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[Pregnancy complications among women with polycystic ovary syndrome in China: a Meta-analysis].
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2017; 42(11):1300-1310ZN

Abstract

OBJECTIVE

To estimate the status of pregnancy complications among women with polycystic ovary syndrome (PCOS) through a systematic review of published literatures. Methods: Systematic literature searches were conducted in PubMed, Web of Science, Medline, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang, Weipu and China Biology Medicine disc (CBMdisc), as well as the relevant articles published from inception to April 1st 2017, which reported the prevalence of pregnancy complications among women with PCOS. Random effective models were used to calculate pooled prevalence and 95% confidence intervals. The Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of those included studies. Subgroup analyses were used to evaluate the influence of overweight/obesity and insulin resistance before pregnancy on the estimates of pregnancy complications among women with PCOS. Results: Fifty-nine studies involving 13 378 PCOS women and 49 395 non-PCOS women were included. Among women with PCOS, pooled estimates were 20.26% for gestational diabetes mellitus, 13.94% for hypertensive disorder of pregnancy, 64.16% for caesarean section, 13.35% for preterm birth, 9.84% for macrosomia, 5.88% for low birth weight, 5.25% for early gestational age, 8.45% for late gestational age, 1.93% for neonatal malformations, 0.88% for perinatal mortality and 3.71% for neonatal asphyxia. And the estimates of gestational diabetes mellitus, hypertensive disorder of pregnancy, caesarean section, preterm birth, macrosomia and neonatal asphyxia among women with PCOS were significantly higher than those in women without PCOS (all P<0.05). Subgroup analysis showed the estimates of gestational diabetes mellitus, macrosomia and late gestational age among PCOS women who were overweight/obesity before pregnancy were significant higher than those among PCOS women with normal BMI (all P<0.05); and compared to PCOS women without insulin resistance prior to pregnancy, PCOS women with pre-pregnancy insulin resistance were at an increased risk for gestational diabetes mellitus, preterm birth and macrosomia (all P<0.05). Conclusion: PCOS in pregnancy is associated with high rates of pregnancy complications. It is an important risk factor for pregnancy complications.

Authors+Show Affiliations

Department of Epidemiology and Health Statistics, School of Xiangya Public Health, Central South University, Changsha 410078, China.Department of Epidemiology and Health Statistics, School of Xiangya Public Health, Central South University, Changsha 410078, China.Department of Epidemiology and Health Statistics, School of Xiangya Public Health, Central South University, Changsha 410078, China.Information Institute, Deyang Center for Disease Control and Prevention, Deyang Sichuan 618000, China.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

chi

PubMed ID

29187658

Citation

Wang, Tingting, et al. "[Pregnancy Complications Among Women With Polycystic Ovary Syndrome in China: a Meta-analysis]." Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences, vol. 42, no. 11, 2017, pp. 1300-1310.
Wang T, Fu H, Chen L, et al. [Pregnancy complications among women with polycystic ovary syndrome in China: a Meta-analysis]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2017;42(11):1300-1310.
Wang, T., Fu, H., Chen, L., & Xu, Y. (2017). [Pregnancy complications among women with polycystic ovary syndrome in China: a Meta-analysis]. Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences, 42(11), pp. 1300-1310. doi:10.11817/j.issn.1672-7347.2017.11.010.
Wang T, et al. [Pregnancy Complications Among Women With Polycystic Ovary Syndrome in China: a Meta-analysis]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2017 Nov 28;42(11):1300-1310. PubMed PMID: 29187658.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Pregnancy complications among women with polycystic ovary syndrome in China: a Meta-analysis]. AU - Wang,Tingting, AU - Fu,Hanlin, AU - Chen,Lizhang, AU - Xu,Yang, PY - 2017/12/1/entrez PY - 2017/12/1/pubmed PY - 2018/10/23/medline SP - 1300 EP - 1310 JF - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences JO - Zhong Nan Da Xue Xue Bao Yi Xue Ban VL - 42 IS - 11 N2 - OBJECTIVE: To estimate the status of pregnancy complications among women with polycystic ovary syndrome (PCOS) through a systematic review of published literatures. Methods: Systematic literature searches were conducted in PubMed, Web of Science, Medline, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang, Weipu and China Biology Medicine disc (CBMdisc), as well as the relevant articles published from inception to April 1st 2017, which reported the prevalence of pregnancy complications among women with PCOS. Random effective models were used to calculate pooled prevalence and 95% confidence intervals. The Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of those included studies. Subgroup analyses were used to evaluate the influence of overweight/obesity and insulin resistance before pregnancy on the estimates of pregnancy complications among women with PCOS. Results: Fifty-nine studies involving 13 378 PCOS women and 49 395 non-PCOS women were included. Among women with PCOS, pooled estimates were 20.26% for gestational diabetes mellitus, 13.94% for hypertensive disorder of pregnancy, 64.16% for caesarean section, 13.35% for preterm birth, 9.84% for macrosomia, 5.88% for low birth weight, 5.25% for early gestational age, 8.45% for late gestational age, 1.93% for neonatal malformations, 0.88% for perinatal mortality and 3.71% for neonatal asphyxia. And the estimates of gestational diabetes mellitus, hypertensive disorder of pregnancy, caesarean section, preterm birth, macrosomia and neonatal asphyxia among women with PCOS were significantly higher than those in women without PCOS (all P<0.05). Subgroup analysis showed the estimates of gestational diabetes mellitus, macrosomia and late gestational age among PCOS women who were overweight/obesity before pregnancy were significant higher than those among PCOS women with normal BMI (all P<0.05); and compared to PCOS women without insulin resistance prior to pregnancy, PCOS women with pre-pregnancy insulin resistance were at an increased risk for gestational diabetes mellitus, preterm birth and macrosomia (all P<0.05). Conclusion: PCOS in pregnancy is associated with high rates of pregnancy complications. It is an important risk factor for pregnancy complications. SN - 1672-7347 UR - https://www.unboundmedicine.com/medline/citation/29187658/[Pregnancy_complications_among_women_with_polycystic_ovary_syndrome_in_China:_a_Meta_analysis]_ L2 - http://xbyxb.csu.edu.cn/xbwk/fileup/PDF/2017111300.pdf DB - PRIME DP - Unbound Medicine ER -