groups. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/29186759/Effect_of_Two_Different_Doses_of_Vitamin_D_Supplementation_on_Metabolic_Profiles_of_Insulin_Resistant_Patients_with_Polycystic_Ovary_Syndrome_ DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓25 ↑40]

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