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Profile of red blood cell morphologies and causes of anaemia among pregnant women at first clinic visit in the mount Cameroon area: a prospective cross sectional study.
BMC Res Notes. 2017 Nov 29; 10(1):645.BR

Abstract

OBJECTIVE

Anaemia is a serious problem in pregnancy in malaria-endemic countries. This study investigated red cell morphologies and possible causes of anaemia among pregnant women at first clinic visit. Venous blood samples from consented women were used to determine haemoglobin (Hb) levels, mean corpuscular volume (MCV) and mean corpuscular haemoglobin (MCH) using an automated haematology analyzer. Malaria parasitaemia was diagnosed by microscopy. Definitions were as follows: anaemia (Hb < 11.0 g/dl), microcytosis (MCV < 78 fl), macrocytosis (MCV > 101 fl), hypochromasia (MCH < 27 pg), microcytic hypochromia or normocytic hypochromia with anaemia [iron deficiency anaemia (IDA)], normocytic normochromia with anaemia in the absence of malaria parasitaemia (physiological anaemia of pregnancy).

RESULTS

Of the 279 pregnant women enrolled, 57% had anaemia. Malaria parasitaemia was associated with 23.3% of anaemic cases while 76.7% were non-malaria related. The distribution of red cell alterations was as follows: hypochromasia (32.6%), microcytosis (14.7%) and macrocytosis (1.1%). The co-occurrence of malaria parasitaemia, iron deficiency and anaemia was seen in 23.3% of the women, iron deficiency anaemia only occurred in 35.9% while physiological anaemia of pregnancy was 40.9%. Iron deficiency and physiological anaemia of pregnancy contribute to a greater proportion of anaemia in the study area.

Authors+Show Affiliations

Department of Zoology and Animal Physiology, University of Buea, 63, Buea, Cameroon. kuoh2000@yahoo.fr.Department of Zoology and Animal Physiology, University of Buea, 63, Buea, Cameroon.Department of Biological Sciences, University of Bamenda, 39, Bamenda, Cameroon.Department of Biochemistry and Molecular Biology, University of Buea, 63, Buea, Cameroon.Department of Molecular Parasitology, University of Buea, 63, Buea, Cameroon.Department of Molecular Parasitology, University of Buea, 63, Buea, Cameroon.Department of Biochemistry and Molecular Biology, University of Buea, 63, Buea, Cameroon.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29187241

Citation

Anchang-Kimbi, Judith K., et al. "Profile of Red Blood Cell Morphologies and Causes of Anaemia Among Pregnant Women at First Clinic Visit in the Mount Cameroon Area: a Prospective Cross Sectional Study." BMC Research Notes, vol. 10, no. 1, 2017, p. 645.
Anchang-Kimbi JK, Nkweti VN, Ntonifor HN, et al. Profile of red blood cell morphologies and causes of anaemia among pregnant women at first clinic visit in the mount Cameroon area: a prospective cross sectional study. BMC Res Notes. 2017;10(1):645.
Anchang-Kimbi, J. K., Nkweti, V. N., Ntonifor, H. N., Apinjoh, T. O., Chi, H. F., Tata, R. B., & Achidi, E. A. (2017). Profile of red blood cell morphologies and causes of anaemia among pregnant women at first clinic visit in the mount Cameroon area: a prospective cross sectional study. BMC Research Notes, 10(1), 645. https://doi.org/10.1186/s13104-017-2961-6
Anchang-Kimbi JK, et al. Profile of Red Blood Cell Morphologies and Causes of Anaemia Among Pregnant Women at First Clinic Visit in the Mount Cameroon Area: a Prospective Cross Sectional Study. BMC Res Notes. 2017 Nov 29;10(1):645. PubMed PMID: 29187241.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Profile of red blood cell morphologies and causes of anaemia among pregnant women at first clinic visit in the mount Cameroon area: a prospective cross sectional study. AU - Anchang-Kimbi,Judith K, AU - Nkweti,Vera Ngenwie, AU - Ntonifor,Helen Ngum, AU - Apinjoh,Tobias O, AU - Chi,Hanesh Fru, AU - Tata,Rolland Bantar, AU - Achidi,Eric Akum, Y1 - 2017/11/29/ PY - 2016/06/23/received PY - 2017/11/21/accepted PY - 2017/12/1/entrez PY - 2017/12/1/pubmed PY - 2018/7/22/medline KW - Anaemia and pregnancy KW - Red blood cell indices SP - 645 EP - 645 JF - BMC research notes JO - BMC Res Notes VL - 10 IS - 1 N2 - OBJECTIVE: Anaemia is a serious problem in pregnancy in malaria-endemic countries. This study investigated red cell morphologies and possible causes of anaemia among pregnant women at first clinic visit. Venous blood samples from consented women were used to determine haemoglobin (Hb) levels, mean corpuscular volume (MCV) and mean corpuscular haemoglobin (MCH) using an automated haematology analyzer. Malaria parasitaemia was diagnosed by microscopy. Definitions were as follows: anaemia (Hb < 11.0 g/dl), microcytosis (MCV < 78 fl), macrocytosis (MCV > 101 fl), hypochromasia (MCH < 27 pg), microcytic hypochromia or normocytic hypochromia with anaemia [iron deficiency anaemia (IDA)], normocytic normochromia with anaemia in the absence of malaria parasitaemia (physiological anaemia of pregnancy). RESULTS: Of the 279 pregnant women enrolled, 57% had anaemia. Malaria parasitaemia was associated with 23.3% of anaemic cases while 76.7% were non-malaria related. The distribution of red cell alterations was as follows: hypochromasia (32.6%), microcytosis (14.7%) and macrocytosis (1.1%). The co-occurrence of malaria parasitaemia, iron deficiency and anaemia was seen in 23.3% of the women, iron deficiency anaemia only occurred in 35.9% while physiological anaemia of pregnancy was 40.9%. Iron deficiency and physiological anaemia of pregnancy contribute to a greater proportion of anaemia in the study area. SN - 1756-0500 UR - https://www.unboundmedicine.com/medline/citation/29187241/Profile_of_red_blood_cell_morphologies_and_causes_of_anaemia_among_pregnant_women_at_first_clinic_visit_in_the_mount_Cameroon_area:_a_prospective_cross_sectional_study_ L2 - https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-017-2961-6 DB - PRIME DP - Unbound Medicine ER -