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Killing two birds with one stone: The multifunctional roles of mesenchymal stem cells in the treatment of neurodegenerative and muscle diseases.

Abstract

Neurodegenerative and muscle diseases bear both complex and multifactorial pathologies. An efficacious and robust therapeutic option to treat these diseases is yet to be elucidated. At such a time, mesenchymal stem cells have drawn significant attention due to their immunomodulatory and regenerative properties. Accumulating evidence has proposed the capability of MSCs to serve multiple roles in a broad spectrum of diseases by secretion of trophic or paracrine factors. In the present review, we will look into the recent literature and discuss the therapeutic functions of MSCs and their potential to treat various neurodegenerative (Alzheimer's, Parkinson's, and Huntington's disease) and muscle (Duchenne muscular dystrophy, myopathy, and multiple sclerosis) diseases.

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  • Authors+Show Affiliations

    ,

    Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea. Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Neuroscience Center, Samsung Medical Center, Seoul, Republic of Korea. Stem Cell and Regenerative Medicine Institute, Samsung Medical Center, Seoul, Republic of Korea.

    ,

    Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea. Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Neuroscience Center, Samsung Medical Center, Seoul, Republic of Korea. Stem Cell and Regenerative Medicine Institute, Samsung Medical Center, Seoul, Republic of Korea.

    Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea. Stem Cell and Regenerative Medicine Institute, Samsung Medical Center, Seoul, Republic of Korea. jongwook.chang@samsung.com.

    Source

    Histology and histopathology : 2017 Nov 30 pg 11951

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    29188600