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Killing two birds with one stone: The multifunctional roles of mesenchymal stem cells in the treatment of neurodegenerative and muscle diseases.

Abstract

Neurodegenerative and muscle diseases bear both complex and multifactorial pathologies. An efficacious and robust therapeutic option to treat these diseases is yet to be elucidated. At such a time, mesenchymal stem cells have drawn significant attention due to their immunomodulatory and regenerative properties. Accumulating evidence has proposed the capability of MSCs to serve multiple roles in a broad spectrum of diseases by secretion of trophic or paracrine factors. In the present review, we will look into the recent literature and discuss the therapeutic functions of MSCs and their potential to treat various neurodegenerative (Alzheimer's, Parkinson's, and Huntington's disease) and muscle (Duchenne muscular dystrophy, myopathy, and multiple sclerosis) diseases.

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  • Authors+Show Affiliations

    ,

    Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea. Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Neuroscience Center, Samsung Medical Center, Seoul, Republic of Korea. Stem Cell and Regenerative Medicine Institute, Samsung Medical Center, Seoul, Republic of Korea.

    ,

    Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea. Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Neuroscience Center, Samsung Medical Center, Seoul, Republic of Korea. Stem Cell and Regenerative Medicine Institute, Samsung Medical Center, Seoul, Republic of Korea.

    Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea. Stem Cell and Regenerative Medicine Institute, Samsung Medical Center, Seoul, Republic of Korea. jongwook.chang@samsung.com.

    Source

    Histology and histopathology 33:7 2018 Jul pg 629-638

    MeSH

    Animals
    Humans
    Mesenchymal Stem Cell Transplantation
    Mesenchymal Stromal Cells
    Muscular Diseases
    Neurodegenerative Diseases

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    29188600

    Citation

    TY - JOUR T1 - Killing two birds with one stone: The multifunctional roles of mesenchymal stem cells in the treatment of neurodegenerative and muscle diseases. AU - Lee,Na Kyung, AU - Na,Duk L, AU - Chang,Jong Wook, Y1 - 2017/11/30/ PY - 2017/12/1/pubmed PY - 2018/10/20/medline PY - 2017/12/1/entrez SP - 629 EP - 638 JF - Histology and histopathology JO - Histol. Histopathol. VL - 33 IS - 7 N2 - Neurodegenerative and muscle diseases bear both complex and multifactorial pathologies. An efficacious and robust therapeutic option to treat these diseases is yet to be elucidated. At such a time, mesenchymal stem cells have drawn significant attention due to their immunomodulatory and regenerative properties. Accumulating evidence has proposed the capability of MSCs to serve multiple roles in a broad spectrum of diseases by secretion of trophic or paracrine factors. In the present review, we will look into the recent literature and discuss the therapeutic functions of MSCs and their potential to treat various neurodegenerative (Alzheimer's, Parkinson's, and Huntington's disease) and muscle (Duchenne muscular dystrophy, myopathy, and multiple sclerosis) diseases. SN - 1699-5848 UR - https://www.unboundmedicine.com/medline/citation/29188600/Killing_two_birds_with_one_stone:_The_multifunctional_roles_of_mesenchymal_stem_cells_in_the_treatment_of_neurodegenerative_and_muscle_diseases. L2 - http://www.hh.um.es/Abstracts/Vol_33/33_7/33_7_629.htm ER -